Peer-reviewedCC BY-NC-NDCirculation Journal
Symptomatic Pulmonary Regurgitation Without Right Ventricular Enlargement Accompanied by Biventricular Diastolic Dysfunction in Repaired Tetralogy of Fallot and Related Diseases
Abstract
BACKGROUND: In repaired tetralogy of Fallot (TOF) and related diseases, reoperation for pulmonary regurgitation (PR) may be delayed unless marked right ventricular (RV) enlargement is present. METHODS AND RESULTS: 32 patients with significant PR post-repair underwent catheterization and 4D flow MRI for reoperation evaluation. The Non-severe RV Dilation group (n=20) did not meet the surgical volume criteria, whereas the Severe RV Dilation group (n=12) did. The Non-severe RV Dilation group had higher biventricular filling pressures. The RV-Energy loss index in both groups was high. CONCLUSIONS: Diastolic dysfunction could serve as a therapeutic target in PR patients with heterogeneous etiologies.
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BibTeX
@article{yamabe2026symptomatic,
title = {{Symptomatic Pulmonary Regurgitation Without Right Ventricular Enlargement Accompanied by Biventricular Diastolic Dysfunction in Repaired Tetralogy of Fallot and Related Diseases}},
author = {Sayuri Yamabe and Kiyomi Kayama and Yoshiro Tsuruta and Yu Kawada and Tatsuya Mizoguchi and Masashi Yokoi and Kento Mori and Tsuyoshi Ito and Kyoko Matsui and Shuichi Kitada and Toshihiko Goto and Masahiro Yasuda and Hitomi Kimura and Satoshi Koyama and Tsutomu Shinohara and Keiichi Itatani and Yoshihiro Seo},
journal = {Circulation Journal},
year = {2026},
month = aug,
doi = {10.1253/circj.cj-25-0786},
url = {https://www.jstage.jst.go.jp/article/circj/90/9/90_CJ-25-0786/_article},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Symptomatic Pulmonary Regurgitation Without Right Ventricular Enlargement Accompanied by Biventricular Diastolic Dysfunction in Repaired Tetralogy of Fallot and Related Diseases
AU - Sayuri Yamabe
AU - Kiyomi Kayama
AU - Yoshiro Tsuruta
AU - Yu Kawada
AU - Tatsuya Mizoguchi
AU - Masashi Yokoi
AU - Kento Mori
AU - Tsuyoshi Ito
AU - Kyoko Matsui
AU - Shuichi Kitada
AU - Toshihiko Goto
AU - Masahiro Yasuda
AU - Hitomi Kimura
AU - Satoshi Koyama
AU - Tsutomu Shinohara
AU - Keiichi Itatani
AU - Yoshihiro Seo
PY - 2026
DA - 2026/08/25
JO - Circulation Journal
DO - 10.1253/circj.cj-25-0786
UR - https://www.jstage.jst.go.jp/article/circj/90/9/90_CJ-25-0786/_article
AB - BACKGROUND: In repaired tetralogy of Fallot (TOF) and related diseases, reoperation for pulmonary regurgitation (PR) may be delayed unless marked right ventricular (RV) enlargement is present. METHODS AND RESULTS: 32 patients with significant PR post-repair underwent catheterization and 4D flow MRI for reoperation evaluation. The Non-severe RV Dilation group (n=20) did not meet the surgical volume criteria, whereas the Severe RV Dilation group (n=12) did. The Non-severe RV Dilation group had higher biventricular filling pressures. The RV-Energy loss index in both groups was high. CONCLUSIONS: Diastolic dysfunction could serve as a therapeutic target in PR patients with heterogeneous etiologies.
SN - 1347-4820
SN - 1346-9843
ER -