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Peer-reviewedCC BY 4.0Life Medicine

A framework of biomarkers for skin aging: a consensus statement by the Aging Biomarker Consortium

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Abstract

Skin is the largest organ of the human body and the first line of defense against the external environment. With the rapid growth of the older population in China, significant challenges have emerged in the prevention and management of age-associated diseases, while skin aging is closely associated with the aging of multiple organs. To address these challenges, the Aging Biomarker Consortium (ABC) has established an expert consensus on biomarkers of skin aging through a review of the literature and consultation with scientists and clinicians. This consensus provides a comprehensive evaluation of the key changes, characteristics, and biomarkers related to skin aging and proposes a systematic framework that categorizes these biomarkers into structural, functional, and humoral biomarkers. Within each dimension, the ABC recommends biomarkers supported by varying levels of clinical and experimental evidence for assessing both physiological and pathological changes in skin tissue during aging, aiming to establish a foundation for the prediction, diagnosis, early detection, and treatment of skin aging and related diseases, with the ultimate goal of improving skin tissue health and promoting healthy aging in elderly populations both in China and worldwide.

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BibTeX
@article{consortium2026framework,
  title = {{A framework of biomarkers for skin aging: a consensus statement by the Aging Biomarker Consortium}},
  author = {Aging Biomarker Consortium and Yiya Zhang and Mengting Chen and Zhijin Li and Yingxue Huang and Qian Zhao and Ting Chen and Xiang Chen and Yong Cui and Zhili Deng and Yanan Du and Xinhua Gao and Jing-Dong Jackie Han and Yujun Hou and Zhe Jian and Di Li and Hang Li and Zhimiao Lin and Hong Liu and Wenjing Luo and Yuling Shi and Liangdan Sun and Juan Tao and Yang Wang and Fang Wang and Haijing Wu and Ran Xiao and Yong Yang and Nanze Yu and Bing Zhang and Furen Zhang and Lingjuan Zhang and Weiqi Zhang and Ming Zhao and Guang-Hui Liu and Gang Pei and Xiao Long and Jing Qu and Ji Li},
  journal = {Life Medicine},
  year = {2026},
  month = oct,
  doi = {10.1093/lifemedi/lnag032},
  url = {https://doi.org/10.1093/lifemedi/lnag032},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - A framework of biomarkers for skin aging: a consensus statement by the Aging Biomarker Consortium
AU  - Aging Biomarker Consortium
AU  - Yiya Zhang
AU  - Mengting Chen
AU  - Zhijin Li
AU  - Yingxue Huang
AU  - Qian Zhao
AU  - Ting Chen
AU  - Xiang Chen
AU  - Yong Cui
AU  - Zhili Deng
AU  - Yanan Du
AU  - Xinhua Gao
AU  - Jing-Dong Jackie Han
AU  - Yujun Hou
AU  - Zhe Jian
AU  - Di Li
AU  - Hang Li
AU  - Zhimiao Lin
AU  - Hong Liu
AU  - Wenjing Luo
AU  - Yuling Shi
AU  - Liangdan Sun
AU  - Juan Tao
AU  - Yang Wang
AU  - Fang Wang
AU  - Haijing Wu
AU  - Ran Xiao
AU  - Yong Yang
AU  - Nanze Yu
AU  - Bing Zhang
AU  - Furen Zhang
AU  - Lingjuan Zhang
AU  - Weiqi Zhang
AU  - Ming Zhao
AU  - Guang-Hui Liu
AU  - Gang Pei
AU  - Xiao Long
AU  - Jing Qu
AU  - Ji Li
PY  - 2026
DA  - 2026/10/05
JO  - Life Medicine
DO  - 10.1093/lifemedi/lnag032
UR  - https://doi.org/10.1093/lifemedi/lnag032
AB  - Skin is the largest organ of the human body and the first line of defense against the external environment. With the rapid growth of the older population in China, significant challenges have emerged in the prevention and management of age-associated diseases, while skin aging is closely associated with the aging of multiple organs. To address these challenges, the Aging Biomarker Consortium (ABC) has established an expert consensus on biomarkers of skin aging through a review of the literature and consultation with scientists and clinicians. This consensus provides a comprehensive evaluation of the key changes, characteristics, and biomarkers related to skin aging and proposes a systematic framework that categorizes these biomarkers into structural, functional, and humoral biomarkers. Within each dimension, the ABC recommends biomarkers supported by varying levels of clinical and experimental evidence for assessing both physiological and pathological changes in skin tissue during aging, aiming to establish a foundation for the prediction, diagnosis, early detection, and treatment of skin aging and related diseases, with the ultimate goal of improving skin tissue health and promoting healthy aging in elderly populations both in China and worldwide.
SN  - 2755-1733
ER  -