Improvement in health-related quality of life after complex biventricular repair.
5 affiliations
- 1Department of Cardiology, Boston Children's Hospital, Boston, Mass.
- 2Department of Pediatrics, Harvard Medical School, Boston, Mass.
- 3Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Mass.
- 4Department of Cardiothoracic Surgery, Boston Children's Hospital, Boston, Mass.
- 5Department of Surgery, Harvard Medical School, Boston, Mass.
Abstract
Objective
Complex biventricular (BiV) and one-and-a-half ventricle (1.5V) repairs are alternatives to single ventricle palliation. We describe 1 domain of the health-related quality of life of patients undergoing BiV and 1.5V repairs.Methods
This single-center study included children (≤ 18 years) who underwent BiV or 1.5V repairs between October 1, 2022, and July 7, 2024. Parents completed Pediatric Quality of Life Inventory Infant Scales or Pediatric Quality of Life Inventory 3.0 Cardiac Modules; physical function and physical symptom scores for patients younger than 2 years and heart problems and treatment scores for patients 2 years and older were evaluated.Results
Seventy-three patients, 36 younger than 2 years and 37 ages 2 years and older, were included. Forty-one patients (56%) underwent BiV surgery, and 32 (44%) underwent 1.5V surgery. Preoperatively, patients younger than 2 years had a mean physical symptom score of 76 ± 14 and a mean physical function score of 70 ± 20; patients ages 2 years and older had a mean heart problems and treatment score of 64 ± 20. Thirty-six patients, 10 younger than 2 years and 26 ages 2 years and older, had paired pre- and postoperative health-related quality of life data. Following repair, physical symptom scores improved among infants ages 0 to 12 months (mean, 67 vs 79; P = .033), and heart problems and treatment scores improved (ages 2 to 4 years, 69 vs 84; P = .002; ages 5 to 7 years, 57 vs 86; P = .044). For patients ages 2 years and older, 5 symptoms drove score improvement: exertional dyspnea, chest pain, tachycardia, cyanosis, and fatigue.Conclusions
Six months after surgery, parents reported improvement in children's health-related quality of life following complex BiV or 1.5V repairs. Further work is needed to better understand long-term outcomes in this vulnerable population.
Related
- Greater and Clinically Meaningful Improvement in Health-Related Quality of Life After Device-Aided Therapy in Younger Patients Earlier Within Advanced Parkinson’s Disease: Real-World Evidence from the DATs-PD GETM Spanish Registry
- Symptomatic Pulmonary Regurgitation Without Right Ventricular Enlargement Accompanied by Biventricular Diastolic Dysfunction in Repaired Tetralogy of Fallot and Related Diseases
- Learning from implementation: health worker insights on strengthening immunisation data quality in Kampala’s lower-level private-for-profit health sector following implementation of a data quality improvement intervention
- Implementing a nurse-led care bundle to reduce indwelling pleural catheter-related complications: a quality improvement project
- Iron Supplementation Adherence and Satisfaction Among Adolescent Girls Following Point-of-Care Quality Improvement in an Indonesian Community Health Center Program: An Uncontrolled Pre–Post Study
BibTeX
@article{stack2026improvement,
title = {{Improvement in health-related quality of life after complex biventricular repair.}},
author = {Kathryn O Stack and Kimberlee Gauvreau and Sarah Campos and Michael S Bamgbose and Elizabeth D Blume and Sitaram M Emani and Ryan L Kobayashi and Rebecca S Beroukhim},
journal = {JTCVS open},
year = {2026},
month = jul,
doi = {10.1016/j.xjon.2026.101961},
url = {https://europepmc.org/article/MED/42948086},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Improvement in health-related quality of life after complex biventricular repair.
AU - Kathryn O Stack
AU - Kimberlee Gauvreau
AU - Sarah Campos
AU - Michael S Bamgbose
AU - Elizabeth D Blume
AU - Sitaram M Emani
AU - Ryan L Kobayashi
AU - Rebecca S Beroukhim
PY - 2026
DA - 2026/07/11
JO - JTCVS open
DO - 10.1016/j.xjon.2026.101961
UR - https://europepmc.org/article/MED/42948086
AB - Objective Complex biventricular (BiV) and one-and-a-half ventricle (1.5V) repairs are alternatives to single ventricle palliation. We describe 1 domain of the health-related quality of life of patients undergoing BiV and 1.5V repairs.Methods This single-center study included children (≤ 18 years) who underwent BiV or 1.5V repairs between October 1, 2022, and July 7, 2024. Parents completed Pediatric Quality of Life Inventory Infant Scales or Pediatric Quality of Life Inventory 3.0 Cardiac Modules; physical function and physical symptom scores for patients younger than 2 years and heart problems and treatment scores for patients 2 years and older were evaluated.Results Seventy-three patients, 36 younger than 2 years and 37 ages 2 years and older, were included. Forty-one patients (56%) underwent BiV surgery, and 32 (44%) underwent 1.5V surgery. Preoperatively, patients younger than 2 years had a mean physical symptom score of 76 ± 14 and a mean physical function score of 70 ± 20; patients ages 2 years and older had a mean heart problems and treatment score of 64 ± 20. Thirty-six patients, 10 younger than 2 years and 26 ages 2 years and older, had paired pre- and postoperative health-related quality of life data. Following repair, physical symptom scores improved among infants ages 0 to 12 months (mean, 67 vs 79; P = .033), and heart problems and treatment scores improved (ages 2 to 4 years, 69 vs 84; P = .002; ages 5 to 7 years, 57 vs 86; P = .044). For patients ages 2 years and older, 5 symptoms drove score improvement: exertional dyspnea, chest pain, tachycardia, cyanosis, and fatigue.Conclusions Six months after surgery, parents reported improvement in children's health-related quality of life following complex BiV or 1.5V repairs. Further work is needed to better understand long-term outcomes in this vulnerable population.
SN - 2666-2736
ER -