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Peer-reviewedCC BYFrontiers in cardiovascular medicine

Trends in mortality due to acute myocardial infarction and pneumonia among older adults in the U.S.: a CDC wonder analysis (1999-2023)

  • Shuai Feng1
  • Lianghao Zhang1
  • Lin Quan2
  • Nannan Jiang2
  • Ziyi Zhao3
  • Hongxiang Ji4
  • Chuanshen Xu1
  • Jinquan Liu1
4 affiliations
  1. 1Organ Transplantation Center, The Affiliated Hospital of Qingdao University , , ,
  2. 2Department of Orthopaedics, The Affiliated Hospital of Qingdao University , , ,
  3. 3Department of Hand and Foot, Microsurgery, The Affiliated Hospital of Qingdao University , , ,
  4. 4The First Clinical Medical College, Shandong University of Traditional Chinese Medicine , , ,
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Abstract

Objective: This study aims to assess the comprehensive national trends in deaths related to pneumonia and AMI in the US from 1999 to 2023.

Methods: CDC wonder multiple cause of death database was used to extract data of elderly (≥65 years) with pneumonia and AMI as main or contributing cause of death. Age-Adjusted Mortality Rates (AAMRs) per 100,000 population were calculated. Trends were stratified by sex, race/ethnicity, state, urban-rural classification, census region, ten-year age group, and place of death.

Results: A total of 186,411 deaths associated with pneumonia and AMI during 1999-2023 were identified. The cumulative AAMR was 17.76 during 1999-2020, and 14.2 during 2021-2023. A significant decline in AAMR was found through the study period (AAPC:-4.26, 95% CI −6.71 to -1.74). The AAMR of men was higher than women, and the decrease of AAMR was steeper in women (AAPC:-4.38, 95% CI -6.78 to -1.92 among women vs. -4.07, 95% CI -5.68 to -2.43 among men). NH American Indian or Alaska Native has the highest AAMR, while NH Asian or Pacific Islander had the lowest AAPC (-5.03, 95% CI -7.95 to -2.02). Non-metropolitan had higher AAMR (22.93 vs. 16.59) and AAPC (-1.69 vs. -3.51) than metropolitan. South region showed the highest AAMR and AAPC compared to other census regions.

Conclusions: The AAMR per 100,000 of pneumonia and AMI decreased among older adults in the US during 1999-2023, with higher mortality burden among men, NH American Indian or Alaska Native, rural area, and South region.

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Cite

BibTeXRIS
BibTeX
@article{feng2026trends,
  title = {{Trends in mortality due to acute myocardial infarction and pneumonia among older adults in the U.S.: a CDC wonder analysis (1999-2023)}},
  author = {Shuai Feng and Lianghao Zhang and Lin Quan and Nannan Jiang and Ziyi Zhao and Hongxiang Ji and Chuanshen Xu and Jinquan Liu},
  journal = {Frontiers in cardiovascular medicine},
  year = {2026},
  month = sep,
  doi = {10.3389/fcvm.2026.1913867},
  url = {https://europepmc.org/article/PMC/PMC13661469},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Trends in mortality due to acute myocardial infarction and pneumonia among older adults in the U.S.: a CDC wonder analysis (1999-2023)
AU  - Shuai Feng
AU  - Lianghao Zhang
AU  - Lin Quan
AU  - Nannan Jiang
AU  - Ziyi Zhao
AU  - Hongxiang Ji
AU  - Chuanshen Xu
AU  - Jinquan Liu
PY  - 2026
DA  - 2026/09/30
JO  - Frontiers in cardiovascular medicine
DO  - 10.3389/fcvm.2026.1913867
UR  - https://europepmc.org/article/PMC/PMC13661469
AB  - Objective: This study aims to assess the comprehensive national trends in deaths related to pneumonia and AMI in the US from 1999 to 2023.  Methods: CDC wonder multiple cause of death database was used to extract data of elderly (≥65 years) with pneumonia and AMI as main or contributing cause of death. Age-Adjusted Mortality Rates (AAMRs) per 100,000 population were calculated. Trends were stratified by sex, race/ethnicity, state, urban-rural classification, census region, ten-year age group, and place of death.  Results: A total of 186,411 deaths associated with pneumonia and AMI during 1999-2023 were identified. The cumulative AAMR was 17.76 during 1999-2020, and 14.2 during 2021-2023. A significant decline in AAMR was found through the study period (AAPC:-4.26, 95% CI −6.71 to -1.74). The AAMR of men was higher than women, and the decrease of AAMR was steeper in women (AAPC:-4.38, 95% CI -6.78 to -1.92 among women vs. -4.07, 95% CI -5.68 to -2.43 among men). NH American Indian or Alaska Native has the highest AAMR, while NH Asian or Pacific Islander had the lowest AAPC (-5.03, 95% CI -7.95 to -2.02). Non-metropolitan had higher AAMR (22.93 vs. 16.59) and AAPC (-1.69 vs. -3.51) than metropolitan. South region showed the highest AAMR and AAPC compared to other census regions.  Conclusions: The AAMR per 100,000 of pneumonia and AMI decreased among older adults in the US during 1999-2023, with higher mortality burden among men, NH American Indian or Alaska Native, rural area, and South region.
SN  - 2297-055X
ER  -