Glutathione Depletion in Acute Respiratory Distress Syndrome: Mechanistic Significance and Potential Association with Ventilatory Support.
- 1College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, 309 E. Second St., Pomona, CA 91766, USA.
- 2Your Energy System, LLC, 555 Bryant St. #305, Palo Alto, CA 94301, USA.
Abstract
Acute Respiratory Distress Syndrome (ARDS) is a severe and life-threatening form of acute lung injury with high mortality. It affects approximately 150,000-190,000 patients annually in the United States, and a substantial proportion of patients require invasive mechanical ventilation for respiratory support. The progression of ARDS involves thrombo-inflammation, the disruption of the alveolar-capillary barrier, and oxidative injury within pulmonary tissues. Across diverse ARDS etiologies such as sepsis, aspiration, trauma, and COVID-19, the excessive production of reactive oxygen species (ROS) is a central mediator of lung injury. Central to the neutralization of oxidative stress is glutathione (GSH), a key intracellular antioxidant responsible for neutralizing ROS. Decreased levels of GSH have been associated with increased cytokine levels and thrombosis, but the full extent of GSH's role in these processes remains unclear. This review provides an overview of the role of glutathione in the pathophysiological sequelae of ARDS, highlights its relevance in COVID-19-related lung injury, and explores its potential as a clinical marker to predict the need for mechanical ventilation.
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BibTeX
@article{tran2026glutathione,
title = {{Glutathione Depletion in Acute Respiratory Distress Syndrome: Mechanistic Significance and Potential Association with Ventilatory Support.}},
author = {Brandon Tran and Elaine Nguyen and Srinivasan Karthikeyan and Shady Ibrahim and Frederick Timothy Guilford and Vishwanath Venketaraman},
journal = {International journal of molecular sciences},
year = {2026},
month = sep,
doi = {10.3390/ijms27198592},
url = {https://europepmc.org/article/MED/42883838},
note = {CC BY},
}
RIS
TY - JOUR
TI - Glutathione Depletion in Acute Respiratory Distress Syndrome: Mechanistic Significance and Potential Association with Ventilatory Support.
AU - Brandon Tran
AU - Elaine Nguyen
AU - Srinivasan Karthikeyan
AU - Shady Ibrahim
AU - Frederick Timothy Guilford
AU - Vishwanath Venketaraman
PY - 2026
DA - 2026/09/25
JO - International journal of molecular sciences
DO - 10.3390/ijms27198592
UR - https://europepmc.org/article/MED/42883838
AB - Acute Respiratory Distress Syndrome (ARDS) is a severe and life-threatening form of acute lung injury with high mortality. It affects approximately 150,000-190,000 patients annually in the United States, and a substantial proportion of patients require invasive mechanical ventilation for respiratory support. The progression of ARDS involves thrombo-inflammation, the disruption of the alveolar-capillary barrier, and oxidative injury within pulmonary tissues. Across diverse ARDS etiologies such as sepsis, aspiration, trauma, and COVID-19, the excessive production of reactive oxygen species (ROS) is a central mediator of lung injury. Central to the neutralization of oxidative stress is glutathione (GSH), a key intracellular antioxidant responsible for neutralizing ROS. Decreased levels of GSH have been associated with increased cytokine levels and thrombosis, but the full extent of GSH's role in these processes remains unclear. This review provides an overview of the role of glutathione in the pathophysiological sequelae of ARDS, highlights its relevance in COVID-19-related lung injury, and explores its potential as a clinical marker to predict the need for mechanical ventilation.
SN - 1422-0067
ER -