Peer-reviewedCC BY-NC-NDCirculation Journal
Sex Differences in Clinical Outcomes After Transcatheter Aortic Valve Implantation ― Insights From a Nationwide Japanese Registry ―
Abstract
BACKGROUND: Sex differences in outcomes after transcatheter aortic valve implantation (TAVI) for aortic stenosis in Japan have not been fully investigated. METHODS AND RESULTS: increase; 95% confidence interval [CI] 0.77-0.91; P<0.001). Female sex was independently associated with lower risks of in-hospital mortality (aOR 0.60; 95% CI 0.45-0.81) and major RCC transfusion (aOR 0.79; 95% CI 0.71-0.89), but a higher risk of PPI (aOR 1.15; 95% CI 1.02-1.30). CONCLUSIONS: In a Japanese TAVI registry, crude mortality was comparable between the sexes, but women had higher major RCC transfusion and PPI rates. After adjusting for BSA and available measured covariates, female sex was associated with lower in-hospital mortality. Combined sex and BSA assessment appears important for predicting post-TAVI outcomes.
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BibTeX
@article{mitsui2026differences,
title = {{Sex Differences in Clinical Outcomes After Transcatheter Aortic Valve Implantation ― Insights From a Nationwide Japanese Registry ―}},
author = {Kentaro Mitsui and Kensuke Takagi and Yu Kataoka and Yoko Sumita and Koshiro Kanaoka and Yoshihiro Miyamoto and Yuki Irie and Atsushi Okada and Hideaki Kanzaki and Satsuki Fukushima and Kota Murai and Kenichiro Sawada and Hideo Matama and Takamasa Iwai and Satoshi Honda and Masashi Fujino and Kazuhiro Nakao and Shuichi Yoneda and Yasuhide Asaumi and Kenichi Tsujita and Kazuhiro Yamamoto and Teruo Noguchi},
journal = {Circulation Journal},
year = {2026},
month = aug,
doi = {10.1253/circj.cj-26-0492},
url = {https://www.jstage.jst.go.jp/article/circj/advpub/0/advpub_CJ-26-0492/_article},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Sex Differences in Clinical Outcomes After Transcatheter Aortic Valve Implantation ― Insights From a Nationwide Japanese Registry ―
AU - Kentaro Mitsui
AU - Kensuke Takagi
AU - Yu Kataoka
AU - Yoko Sumita
AU - Koshiro Kanaoka
AU - Yoshihiro Miyamoto
AU - Yuki Irie
AU - Atsushi Okada
AU - Hideaki Kanzaki
AU - Satsuki Fukushima
AU - Kota Murai
AU - Kenichiro Sawada
AU - Hideo Matama
AU - Takamasa Iwai
AU - Satoshi Honda
AU - Masashi Fujino
AU - Kazuhiro Nakao
AU - Shuichi Yoneda
AU - Yasuhide Asaumi
AU - Kenichi Tsujita
AU - Kazuhiro Yamamoto
AU - Teruo Noguchi
PY - 2026
DA - 2026/08/27
JO - Circulation Journal
DO - 10.1253/circj.cj-26-0492
UR - https://www.jstage.jst.go.jp/article/circj/advpub/0/advpub_CJ-26-0492/_article
AB - BACKGROUND: Sex differences in outcomes after transcatheter aortic valve implantation (TAVI) for aortic stenosis in Japan have not been fully investigated. METHODS AND RESULTS: increase; 95% confidence interval [CI] 0.77-0.91; P<0.001). Female sex was independently associated with lower risks of in-hospital mortality (aOR 0.60; 95% CI 0.45-0.81) and major RCC transfusion (aOR 0.79; 95% CI 0.71-0.89), but a higher risk of PPI (aOR 1.15; 95% CI 1.02-1.30). CONCLUSIONS: In a Japanese TAVI registry, crude mortality was comparable between the sexes, but women had higher major RCC transfusion and PPI rates. After adjusting for BSA and available measured covariates, female sex was associated with lower in-hospital mortality. Combined sex and BSA assessment appears important for predicting post-TAVI outcomes.
SN - 1347-4820
SN - 1346-9843
ER -