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PreprintCC BY-NCbioRxiv

Rearrangement of chromosome spatial organization in mouse zygotes using optical tweezers does not affect preimplantation development

  • C. Mollier
  • O. Kastas
  • L. de Chancel
  • J. Roensch
  • L. Kolar-Znika
  • A. de Cian
  • M. Dahan
  • D. Fachinetti
  • A. Coulon
  • J.-L. Maitre1
  1. 1Institut Curie
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Abstract

The spatial arrangement of chromosomes is thought to influence key processes such as gene expression or chromosome segregation. However, the contribution of chromosome spatial organization in physiological contexts remains disputed. Here, we use optical tweezers to displace nucleoli and physically rearrange the nuclear contents of mouse zygotes. Monitoring the preimplantation development of zygotes with physically shuffled nuclei reveals that cell dynamics, gene expression and overall blastocyst formation are not affected. This suggests that in mouse zygotes, the spatial organisation of chromosomes is not critical for blastocyst development.

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Cite

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BibTeX
@misc{mollier2026rearrangement,
  title = {{Rearrangement of chromosome spatial organization in mouse zygotes using optical tweezers does not affect preimplantation development}},
  author = {C. Mollier and O. Kastas and L. de Chancel and J. Roensch and L. Kolar-Znika and A. de Cian and M. Dahan and D. Fachinetti and A. Coulon and J.-L. Maitre},
  howpublished = {bioRxiv},
  year = {2026},
  month = oct,
  doi = {10.64898/2026.10.26.761794},
  url = {https://www.biorxiv.org/content/10.64898/2026.10.26.761794v1},
  note = {CC BY-NC},
}
RIS
TY  - UNPB
TI  - Rearrangement of chromosome spatial organization in mouse zygotes using optical tweezers does not affect preimplantation development
AU  - C. Mollier
AU  - O. Kastas
AU  - L. de Chancel
AU  - J. Roensch
AU  - L. Kolar-Znika
AU  - A. de Cian
AU  - M. Dahan
AU  - D. Fachinetti
AU  - A. Coulon
AU  - J.-L. Maitre
PY  - 2026
DA  - 2026/10/26
PB  - bioRxiv
DO  - 10.64898/2026.10.26.761794
UR  - https://www.biorxiv.org/content/10.64898/2026.10.26.761794v1
AB  - The spatial arrangement of chromosomes is thought to influence key processes such as gene expression or chromosome segregation. However, the contribution of chromosome spatial organization in physiological contexts remains disputed. Here, we use optical tweezers to displace nucleoli and physically rearrange the nuclear contents of mouse zygotes. Monitoring the preimplantation development of zygotes with physically shuffled nuclei reveals that cell dynamics, gene expression and overall blastocyst formation are not affected. This suggests that in mouse zygotes, the spatial organisation of chromosomes is not critical for blastocyst development.
ER  -