From Solid-State Spin Defects to Fluorescent Proteins: A Perspective on Quantum Optical Sensing Platforms for Biomedical Applications
Abstract
Quantum optical sensing has evolved from isolated solid state spin defect platforms to increasingly bio-integrated systems designed for biomedical applications. This review presents a perspective on this transition, spanning nitrogen vacancy centers in diamond to emerging fluorescent protein based spin qubits. Advances in diamond fabrication have enabled photonic cavities, nanomechanical resonators, and microstructured devices that enhance spin photon interactions and room temperature sensitivity. Exploration of spin defects in alternative materials further expands the sensing landscape. Parallel progress toward biological compatibility includes chip based architectures for in vitro and in vivo studies, microfluidic integration, and minimally invasive nanodiamond probes capable of intracellular nanothermometry and nanorheometry. Improvements in surface functionalization have enhanced coherence and sensing reliability in complex environments. Collectively, these advances highlight the progress and remaining challenges toward application oriented quantum sensing for the life sciences.
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BibTeX
@misc{parhi2026from,
title = {{From Solid-State Spin Defects to Fluorescent Proteins: A Perspective on Quantum Optical Sensing Platforms for Biomedical Applications}},
author = {Jyotiprakash Parhi and Ayan Majumder and Kasturi Saha},
howpublished = {arXiv},
year = {2026},
month = oct,
doi = {10.48550/arxiv.2610.11644},
eprint = {2610.11644},
archivePrefix = {arXiv},
url = {https://arxiv.org/abs/2610.11644},
note = {CC BY 4.0},
}
RIS
TY - UNPB
TI - From Solid-State Spin Defects to Fluorescent Proteins: A Perspective on Quantum Optical Sensing Platforms for Biomedical Applications
AU - Jyotiprakash Parhi
AU - Ayan Majumder
AU - Kasturi Saha
PY - 2026
DA - 2026/10/08
PB - arXiv
DO - 10.48550/arxiv.2610.11644
UR - https://arxiv.org/abs/2610.11644
AB - Quantum optical sensing has evolved from isolated solid state spin defect platforms to increasingly bio-integrated systems designed for biomedical applications. This review presents a perspective on this transition, spanning nitrogen vacancy centers in diamond to emerging fluorescent protein based spin qubits. Advances in diamond fabrication have enabled photonic cavities, nanomechanical resonators, and microstructured devices that enhance spin photon interactions and room temperature sensitivity. Exploration of spin defects in alternative materials further expands the sensing landscape. Parallel progress toward biological compatibility includes chip based architectures for in vitro and in vivo studies, microfluidic integration, and minimally invasive nanodiamond probes capable of intracellular nanothermometry and nanorheometry. Improvements in surface functionalization have enhanced coherence and sensing reliability in complex environments. Collectively, these advances highlight the progress and remaining challenges toward application oriented quantum sensing for the life sciences.
ER -