Acute kidney disease following cisplatin treatment in head and neck cancer: risk factors and survival impact.
5 affiliations
- 1Department of Otorhinolaryngology-Head and Neck Surgery, China Medical University Hospital, Taichung, Taiwan.
- 2School of Medicine, China Medical University, Taichung, Taiwan.
- 3Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.
- 4Department of Otorhinolaryngology-Head and Neck Surgery, Asia University Hospital, Taichung, Taiwan.
- 5Center for Molecular Medicine, China Medical University Hospital, Taichung, Taiwan.
Abstract
Acute kidney disease (AKD), representing persistent or subacute kidney dysfunction occurring within 7 to 90 days, has emerged as an important framework bridging acute kidney injury (AKI) and chronic kidney disease. However, the occurrence and long-term clinical implications of AKD following cisplatin treatment in patients with head and neck squamous cell carcinoma (HNSCC) remain incompletely characterized. This study retrospectively analyzed patients with HNSCC treated with cisplatin using a longitudinal institutional clinical database. AKD was classified using the prespecified renal-function criteria applied in the original data-extraction algorithm during the 7-90-day period following cisplatin treatment. Clinical characteristics, AKD occurrence, and 5-year all-cause mortality were evaluated. Among the 2,033 patients, AKD occurred in 575 (28.3%) patients. Diabetes mellitus was more prevalent among patients with AKD than among those without AKD (20.0% vs. 12.3%, p < 0.001) in univariable analysis. In the prespecified Cox model, the association between AKD and 5-year all-cause mortality did not reach statistical significance (adjusted HR, 1.09; 95% CI, 0.94-1.25). Only two ESKD events were observed during follow-up (0.1%). AKD was observed in 28.3% of this historical cohort of patients with HNSCC treated with cisplatin. Diabetes mellitus was more prevalent among patients with AKD in univariable analysis. The association between AKD and 5-year all-cause mortality did not reach statistical significance in the prespecified adjusted model, although the confidence interval did not exclude a clinically meaningful increase in risk.
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BibTeX
@article{hung2026acute,
title = {{Acute kidney disease following cisplatin treatment in head and neck cancer: risk factors and survival impact.}},
author = {Yu-Hsiang Hung and Chieh-Ting Chen and Yung-An Tsou and Wei-Chao Chang and Chien-Jen Chiu},
journal = {Frontiers in medicine},
year = {2026},
month = oct,
doi = {10.3389/fmed.2026.1927784},
url = {https://europepmc.org/article/MED/42953184},
note = {CC BY},
}
RIS
TY - JOUR
TI - Acute kidney disease following cisplatin treatment in head and neck cancer: risk factors and survival impact.
AU - Yu-Hsiang Hung
AU - Chieh-Ting Chen
AU - Yung-An Tsou
AU - Wei-Chao Chang
AU - Chien-Jen Chiu
PY - 2026
DA - 2026/10/14
JO - Frontiers in medicine
DO - 10.3389/fmed.2026.1927784
UR - https://europepmc.org/article/MED/42953184
AB - Acute kidney disease (AKD), representing persistent or subacute kidney dysfunction occurring within 7 to 90 days, has emerged as an important framework bridging acute kidney injury (AKI) and chronic kidney disease. However, the occurrence and long-term clinical implications of AKD following cisplatin treatment in patients with head and neck squamous cell carcinoma (HNSCC) remain incompletely characterized. This study retrospectively analyzed patients with HNSCC treated with cisplatin using a longitudinal institutional clinical database. AKD was classified using the prespecified renal-function criteria applied in the original data-extraction algorithm during the 7-90-day period following cisplatin treatment. Clinical characteristics, AKD occurrence, and 5-year all-cause mortality were evaluated. Among the 2,033 patients, AKD occurred in 575 (28.3%) patients. Diabetes mellitus was more prevalent among patients with AKD than among those without AKD (20.0% vs. 12.3%, p < 0.001) in univariable analysis. In the prespecified Cox model, the association between AKD and 5-year all-cause mortality did not reach statistical significance (adjusted HR, 1.09; 95% CI, 0.94-1.25). Only two ESKD events were observed during follow-up (0.1%). AKD was observed in 28.3% of this historical cohort of patients with HNSCC treated with cisplatin. Diabetes mellitus was more prevalent among patients with AKD in univariable analysis. The association between AKD and 5-year all-cause mortality did not reach statistical significance in the prespecified adjusted model, although the confidence interval did not exclude a clinically meaningful increase in risk.
SN - 2296-858X
ER -