Resolution of hypertension following adrenalectomy in patients with pheochromocytoma and Conn's syndrome: A comparative cohort study.
4 affiliations
- 1Department of Urology, Pain Medicine and Critical Care, All India Institute of Medical Sciences, New Delhi, India.
- 2Department of Pathology, Pain Medicine and Critical Care, All India Institute of Medical Sciences, New Delhi, India.
- 3Department of Anaesthesiology, Pain Medicine and Critical Care, All India Institute of Medical Sciences, New Delhi, India.
- 4Department of Endocrinology, Metabolism and Diabetes, All India Institute of Medical Sciences, New Delhi, India.
Abstract
Introduction
There is limited literature comparing the resolution of hypertension after adrenalectomy for pheochromocytoma and Conn's syndrome endocrine hypertension. We assessed the rate of hypertension remission and factors predicting it among patients undergoing adrenalectomy.Methods
As part of an institutional review board-approved study, we retrieved data of patients who underwent adrenalectomy for localized pheochromocytoma or Conn's syndrome between 2020 and 2024 at our institution. Patients were contacted telephonically to assess the status of their hypertension.Results
Out of 61 eligible patients, 31 with pheochromocytoma and 16 with Conn's syndrome were included in this study. Patients with pheochromocytoma were younger (mean age: 30.8 years vs. 42.8 years), had a lower body mass index (20.7 kg/m² vs. 28.4 kg/m²), had a lower preoperative duration of hypertension (median- 12 vs. 84 months), and had fewer antihypertensive medicines (median 2 vs. 4) than patients with Conn's syndrome. At discharge, 82.6% (n = 19/23) of pheochromocytoma patients achieved complete hypertension remission vs. 31.2% (n = 5/16) of Conn's syndrome patients (P < 0.01). At 1 year after surgery, remission was maintained in 85% (17/20) and 50% (7/14) of patients, respectively (P = 0.05). Older age (odds ratio [OR]: 1.08), worse preoperative disease burden (OR: 2.23), multifocal lesions on histopathology (OR: 12.27), and chronic kidney disease (OR: 15.43) were associated with persistence of hypertension postoperatively.Conclusions
Adrenalectomy achieves quicker and more complete resolution of hypertension in patients with pheochromocytoma than in Conn's syndrome. Persistent hypertension is more likely in older patients with long standing, severe baseline hypertension, and other comorbidities.
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BibTeX
@article{gupta2026resolution,
title = {{Resolution of hypertension following adrenalectomy in patients with pheochromocytoma and Conn's syndrome: A comparative cohort study.}},
author = {Mehul Gupta and Shipra Agarwal and Rashmi Ramachandran and Nikhil Tandon and Nitya Tripathi and Rajeev Kumar},
journal = {Indian journal of urology : IJU : journal of the Urological Society of India},
year = {2026},
month = sep,
doi = {10.4103/iju.iju_338_26},
url = {https://europepmc.org/article/MED/42910102},
note = {CC BY-NC-SA},
}
RIS
TY - JOUR
TI - Resolution of hypertension following adrenalectomy in patients with pheochromocytoma and Conn's syndrome: A comparative cohort study.
AU - Mehul Gupta
AU - Shipra Agarwal
AU - Rashmi Ramachandran
AU - Nikhil Tandon
AU - Nitya Tripathi
AU - Rajeev Kumar
PY - 2026
DA - 2026/09/29
JO - Indian journal of urology : IJU : journal of the Urological Society of India
DO - 10.4103/iju.iju_338_26
UR - https://europepmc.org/article/MED/42910102
AB - Introduction There is limited literature comparing the resolution of hypertension after adrenalectomy for pheochromocytoma and Conn's syndrome endocrine hypertension. We assessed the rate of hypertension remission and factors predicting it among patients undergoing adrenalectomy.Methods As part of an institutional review board-approved study, we retrieved data of patients who underwent adrenalectomy for localized pheochromocytoma or Conn's syndrome between 2020 and 2024 at our institution. Patients were contacted telephonically to assess the status of their hypertension.Results Out of 61 eligible patients, 31 with pheochromocytoma and 16 with Conn's syndrome were included in this study. Patients with pheochromocytoma were younger (mean age: 30.8 years vs. 42.8 years), had a lower body mass index (20.7 kg/m² vs. 28.4 kg/m²), had a lower preoperative duration of hypertension (median- 12 vs. 84 months), and had fewer antihypertensive medicines (median 2 vs. 4) than patients with Conn's syndrome. At discharge, 82.6% (n = 19/23) of pheochromocytoma patients achieved complete hypertension remission vs. 31.2% (n = 5/16) of Conn's syndrome patients (P < 0.01). At 1 year after surgery, remission was maintained in 85% (17/20) and 50% (7/14) of patients, respectively (P = 0.05). Older age (odds ratio [OR]: 1.08), worse preoperative disease burden (OR: 2.23), multifocal lesions on histopathology (OR: 12.27), and chronic kidney disease (OR: 15.43) were associated with persistence of hypertension postoperatively.Conclusions Adrenalectomy achieves quicker and more complete resolution of hypertension in patients with pheochromocytoma than in Conn's syndrome. Persistent hypertension is more likely in older patients with long standing, severe baseline hypertension, and other comorbidities.
SN - 0970-1591
SN - 1998-3824
ER -