Peer-reviewedCC BY-NC 4.0Infection and Drug Resistance27 Oct 2026

Epidemiology, Clinical Profiles, Antimicrobial Resistance, and Inflammatory Risk Factors of Aeromonas Infections in Hospitalized Patients: A Retrospective Cohort Study from a Hospital in Zhoushan Archipelago, China

Yuechuan Shen¹
Hui He²
Ziyun Lin¹
Jiayao Chen³
Guangfeng Zhao¹
Zhoubo Wang¹
Zhuoqun Li¹

¹Emergency Department, Zhoushan Hospital of Zhejiang Province, Zhoushan, Zhejiang, 316021, People’s Republic of China
²Pathology Department, Zhoushan Hospital of Zhejiang Province, Zhoushan, Zhejiang, 316021, People’s Republic of China
³Clinical Laboratory, Zhoushan Hospital of Zhejiang Province, Zhoushan, Zhejiang, 316021, People’s Republic of China

Abstract

Objective: This study aimed to investigate the species distribution, clinical manifestations, antimicrobial susceptibility, and mortality-related inflammatory risk factors of Aeromonas infections in the Zhoushan Archipelago, China.

Methods: A retrospective cohort study was conducted on Aeromonas strains isolated from clinical specimens between 2019 and 2024. Species were identified using MALDI-TOF MS, and antimicrobial susceptibility was tested via VITEK 2 Compact.

Results: Among 173 cases, A. sobria (31.21%) and A. hydrophila (31.79%) were predominant. A. sobria was associated with a significantly higher rate of poor prognosis (9.26% vs 1.68%). All 7 fatal cases developed sepsis and displayed severe systemic inflammation, evidenced by sharply decreased red blood cells, platelets, and albumin, as well as elevated creatinine (all P < 0.01). A. hydrophila showed higher resistance to cefazolin and cefoxitin, while amikacin and tobramycin remained highly susceptible.

Conclusion: In the Zhoushan Archipelago, A. sobria poses a pronounced lethal risk, particularly in immunocompromised patients, through rapid progression to septic shock driven by unchecked inflammatory responses. Ceftazidime combined with amikacin is recommended as empirical therapy. The study highlights the need to monitor early inflammatory markers for improving outcomes.

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BibTeX RIS

BibTeX

@article{shen2026epidemiology,
  title = {{Epidemiology, Clinical Profiles, Antimicrobial Resistance, and Inflammatory Risk Factors of Aeromonas Infections in Hospitalized Patients: A Retrospective Cohort Study from a Hospital in Zhoushan Archipelago, China}},
  author = {Yuechuan Shen and Hui He and Ziyun Lin and Jiayao Chen and Guangfeng Zhao and Zhoubo Wang and Zhuoqun Li},
  journal = {Infection and Drug Resistance},
  year = {2026},
  month = oct,
  doi = {10.2147/idr.s637748},
  url = {https://doi.org/10.2147/idr.s637748},
  note = {CC BY-NC 4.0},
}

RIS

TY  - JOUR
TI  - Epidemiology, Clinical Profiles, Antimicrobial Resistance, and Inflammatory Risk Factors of Aeromonas Infections in Hospitalized Patients: A Retrospective Cohort Study from a Hospital in Zhoushan Archipelago, China
AU  - Yuechuan Shen
AU  - Hui He
AU  - Ziyun Lin
AU  - Jiayao Chen
AU  - Guangfeng Zhao
AU  - Zhoubo Wang
AU  - Zhuoqun Li
PY  - 2026
DA  - 2026/10/27
JO  - Infection and Drug Resistance
DO  - 10.2147/idr.s637748
UR  - https://doi.org/10.2147/idr.s637748
AB  - Objective: This study aimed to investigate the species distribution, clinical manifestations, antimicrobial susceptibility, and mortality-related inflammatory risk factors of Aeromonas infections in the Zhoushan Archipelago, China.  Methods: A retrospective cohort study was conducted on Aeromonas strains isolated from clinical specimens between 2019 and 2024. Species were identified using MALDI-TOF MS, and antimicrobial susceptibility was tested via VITEK 2 Compact.  Results: Among 173 cases, A. sobria (31.21%) and A. hydrophila (31.79%) were predominant. A. sobria was associated with a significantly higher rate of poor prognosis (9.26% vs 1.68%). All 7 fatal cases developed sepsis and displayed severe systemic inflammation, evidenced by sharply decreased red blood cells, platelets, and albumin, as well as elevated creatinine (all P < 0.01). A. hydrophila showed higher resistance to cefazolin and cefoxitin, while amikacin and tobramycin remained highly susceptible.  Conclusion: In the Zhoushan Archipelago, A. sobria poses a pronounced lethal risk, particularly in immunocompromised patients, through rapid progression to septic shock driven by unchecked inflammatory responses. Ceftazidime combined with amikacin is recommended as empirical therapy. The study highlights the need to monitor early inflammatory markers for improving outcomes.
SN  - 1178-6973
ER  -

Abstract

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