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Peer-reviewedCC BY 4.0Journal of Neural Transmission

Dysphagia and gastrointestinal disorders in Parkinson’s disease: towards a diagnostic standard operating procedure for the interprofessional neurological outpatient care team

  • Inga Claus1
  • Carsten Buhmann2
  • Alessandra Fanciulli3
  • Stephan Klebe4
  • Franz Marxreiter5
  • Patrick Süß6
  • David Weise7,8
  • Tobias Warnecke9
9 affiliations
  1. 1Department of Neurology, University Hospital of Muenster, Albert-Schweitzer- Campus 1, 48149 Muenster, Germany
  2. 2Department of Neurology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246 Hamburg, Germany
  3. 3Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria
  4. 4Department of Neurology, Knappschaft Hospital Recklinghausen, Recklinghausen, Germany
  5. 5Center for Movement Disorders, Passauer Wolf, Bad Gögging, Neustadt an der Donau, Germany
  6. 6Department of Molecular Neurology, University Hospital Erlangen, Friedrich- Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany
  7. 7Department of Neurology and Pain Therapy, Asklepios Fachklinikum Stadtroda, Stadroda, Germany
  8. 8Department of Neurology, University of Leipzig, Leipzig, Germany
  9. 9Department of Neurology and Neurorehabilitation, Klinikum Osnabrueck, Osnabrueck, Germany
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Abstract

Gastrointestinal Disorders in people with Parkinson’s disease (PwP) are able to cause widespread clinical symptoms which can be challenging to classify in day-to-day clinical practice. In the upper gastrointestinal tract (GIT) oropharyngeal dysphagia, esophageal motility disorders as well as delayed gastric emptying may cause nutrition problems and reduce the efficacy of oral pharmacotherapy. In the lower GIT, bacterial overgrowth and prolonged colorectal transit times induce different stages of constipation leading to reduced quality of life and GIT comorbidities as well. Most of these symptoms reflect alpha-synuclein pathology in both the enteric nervous system and at various sites of the peripheral and central nervous systems. Besides, the growing use of various device aided therapies may additionally raise specific clinical questions about the interference with the GIT motility. This standard operating procedure (SOP) is intended to provide specific recommendations for diagnostic steps as well as therapeutic options, especially for interprofessional neurological outpatient care teams.

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Cite

BibTeXRIS
BibTeX
@article{claus2026dysphagia,
  title = {{Dysphagia and gastrointestinal disorders in Parkinson’s disease: towards a diagnostic standard operating procedure for the interprofessional neurological outpatient care team}},
  author = {Inga Claus and Carsten Buhmann and Alessandra Fanciulli and Stephan Klebe and Franz Marxreiter and Patrick Süß and David Weise and Tobias Warnecke},
  journal = {Journal of Neural Transmission},
  year = {2026},
  month = aug,
  doi = {10.1007/s00702-026-03195-z},
  url = {https://doi.org/10.1007/s00702-026-03195-z},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Dysphagia and gastrointestinal disorders in Parkinson’s disease: towards a diagnostic standard operating procedure for the interprofessional neurological outpatient care team
AU  - Inga Claus
AU  - Carsten Buhmann
AU  - Alessandra Fanciulli
AU  - Stephan Klebe
AU  - Franz Marxreiter
AU  - Patrick Süß
AU  - David Weise
AU  - Tobias Warnecke
PY  - 2026
DA  - 2026/08/21
JO  - Journal of Neural Transmission
DO  - 10.1007/s00702-026-03195-z
UR  - https://doi.org/10.1007/s00702-026-03195-z
AB  - Gastrointestinal Disorders in people with Parkinson’s disease (PwP) are able to cause widespread clinical symptoms which can be challenging to classify in day-to-day clinical practice. In the upper gastrointestinal tract (GIT) oropharyngeal dysphagia, esophageal motility disorders as well as delayed gastric emptying may cause nutrition problems and reduce the efficacy of oral pharmacotherapy. In the lower GIT, bacterial overgrowth and prolonged colorectal transit times induce different stages of constipation leading to reduced quality of life and GIT comorbidities as well. Most of these symptoms reflect alpha-synuclein pathology in both the enteric nervous system and at various sites of the peripheral and central nervous systems. Besides, the growing use of various device aided therapies may additionally raise specific clinical questions about the interference with the GIT motility. This standard operating procedure (SOP) is intended to provide specific recommendations for diagnostic steps as well as therapeutic options, especially for interprofessional neurological outpatient care teams.
SN  - 0300-9564
SN  - 1435-1463
ER  -