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Peer-reviewedCC BY 4.0PLOS One

LED red light therapy for relief of primary dysmenorrhea: An open, single-group target value clinical trial

  • Bin Yi1
  • Dandan Wang2
  • Ling Wei3
  • Jun He4
  • Qian Yu
  • Lei Wu
  • Yilin Wang
  • Yajuan Wang
  • Nan Song
  • Li Guo
4 affiliations
  1. 1Beijing Charmwin Light Medical Technology Co., Ltd., Beijing, China
  2. 2Department of Gynecology and Obstetrics, The First Affiliated Hospital of Baotou Medical College, Baotou, China
  3. 3Department of Gynecology, Hebei PetroChina Central Hospital, Langfang, China
  4. 4Department of Dermatology, Chinese PLA General Hospital, Beijing, China
Open at sourcePDFDOICite

Abstract

Objective: To evaluate the efficacy and safety of LED red light therapy in alleviating primary dysmenorrhea. Methods: A total of 119 patients with primary dysmenorrhea were enrolled in 2022. The intervention was LED red light therapy administered 7 days before menstruation. Clinical outcomes were assessed after three menstrual cycles. Results: After three cycles of treatment, the mean reduction rate in the Visual Analog Scale (VAS) score was 63.62%. The overall effective rate of the device was 98.32%. The total score of the COX Menstrual Symptom Scale decreased by 72.93%, with specific reductions of 72.55% in symptom severity and 73.26% in pain duration. No severe adverse events were reported during the trial. Only one adverse event (0.84%) was considered device-related. Conclusion: LED red light therapy is safe and effective for the treatment of primary dysmenorrhea. Trial registration: ChiCTR2600116460.

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Cite

BibTeXRIS
BibTeX
@article{yi2026light,
  title = {{LED red light therapy for relief of primary dysmenorrhea: An open, single-group target value clinical trial}},
  author = {Bin Yi and Dandan Wang and Ling Wei and Jun He and Qian Yu and Lei Wu and Yilin Wang and Yajuan Wang and Nan Song and Li Guo},
  journal = {PLOS One},
  year = {2026},
  month = sep,
  doi = {10.1371/journal.pone.0356618},
  url = {https://doi.org/10.1371/journal.pone.0356618},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - LED red light therapy for relief of primary dysmenorrhea: An open, single-group target value clinical trial
AU  - Bin Yi
AU  - Dandan Wang
AU  - Ling Wei
AU  - Jun He
AU  - Qian Yu
AU  - Lei Wu
AU  - Yilin Wang
AU  - Yajuan Wang
AU  - Nan Song
AU  - Li Guo
PY  - 2026
DA  - 2026/09/01
JO  - PLOS One
DO  - 10.1371/journal.pone.0356618
UR  - https://doi.org/10.1371/journal.pone.0356618
AB  - Objective: To evaluate the efficacy and safety of LED red light therapy in alleviating primary dysmenorrhea. Methods: A total of 119 patients with primary dysmenorrhea were enrolled in 2022. The intervention was LED red light therapy administered 7 days before menstruation. Clinical outcomes were assessed after three menstrual cycles. Results: After three cycles of treatment, the mean reduction rate in the Visual Analog Scale (VAS) score was 63.62%. The overall effective rate of the device was 98.32%. The total score of the COX Menstrual Symptom Scale decreased by 72.93%, with specific reductions of 72.55% in symptom severity and 73.26% in pain duration. No severe adverse events were reported during the trial. Only one adverse event (0.84%) was considered device-related. Conclusion: LED red light therapy is safe and effective for the treatment of primary dysmenorrhea. Trial registration: ChiCTR2600116460.
SN  - 1932-6203
ER  -