Clinical Manifestations and Outcomes of Hospitalized Patients With Blastomycosis: A Provincial Cohort Study.
7 affiliations
- 1Department of Internal Medicine, Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.
- 2Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Manitoba, Canada.
- 3George and Fay Yee Centre for Healthcare Innovation, University of Manitoba, Winnipeg, Manitoba, Canada.
- 4Winnipeg Regional Health Authority, Winnipeg, Manitoba, Canada.
- 5College of Community and Global Health, University of Manitoba, Winnipeg, Manitoba, Canada.
- 6CancerCare Manitoba, Winnipeg, Manitoba, Canada.
- 7Diagnostic Services, Shared Health, Winnipeg, Manitoba, Canada.
Abstract
Background
Blastomycosis is a rare but potentially life-threatening infection caused by Blastomyces spp that is endemic in the Canadian provinces of Manitoba and northwestern Ontario. Given evolving epidemiology of endemic mycoses, we sought to evaluate the provincial experience managing inpatients with blastomycosis over time. The objectives were to describe the risk factors and predictors of poor outcomes among patients hospitalized with blastomycosis throughout Manitoba.Methods
We performed a provincial retrospective cohort study by identifying all culture-positive clinical specimens yielding Blastomyces spp within Manitoba, using the Provincial Lab Information System. We included all adult patients who required admission to hospital for infectious manifestations of microbiologically confirmed blastomycosis since 2006. We used a multivariate regression model to predict associations with mortality.Results
Of 317 patients with culture-positive Blastomyces spp, we included 141 hospitalized patients across 7 hospitals. Overall, in-hospital mortality was 24%. The presence of chest pain at presentation to hospital (odds ratio, 3.24 [95% confidence interval, 1.26-8.83]) was associated with mortality. Hospital admissions, intensive care unit admissions, and mortality have a positive temporal trend over the study period.Conclusions
Blastomycosis is associated with significant morbidity and mortality, both of which is increased over time. Further studies are needed to evaluate effective diagnostic and treatment strategies to improve outcomes.
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BibTeX
@article{meyers2026clinical,
title = {{Clinical Manifestations and Outcomes of Hospitalized Patients With Blastomycosis: A Provincial Cohort Study.}},
author = {Benjamin Meyers and John Embil and Robert Balshaw and Barret Rush and Christina Tarrant and Kevin Thomas and Tyler MacDonald and Terence Wuerz and Yoav Keynan and Ryan Zarychanski and Philippe Lagacé-Wiens and Sylvain A Lother},
journal = {Open forum infectious diseases},
year = {2026},
month = oct,
doi = {10.1093/ofid/ofag656},
url = {https://europepmc.org/article/MED/42909872},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Clinical Manifestations and Outcomes of Hospitalized Patients With Blastomycosis: A Provincial Cohort Study.
AU - Benjamin Meyers
AU - John Embil
AU - Robert Balshaw
AU - Barret Rush
AU - Christina Tarrant
AU - Kevin Thomas
AU - Tyler MacDonald
AU - Terence Wuerz
AU - Yoav Keynan
AU - Ryan Zarychanski
AU - Philippe Lagacé-Wiens
AU - Sylvain A Lother
PY - 2026
DA - 2026/10/09
JO - Open forum infectious diseases
DO - 10.1093/ofid/ofag656
UR - https://europepmc.org/article/MED/42909872
AB - Background Blastomycosis is a rare but potentially life-threatening infection caused by Blastomyces spp that is endemic in the Canadian provinces of Manitoba and northwestern Ontario. Given evolving epidemiology of endemic mycoses, we sought to evaluate the provincial experience managing inpatients with blastomycosis over time. The objectives were to describe the risk factors and predictors of poor outcomes among patients hospitalized with blastomycosis throughout Manitoba.Methods We performed a provincial retrospective cohort study by identifying all culture-positive clinical specimens yielding Blastomyces spp within Manitoba, using the Provincial Lab Information System. We included all adult patients who required admission to hospital for infectious manifestations of microbiologically confirmed blastomycosis since 2006. We used a multivariate regression model to predict associations with mortality.Results Of 317 patients with culture-positive Blastomyces spp, we included 141 hospitalized patients across 7 hospitals. Overall, in-hospital mortality was 24%. The presence of chest pain at presentation to hospital (odds ratio, 3.24 [95% confidence interval, 1.26-8.83]) was associated with mortality. Hospital admissions, intensive care unit admissions, and mortality have a positive temporal trend over the study period.Conclusions Blastomycosis is associated with significant morbidity and mortality, both of which is increased over time. Further studies are needed to evaluate effective diagnostic and treatment strategies to improve outcomes.
SN - 2328-8957
ER -