Role of intermittent hypoxia in the dysregulation of serum uric acid levels in non-obese adults with obstructive sleep apnea syndrome
- 1Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital, Fujian Medical University
Abstract
This study investigated the association between serum uric acid (SUA) and obstructive sleep apnea syndrome (OSAS) and identified risk factors for elevated SUA in non-obese patients. Consecutive non-obese patients referred to the sleep center for suspected OSAS were included. Correlation, multiple linear regression, multivariable logistic regression, and ROC analyses were performed. A total of 291 participants were included. SUA levels differed significantly among groups stratified by OSAS severity (p = 0.008). The prevalence of hyperuricemia also differed significantly across OSAS severity categories (χ²=8.079, p = 0.044). Neck circumference, male sex, BMI, triglycerides, AHI, TS90%, ODI, mean SpO₂, and LaSO₂ correlated with SUA (all p < 0.05). ODI (β = 0.192, p < 0.001), and urea (β = 0.172, p = 0.002) were positively associated with SUA, whereas eGFR (β =-0.264, p = 0.001) was inversely associated with SUA. ODI remained independently associated with hyperuricemia in logistic regression analysis (OR = 1.027, 95% CI 1.008–1.046, p = 0.006). In ROC analysis, the area under the curve increased from 0.695 for the base model to 0.722 after ODI was included. Non-obese patients with OSAS had elevated SUA levels, and ODI was independently associated with both continuous SUA levels and hyperuricemia. These findings suggest that intermittent hypoxia is associated with impaired uric acid regulation in non-obese individuals with OSAS. Prospective studies are needed to establish a causal relationship.
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BibTeX
@article{lin2026role,
title = {{Role of intermittent hypoxia in the dysregulation of serum uric acid levels in non-obese adults with obstructive sleep apnea syndrome}},
author = {Ting Lin and Jie-Feng Huang and Jian-Ming Zhao and Li-Fang Fu and Mei-Xin Nian and Bi-Ying Wang and Gong-Ping Chen},
journal = {Scientific Reports},
year = {2026},
month = aug,
doi = {10.1038/s41598-026-66359-7},
url = {https://doi.org/10.1038/s41598-026-66359-7},
note = {CC BY},
}
RIS
TY - JOUR
TI - Role of intermittent hypoxia in the dysregulation of serum uric acid levels in non-obese adults with obstructive sleep apnea syndrome
AU - Ting Lin
AU - Jie-Feng Huang
AU - Jian-Ming Zhao
AU - Li-Fang Fu
AU - Mei-Xin Nian
AU - Bi-Ying Wang
AU - Gong-Ping Chen
PY - 2026
DA - 2026/08/01
JO - Scientific Reports
DO - 10.1038/s41598-026-66359-7
UR - https://doi.org/10.1038/s41598-026-66359-7
AB - This study investigated the association between serum uric acid (SUA) and obstructive sleep apnea syndrome (OSAS) and identified risk factors for elevated SUA in non-obese patients. Consecutive non-obese patients referred to the sleep center for suspected OSAS were included. Correlation, multiple linear regression, multivariable logistic regression, and ROC analyses were performed. A total of 291 participants were included. SUA levels differed significantly among groups stratified by OSAS severity (p = 0.008). The prevalence of hyperuricemia also differed significantly across OSAS severity categories (χ²=8.079, p = 0.044). Neck circumference, male sex, BMI, triglycerides, AHI, TS90%, ODI, mean SpO₂, and LaSO₂ correlated with SUA (all p < 0.05). ODI (β = 0.192, p < 0.001), and urea (β = 0.172, p = 0.002) were positively associated with SUA, whereas eGFR (β =-0.264, p = 0.001) was inversely associated with SUA. ODI remained independently associated with hyperuricemia in logistic regression analysis (OR = 1.027, 95% CI 1.008–1.046, p = 0.006). In ROC analysis, the area under the curve increased from 0.695 for the base model to 0.722 after ODI was included. Non-obese patients with OSAS had elevated SUA levels, and ODI was independently associated with both continuous SUA levels and hyperuricemia. These findings suggest that intermittent hypoxia is associated with impaired uric acid regulation in non-obese individuals with OSAS. Prospective studies are needed to establish a causal relationship.
SN - 2045-2322
ER -