Pharmacological Modulators of TCTP: Opportunities and Challenges for Drug Repurposing
Abstract
Thanks to the rapid development of advanced analytical methods, researchers can now identify new, so far unknown applications for existing drugs. This expanding knowledge about the mechanisms of drug action, including interactions with various molecules and molecular pathways, not only enables more effective use of available therapies but also reduces both the time and cost of developing new therapeutic options. One of the proteins reported to interact with numerous drugs and chemicals is Translationally Controlled Tumor Protein (TCTP). Numerous studies have demonstrated that TCTP plays a crucial role in diverse biological processes, including cell growth, cell cycle regulation, cellular proliferation, allergic reactions, stress response, inhibition of apoptosis, calcium ion binding, interacting with microtubules and actin microfilaments, the progression of various cancers, and tumor reversion. Therefore, this review article aims to compile a list of drugs and substances shown to interact with TCTP and that, given TCTP’s numerous cellular functions, could be repurposed for other therapies.
Related
- Tumor microenvironment-driven immune evasion in triple-negative breast cancer: mechanisms, clinical challenges, and therapeutic opportunities
- Grounding meaning in social and emotional experience: Challenges and opportunities
- Central Nervous System Reservoirs and HIV Cure: Therapeutic Opportunities and Challenges.
- Federated Causal Discovery in Medicine: Trends, Opportunities, and Challenges
- Smart Farming for Small Farms: Technologies, Challenges, and Opportunities for Small-Scale Producers
BibTeX
@article{andrzejczyk2026pharmacological,
title = {{Pharmacological Modulators of TCTP: Opportunities and Challenges for Drug Repurposing}},
author = {Weronika Andrzejczyk and Klaudia Porebska and Thananjeyan Balasubramaniyam and Agnieszka Synowiec and Malgorzata Kloc and Paweł Stączek and Jacek Z. Kubiak},
journal = {International Journal of Molecular Sciences},
year = {2026},
month = aug,
doi = {10.3390/ijms27167161},
url = {https://hal.science/hal-05746942v1},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Pharmacological Modulators of TCTP: Opportunities and Challenges for Drug Repurposing
AU - Weronika Andrzejczyk
AU - Klaudia Porebska
AU - Thananjeyan Balasubramaniyam
AU - Agnieszka Synowiec
AU - Malgorzata Kloc
AU - Paweł Stączek
AU - Jacek Z. Kubiak
PY - 2026
DA - 2026/08/11
JO - International Journal of Molecular Sciences
DO - 10.3390/ijms27167161
UR - https://hal.science/hal-05746942v1
AB - Thanks to the rapid development of advanced analytical methods, researchers can now identify new, so far unknown applications for existing drugs. This expanding knowledge about the mechanisms of drug action, including interactions with various molecules and molecular pathways, not only enables more effective use of available therapies but also reduces both the time and cost of developing new therapeutic options. One of the proteins reported to interact with numerous drugs and chemicals is Translationally Controlled Tumor Protein (TCTP). Numerous studies have demonstrated that TCTP plays a crucial role in diverse biological processes, including cell growth, cell cycle regulation, cellular proliferation, allergic reactions, stress response, inhibition of apoptosis, calcium ion binding, interacting with microtubules and actin microfilaments, the progression of various cancers, and tumor reversion. Therefore, this review article aims to compile a list of drugs and substances shown to interact with TCTP and that, given TCTP’s numerous cellular functions, could be repurposed for other therapies.
SN - 1661-6596
SN - 1422-0067
ER -