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Peer-reviewedCC BYFrontiers in genetics

Chromatin remodeling in bone organoids: from epigenetic regulation to disease modeling and therapeutic translation.

  • Yuxin Zheng1
  • Desheng Liu2
  • Jun Hou3
  • Hong Ding4,5
  • Yingying He6
6 affiliations
  1. 1School of Clinical Medicine, Qiqihar Medical University, Qiqihar, China.
  2. 2Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China.
  3. 3School of Clinical Medicine, Chengdu Medical College, The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, China.
  4. 4Orthopedic Center, Liangjiang Hospital Affiliated to Chongqing Medical University, Chongqing, China.
  5. 5Orthopedic Center, the People's Hospital of Chongqing Liangjiang New Area, Chongqing, China.
  6. 6Jiulongpo District Maternal and Child Healthcare Hospital, Chongqing, China.
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Abstract

Chromatin remodeling contributes to skeletal development, tissue homeostasis, and disease by regulating nucleosome positioning, chromatin accessibility, and histone modifications. Bone organoids can partially reproduce the three-dimensional human bone microenvironment and provide new in vitro models for studying skeletal pathophysiology. This review summarizes recent progress in chromatin remodeling and bone organoid research, with a focus on the roles of switch/sucrose non-fermenting (SWI/SNF), imitation switch (ISWI), and chromodomain helicase deoxyribonucleic acid (DNA)-binding (CHD) complexes in bone organoid regulation. We also discuss the relationships between bone organoids and enhancer remodeling, DNA methylation, histone modifications, chromatin organization, and cellular metabolism. In addition, we summarize the applications of emerging technologies, including multiomics, spatial epigenomics, and live cell imaging, in bone organoid studies. The current limitations of these models are also considered. Finally, we discuss potential directions for the further development and refinement of bone organoids. We highlight their potential applications in bone disease research, drug screening, and future clinical translation within the context of chromatin remodeling.

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Cite

BibTeXRIS
BibTeX
@article{zheng2026chromatin,
  title = {{Chromatin remodeling in bone organoids: from epigenetic regulation to disease modeling and therapeutic translation.}},
  author = {Yuxin Zheng and Desheng Liu and Jun Hou and Hong Ding and Yingying He},
  journal = {Frontiers in genetics},
  year = {2026},
  month = sep,
  doi = {10.3389/fgene.2026.1975296},
  url = {https://europepmc.org/article/MED/42909312},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Chromatin remodeling in bone organoids: from epigenetic regulation to disease modeling and therapeutic translation.
AU  - Yuxin Zheng
AU  - Desheng Liu
AU  - Jun Hou
AU  - Hong Ding
AU  - Yingying He
PY  - 2026
DA  - 2026/09/28
JO  - Frontiers in genetics
DO  - 10.3389/fgene.2026.1975296
UR  - https://europepmc.org/article/MED/42909312
AB  - Chromatin remodeling contributes to skeletal development, tissue homeostasis, and disease by regulating nucleosome positioning, chromatin accessibility, and histone modifications. Bone organoids can partially reproduce the three-dimensional human bone microenvironment and provide new in vitro models for studying skeletal pathophysiology. This review summarizes recent progress in chromatin remodeling and bone organoid research, with a focus on the roles of switch/sucrose non-fermenting (SWI/SNF), imitation switch (ISWI), and chromodomain helicase deoxyribonucleic acid (DNA)-binding (CHD) complexes in bone organoid regulation. We also discuss the relationships between bone organoids and enhancer remodeling, DNA methylation, histone modifications, chromatin organization, and cellular metabolism. In addition, we summarize the applications of emerging technologies, including multiomics, spatial epigenomics, and live cell imaging, in bone organoid studies. The current limitations of these models are also considered. Finally, we discuss potential directions for the further development and refinement of bone organoids. We highlight their potential applications in bone disease research, drug screening, and future clinical translation within the context of chromatin remodeling.
SN  - 1664-8021
ER  -