Giant Cell Tumor of Bone in the Geriatric Population: A Comprehensive Study of Survivorship, Recurrence, and Functional Outcomes.
- 1Department of Orthopaedics, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.
Abstract
Giant cell tumor (GCT) of bone predominantly affects young adults, whereas its occurrence in patients aged 70 years and older is uncommon. Limited evidence exists regarding its clinical presentation, treatment, recurrence, and functional outcomes in this age group. This study evaluated the clinical characteristics, treatment outcomes, and functional recovery of geriatric patients with GCT of bone. A prospective observational study was conducted at a tertiary care referral center between January 2020 and January 2024. Patients aged ≥70 years with histologically confirmed GCT of bone who underwent surgical treatment and had a minimum follow-up of 24 months were included. Demographic, clinical, radiological, surgical, and follow-up data were recorded. Tumors were classified according to the Campanacci grading system. Functional outcome was assessed using the musculoskeletal tumor society (MSTS) score. Patients underwent serial clinical and radiological surveillance for local recurrence and pulmonary metastasis. Eight patients were included, with a mean age of 75.0 ± 3.9 years (range, 70-81 years); four were male and four female. All tumors were Campanacci grade III. Six tumors (75%) involved the proximal tibia and two (25%) the distal femur. Four patients (50%) presented with recurrent disease. One patient had secondary sarcomatous transformation with pulmonary metastasis and died from metastatic disease-related complications. Extended curettage with reconstruction was performed in selected patients, while wide resection with endoprosthetic reconstruction was used for extensive or recurrent disease. Mean follow-up was 26.4 ± 3.1 months, and mean final MSTS score was 18.1 ± 6.4. No new local recurrence was documented after treatment at our institution. GCT of bone can rarely occur in patients aged ≥70 years and may present with advanced or recurrent disease. Careful histopathological diagnosis, staging, and individualized surgical planning are essential. Wide resection with endoprosthetic reconstruction may be appropriate for selected recurrent or extensive tumors.
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BibTeX
@article{kantiwal2026giant,
title = {{Giant Cell Tumor of Bone in the Geriatric Population: A Comprehensive Study of Survivorship, Recurrence, and Functional Outcomes.}},
author = {Prabodh Kantiwal and Vimal Prakash and Amir Suhail and Bharat Kumar Soni and Furqan Meer and V L Nikhil},
journal = {Journal of orthopaedic case reports},
year = {2026},
month = nov,
doi = {10.13107/jocr.2026.v16.i11.8508},
url = {https://europepmc.org/article/MED/42997094},
note = {CC BY-NC},
}
RIS
TY - JOUR
TI - Giant Cell Tumor of Bone in the Geriatric Population: A Comprehensive Study of Survivorship, Recurrence, and Functional Outcomes.
AU - Prabodh Kantiwal
AU - Vimal Prakash
AU - Amir Suhail
AU - Bharat Kumar Soni
AU - Furqan Meer
AU - V L Nikhil
PY - 2026
DA - 2026/11/01
JO - Journal of orthopaedic case reports
DO - 10.13107/jocr.2026.v16.i11.8508
UR - https://europepmc.org/article/MED/42997094
AB - Giant cell tumor (GCT) of bone predominantly affects young adults, whereas its occurrence in patients aged 70 years and older is uncommon. Limited evidence exists regarding its clinical presentation, treatment, recurrence, and functional outcomes in this age group. This study evaluated the clinical characteristics, treatment outcomes, and functional recovery of geriatric patients with GCT of bone. A prospective observational study was conducted at a tertiary care referral center between January 2020 and January 2024. Patients aged ≥70 years with histologically confirmed GCT of bone who underwent surgical treatment and had a minimum follow-up of 24 months were included. Demographic, clinical, radiological, surgical, and follow-up data were recorded. Tumors were classified according to the Campanacci grading system. Functional outcome was assessed using the musculoskeletal tumor society (MSTS) score. Patients underwent serial clinical and radiological surveillance for local recurrence and pulmonary metastasis. Eight patients were included, with a mean age of 75.0 ± 3.9 years (range, 70-81 years); four were male and four female. All tumors were Campanacci grade III. Six tumors (75%) involved the proximal tibia and two (25%) the distal femur. Four patients (50%) presented with recurrent disease. One patient had secondary sarcomatous transformation with pulmonary metastasis and died from metastatic disease-related complications. Extended curettage with reconstruction was performed in selected patients, while wide resection with endoprosthetic reconstruction was used for extensive or recurrent disease. Mean follow-up was 26.4 ± 3.1 months, and mean final MSTS score was 18.1 ± 6.4. No new local recurrence was documented after treatment at our institution. GCT of bone can rarely occur in patients aged ≥70 years and may present with advanced or recurrent disease. Careful histopathological diagnosis, staging, and individualized surgical planning are essential. Wide resection with endoprosthetic reconstruction may be appropriate for selected recurrent or extensive tumors.
SN - 2250-0685
SN - 2321-3817
ER -