Skip to content
DraconiticResearch
Search Sources API
203,234 studies31 sourcesUpdated 16 min ago
Peer-reviewedLicence not statedScience Advances

Atomic structure and dynamics of the mechanosensitive channel MscL from Escherichia coli by cryo-EM and solid-state NMR

  • Taoran Xiao1
  • Alexandra Kovinko1
  • Chaowei Shi1,2
  • Henry Sawczyc1
  • Denis Qoraj1
  • Carl Öster1
  • Thiemo Sprink3,4
  • Anton F. Ketzel5,6
  • Sascha Lange1
  • Spyridon Kosteletos1
  • Han Sun5,6
  • Daniel Roderer7
2 more authors
  • Shanshuang Chen8
  • Adam Lange1,9
9 affiliations
  1. 1Research Unit Molecular Biophysics, Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany.
  2. 2Hefei National Research Center for Interdisciplinary Sciences at the Microscale, University of Science and Technology of China, Hefei, Anhui, China.
  3. 3Core Facility for Cryo–Electron Microscopy of the Charité—Universitätsmedizin Berlin at the Max Delbrück Center, Berlin, Germany.
  4. 4Max Delbrück Center for Molecular Medicine, Technology Platform Cryo-EM, Berlin, Germany.
  5. 5Research Unit Structural Chemistry and Computational Biophysics, Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany.
  6. 6Institute of Chemistry, Technische Universität Berlin, Berlin, Germany.
  7. 7Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany.
  8. 8Shanghai Institute of Precision Medicine, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  9. 9Institute of Biology, Humboldt-Universität zu Berlin, Berlin, Germany.
Open at sourceDOICite

Related

  1. The mechanosensitive channel TMEM63B contributes to noxious heat sensation in the dorsal root ganglia
    Chang Ye, Yan-Yu Zang, Gui-Fang Duan +8
    PLOS BiologyPeer-reviewedCC BY 4.0Full textBiophysicsCell biologyPLOSPMC
  2. Fold'EM: Direct atomic structure inference from Cryo-EM particles
    Advaith Maddipatla, Märt-Erik Mäeots, Marco Pegoraro +5
    arXivPreprintCC BY 4.0Full textBiophysicsarXiv
  3. Characterization of an open-channel structure and lateral conduction pathway in the cation-selective pentameric ligand-gated ion channel, ELIC
    Mark J Arcario, Elizabeth J Wu-Chen, Yuna Shim +3
    Journal of General PhysiologyPeer-reviewedCC BY 4.0Full textBiophysicsGeneral biologyHAL
  4. Molecular Dynamics-Guided Triage of Approved Drugs Against Escherichia coli Resistance Targets Nominates Capmatinib, Metergoline and Nilotinib as Candidates for Experimental Testing
    Mena Abdelsayed, Yassir Boulaamane
    International Journal of Molecular SciencesPeer-reviewedCC BY 4.0Full textGeneral biochemistryCrossrefEurope PMC
  5. DIELECTRIC CONTINUUM MODELING FOR THE DE NOVO DESIGNED CALCIUM CHANNEL CALC6.3: STRUCTURE PREPARATION, MESHGENERATION, AND CALCIUM SELECTIVITY
    R. S. Eisenberg, D. Xie
    bioRxivPreprintCC BYFull textBiophysicsbioRxiv

Cite

BibTeXRIS
BibTeX
@article{xiao2026atomic,
  title = {{Atomic structure and dynamics of the mechanosensitive channel MscL from Escherichia coli by cryo-EM and solid-state NMR}},
  author = {Taoran Xiao and Alexandra Kovinko and Chaowei Shi and Henry Sawczyc and Denis Qoraj and Carl Öster and Thiemo Sprink and Anton F. Ketzel and Sascha Lange and Spyridon Kosteletos and Han Sun and Daniel Roderer and Shanshuang Chen and Adam Lange},
  journal = {Science Advances},
  year = {2026},
  month = oct,
  doi = {10.1126/sciadv.aei0096},
  url = {https://www.science.org/doi/10.1126/sciadv.aei0096},
}
RIS
TY  - JOUR
TI  - Atomic structure and dynamics of the mechanosensitive channel MscL from Escherichia coli by cryo-EM and solid-state NMR
AU  - Taoran Xiao
AU  - Alexandra Kovinko
AU  - Chaowei Shi
AU  - Henry Sawczyc
AU  - Denis Qoraj
AU  - Carl Öster
AU  - Thiemo Sprink
AU  - Anton F. Ketzel
AU  - Sascha Lange
AU  - Spyridon Kosteletos
AU  - Han Sun
AU  - Daniel Roderer
AU  - Shanshuang Chen
AU  - Adam Lange
PY  - 2026
DA  - 2026/10/09
JO  - Science Advances
DO  - 10.1126/sciadv.aei0096
UR  - https://www.science.org/doi/10.1126/sciadv.aei0096
SN  - 2375-2548
ER  -