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Peer-reviewedCC BY-NC-NDNpj metabolic health and disease

SWI/SNF chromatin remodeling complexes in metabolic disorders: integrating tissue-specific epigenetic mechanisms.

  • Faiz Ur Rahman1
  • Zong Wei2,3
  1. 1Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Scottsdale, AZ, USA.
  2. 2Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Scottsdale, AZ, USA. [email protected].
  3. 3Division of Endocrinology, Mayo Clinic Arizona, Scottsdale, AZ, USA. [email protected].
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Abstract

Metabolic disorders are increasingly linked to epigenetic alterations. SWI/SNF chromatin remodeling complexes have emerged as critical modulators of metabolic homeostasis. In this review, we focus on the tissue-specific biological function of SWI/SNF complexes in the pancreas, liver, adipose tissue, and heart, and highlight the dysregulation of chromatin remodeling in metabolic disease progression. Lastly, we discuss therapeutic opportunities targeting chromatin remodeling mechanisms in metabolic disorders.

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Cite

BibTeXRIS
BibTeX
@article{rahman2026swisnf,
  title = {{SWI/SNF chromatin remodeling complexes in metabolic disorders: integrating tissue-specific epigenetic mechanisms.}},
  author = {Faiz Ur Rahman and Zong Wei},
  journal = {Npj metabolic health and disease},
  year = {2026},
  month = nov,
  doi = {10.1038/s44324-026-00137-x},
  url = {https://europepmc.org/article/MED/42972009},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - SWI/SNF chromatin remodeling complexes in metabolic disorders: integrating tissue-specific epigenetic mechanisms.
AU  - Faiz Ur Rahman
AU  - Zong Wei
PY  - 2026
DA  - 2026/11/02
JO  - Npj metabolic health and disease
DO  - 10.1038/s44324-026-00137-x
UR  - https://europepmc.org/article/MED/42972009
AB  - Metabolic disorders are increasingly linked to epigenetic alterations. SWI/SNF chromatin remodeling complexes have emerged as critical modulators of metabolic homeostasis. In this review, we focus on the tissue-specific biological function of SWI/SNF complexes in the pancreas, liver, adipose tissue, and heart, and highlight the dysregulation of chromatin remodeling in metabolic disease progression. Lastly, we discuss therapeutic opportunities targeting chromatin remodeling mechanisms in metabolic disorders.
SN  - 2948-2828
ER  -