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Peer-reviewedCC BY 4.0Journal of the Society for Cardiovascular Angiography & Interventions

Trends and Disparities in Aortic Stenosis–Related Mortality Among Adults Aged ≥65 Years in the United States From 1999 to 2024

  • Aymen Ahmed1,2
  • Muteia Shakoor3
  • Usama Hussain Kamal4
  • Hiba Sohail3
  • Muhammad Hasnain Mankani5
  • Vikash Jaiswal1,2
  • Najam Us Saqib1,2
  • Nso Nso1,2
  • Arman Qamar1,2
  • Mark J. Ricciardi1,2
5 affiliations
  1. 1Section of Interventional Cardiology, Endeavor Center for Cardiovascular Intervention Outcomes Research and Evaluation (ECCORE), Endeavor Health Cardiovascular Institute, Glenview, Illinois
  2. 2The University of Chicago Pritzker School of Medicine, Chicago, Illinois
  3. 3Department of Medicine, Dow University of Health Sciences, Karachi, Pakistan
  4. 4Department of Medicine, Services Institute of Medical Sciences, Lahore, Pakistan
  5. 5Department of Medicine, Aga Khan University Hospital, Karachi, Pakistan
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Abstract

Background: Aortic stenosis (AS) remains a leading cause of cardiovascular death, yet temporal mortality trends specifically among older adults remain poorly characterized. This study analyzed trends and disparities in AS-related mortality among older adults in the United States from 1999 to 2024.

Methods: Using the CDC WONDER database, we analyzed AS-related deaths among adults aged ≥65 years. Age-adjusted mortality rates (AAMR) and average annual percent change (AAPC) were calculated across demographic and geographic subgroups.

Results: A total of 637,178 deaths were recorded. The overall AAMR for AS-related mortality decreased significantly from 1999 (55.74) to 2024 (52.46) (AAPC, –0.23; P =.004). Although rates rose from 2018 to 2021, a significant decline followed through 2024 (annual percent change, –2.40). Men had consistently higher AAMR than women; mortality remained stable in men (AAPC, –0.06; P = .33), but declined among women (AAPC, –0.35; P =.002). AS-related mortality decreased among patients aged 75 to 84 years, but increased in those ≥85 years (AAPC, 0.28), who had the highest AAMR throughout. Mortality declined in all census regions except for the Midwest, reaching the highest AAMR in 2024 (60.91). Nonmetropolitan areas saw increasing trends, whereas metropolitan areas saw declines. AAMR remained highest among non-Hispanic (NH) White individuals; however, significant decreases were observed in Hispanic/Latino and NH Asian/Pacific Islander populations.

Conclusions: Aortic stenosis–related mortality declined modestly among older adults from 1999 to 2024. However, notable demographic and regional disparities persisted, including higher mortality in men, NH White individuals, older adults ≥85 years, and residents of nonmetropolitan regions and the Midwest. Further investigation and targeted interventions are needed to improve outcomes.

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Cite

BibTeXRIS
BibTeX
@article{ahmed2026trends,
  title = {{Trends and Disparities in Aortic Stenosis–Related Mortality Among Adults Aged ≥65 Years in the United States From 1999 to 2024}},
  author = {Aymen Ahmed and Muteia Shakoor and Usama Hussain Kamal and Hiba Sohail and Muhammad Hasnain Mankani and Vikash Jaiswal and Najam Us Saqib and Nso Nso and Arman Qamar and Mark J. Ricciardi},
  journal = {Journal of the Society for Cardiovascular Angiography \& Interventions},
  year = {2026},
  month = aug,
  doi = {10.1016/j.jscai.2026.105573},
  url = {https://doi.org/10.1016/j.jscai.2026.105573},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Trends and Disparities in Aortic Stenosis–Related Mortality Among Adults Aged ≥65 Years in the United States From 1999 to 2024
AU  - Aymen Ahmed
AU  - Muteia Shakoor
AU  - Usama Hussain Kamal
AU  - Hiba Sohail
AU  - Muhammad Hasnain Mankani
AU  - Vikash Jaiswal
AU  - Najam Us Saqib
AU  - Nso Nso
AU  - Arman Qamar
AU  - Mark J. Ricciardi
PY  - 2026
DA  - 2026/08/11
JO  - Journal of the Society for Cardiovascular Angiography & Interventions
DO  - 10.1016/j.jscai.2026.105573
UR  - https://doi.org/10.1016/j.jscai.2026.105573
AB  - Background: Aortic stenosis (AS) remains a leading cause of cardiovascular death, yet temporal mortality trends specifically among older adults remain poorly characterized. This study analyzed trends and disparities in AS-related mortality among older adults in the United States from 1999 to 2024.  Methods: Using the CDC WONDER database, we analyzed AS-related deaths among adults aged ≥65 years. Age-adjusted mortality rates (AAMR) and average annual percent change (AAPC) were calculated across demographic and geographic subgroups.  Results: A total of 637,178 deaths were recorded. The overall AAMR for AS-related mortality decreased significantly from 1999 (55.74) to 2024 (52.46) (AAPC, –0.23; P =.004). Although rates rose from 2018 to 2021, a significant decline followed through 2024 (annual percent change, –2.40). Men had consistently higher AAMR than women; mortality remained stable in men (AAPC, –0.06; P = .33), but declined among women (AAPC, –0.35; P =.002). AS-related mortality decreased among patients aged 75 to 84 years, but increased in those ≥85 years (AAPC, 0.28), who had the highest AAMR throughout. Mortality declined in all census regions except for the Midwest, reaching the highest AAMR in 2024 (60.91). Nonmetropolitan areas saw increasing trends, whereas metropolitan areas saw declines. AAMR remained highest among non-Hispanic (NH) White individuals; however, significant decreases were observed in Hispanic/Latino and NH Asian/Pacific Islander populations.  Conclusions: Aortic stenosis–related mortality declined modestly among older adults from 1999 to 2024. However, notable demographic and regional disparities persisted, including higher mortality in men, NH White individuals, older adults ≥85 years, and residents of nonmetropolitan regions and the Midwest. Further investigation and targeted interventions are needed to improve outcomes.
SN  - 2772-9303
ER  -