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Peer-reviewedCC BYAntibodies (Basel, Switzerland)

Antibody Discovery and Therapeutics in Spondyloarthritis: Recent Advances and Future Directions.

  • Kwai Wei Chan1
  • Ghee Chong Koo2
  • Che Kang Lim1,3
  1. 1Department of Clinical Translational Research, Singapore General Hospital, Outram Rd, Singapore 169608, Singapore.
  2. 2School of Biomedical Science and Pharmacy, Newcastle Australia Institute of Higher Education, 100 Victoria St, #13-01/02, Singapore 188064, Singapore.
  3. 3Medicine Academic Clinical Programme, Duke-NUS Medical School, 8 College Rd, Singapore 169857, Singapore.
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Abstract

Spondyloarthritis is a multi-faceted condition housing a group of inter-related chronic inflammatory rheumatic diseases such as ankylosing spondylitis, IBD-associated arthritis, psoriatic arthritis and juvenile idiopathic arthritis. While decades of research and technological advancements have significantly improved our understanding of the disease, there remain many underlying genetic and physiological mechanisms which are unsolved but essential for the development of the right diagnosis and treatment. This mini-review examines our current foundational knowledge of spondyloarthritis, the main concepts related to the disease pathogenesis and the various lines of therapies developed thus far. We hope to provide a perspective on the current and potential antibody discovery platforms for the next decade as computational methods and artificial intelligence become increasingly mature and relevant in clinical research.

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Cite

BibTeXRIS
BibTeX
@article{chan2026antibody,
  title = {{Antibody Discovery and Therapeutics in Spondyloarthritis: Recent Advances and Future Directions.}},
  author = {Kwai Wei Chan and Ghee Chong Koo and Che Kang Lim},
  journal = {Antibodies (Basel, Switzerland)},
  year = {2026},
  month = oct,
  doi = {10.3390/antib15050090},
  url = {https://europepmc.org/article/MED/42930032},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Antibody Discovery and Therapeutics in Spondyloarthritis: Recent Advances and Future Directions.
AU  - Kwai Wei Chan
AU  - Ghee Chong Koo
AU  - Che Kang Lim
PY  - 2026
DA  - 2026/10/05
JO  - Antibodies (Basel, Switzerland)
DO  - 10.3390/antib15050090
UR  - https://europepmc.org/article/MED/42930032
AB  - Spondyloarthritis is a multi-faceted condition housing a group of inter-related chronic inflammatory rheumatic diseases such as ankylosing spondylitis, IBD-associated arthritis, psoriatic arthritis and juvenile idiopathic arthritis. While decades of research and technological advancements have significantly improved our understanding of the disease, there remain many underlying genetic and physiological mechanisms which are unsolved but essential for the development of the right diagnosis and treatment. This mini-review examines our current foundational knowledge of spondyloarthritis, the main concepts related to the disease pathogenesis and the various lines of therapies developed thus far. We hope to provide a perspective on the current and potential antibody discovery platforms for the next decade as computational methods and artificial intelligence become increasingly mature and relevant in clinical research.
SN  - 2073-4468
ER  -