An integrated One Health methodology to study Rift Valley fever, Crimean-Congo haemorrhagic fever and brucellosis at the human-livestock-wildlife interface in Uganda☆

@article{kizito2026integrated,
  title = {{An integrated One Health methodology to study Rift Valley fever, Crimean-Congo haemorrhagic fever and brucellosis at the human-livestock-wildlife interface in Uganda☆}},
  author = {Dennison Kizito and Sam Tweed and Joseph Mutyaba and Nackson Babi and Swaib Abubaker Lule and Gladys Nakanjako Kiggundu and Rory Gibb and Charity Angella Nassuna and Ronald Ssali Ogwal and Ebenezer Paul and Mercy Haumba and Collins Agaba and Phiona Katushabe and Eric Morris Enyel and Stephen Balinandi and Lydia Franklinos and Naomi Fuller and Leah Owen and Elise Ringwaldt and Laura Ferguson and Deo Birungi Ndumu and Musa Sekamatte and Patrick Atimnedi and Luke Nyakarahuka and Gladys Kalema-Zikusoka and Ibrahim Abubakar and Nigel Field and Janet Seeley and Julius Julian Lutwama and COHRIE-Uganda Team},
  journal = {One health (Amsterdam, Netherlands)},
  year = {2026},
  month = sep,
  doi = {10.1016/j.onehlt.2026.101576},
  url = {https://europepmc.org/article/PMC/PMC13716995},
  note = {CC BY-NC-ND},
}

TY  - JOUR
TI  - An integrated One Health methodology to study Rift Valley fever, Crimean-Congo haemorrhagic fever and brucellosis at the human-livestock-wildlife interface in Uganda☆
AU  - Dennison Kizito
AU  - Sam Tweed
AU  - Joseph Mutyaba
AU  - Nackson Babi
AU  - Swaib Abubaker Lule
AU  - Gladys Nakanjako Kiggundu
AU  - Rory Gibb
AU  - Charity Angella Nassuna
AU  - Ronald Ssali Ogwal
AU  - Ebenezer Paul
AU  - Mercy Haumba
AU  - Collins Agaba
AU  - Phiona Katushabe
AU  - Eric Morris Enyel
AU  - Stephen Balinandi
AU  - Lydia Franklinos
AU  - Naomi Fuller
AU  - Leah Owen
AU  - Elise Ringwaldt
AU  - Laura Ferguson
AU  - Deo Birungi Ndumu
AU  - Musa Sekamatte
AU  - Patrick Atimnedi
AU  - Luke Nyakarahuka
AU  - Gladys Kalema-Zikusoka
AU  - Ibrahim Abubakar
AU  - Nigel Field
AU  - Janet Seeley
AU  - Julius Julian Lutwama
AU  - COHRIE-Uganda Team
PY  - 2026
DA  - 2026/09/25
JO  - One health (Amsterdam, Netherlands)
DO  - 10.1016/j.onehlt.2026.101576
UR  - https://europepmc.org/article/PMC/PMC13716995
AB  - Zoonotic diseases pose a significant public health challenge, with most emerging diseases originating from animal populations. In Uganda, Rift Valley fever (RVF), Crimean-Congo haemorrhagic fever (CCHF) and brucellosis are endemic, yet critical gaps remain in understanding their transmission dynamics, key vectors and reservoirs, environmental drivers, community knowledge and behaviours and the implementation of One Health policies. The Collaborative One Health Research Initiative on Epidemics-Uganda (COHRIE-Uganda) study developed an integrated, interdisciplinary approach to investigate these diseases across ecologically diverse areas characterised by intense human-livestock-wildlife interaction. The study methodology comprised sequential cross-sectional surveys combining quantitative and qualitative methods, involving community members, livestock, wildlife and vectors across six conservation areas in Uganda. Household surveys and blood sampling were obtained from 3018 individuals and 35 focus group discussions were conducted across 96 villages. 67 in-depth interviews with community leaders and 26 interviews with national policymakers were conducted to evaluate One Health policy implementation. Livestock practices were assessed through farmer questionnaires and blood sampling of 2199 cattle, 343 sheep, 78 pigs and 1582 goats. Invertebrate vector sampling was undertaken of 72,744 mosquitoes and 9273 ticks on livestock hosts with vertebrate host sampling of 612 small mammals. 233 large wildlife were sampled by blood and nasal swabs. Real-time monitoring and detection of zoonotic outbreaks was provided by 127 trained Community One Health Volunteers embedded at each site. COHRIE-Uganda presents a novel interdisciplinary methodology to study zoonotic disease, applying a One Health approach integrating molecular epidemiology, ecology, social sciences and community participatory methods involving humans, livestock, vectors, and wildlife to inform culturally sensitive zoonotic disease interventions.
SN  - 2352-7714
ER  -