Embolic Ischemic Stroke Associated with Maintenance Intravenous Immunoglobulin Therapy
Abstract
We describe the case of a 51-year-old man who experienced an embolic ischemic stroke during long-term maintenance of intravenous immunoglobulin (IVIG) therapy for chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). At 43 years of age, he was diagnosed with CIDP and had tolerated IVIG well. Immediately after completing the 112th infusion, he exhibited acute right-hand clumsiness. Brain magnetic resonance imaging revealed an acute embolic infarction, and neither risk factors for ischemic stroke nor alternative embolic sources were identified. Although IVIG is generally considered safe, this case highlights that embolic stroke may occur even in relatively younger, low-risk patients during uneventful maintenance IVIG therapy, warranting continued vigilance.
Related
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- Hyaluronidase-Facilitated Subcutaneous Immunoglobulin 10% as Maintenance Therapy for Japanese Patients with Chronic Inflammatory Demyelinating Polyradiculoneuropathy and Multifocal Motor Neuropathy: A Phase 3, Open-label Clinical Trial
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BibTeX
@article{miyano2026embolic,
title = {{Embolic Ischemic Stroke Associated with Maintenance Intravenous Immunoglobulin Therapy}},
author = {Ryoji Miyano and Yu Yoshida and Kazuki Fujita and Yuka Hayashi and Yoshio Sakiyama},
journal = {Internal Medicine},
year = {2026},
month = oct,
doi = {10.2169/internalmedicine.6976-25},
url = {https://www.jstage.jst.go.jp/article/internalmedicine/65/20/65_6976-25/_article},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Embolic Ischemic Stroke Associated with Maintenance Intravenous Immunoglobulin Therapy
AU - Ryoji Miyano
AU - Yu Yoshida
AU - Kazuki Fujita
AU - Yuka Hayashi
AU - Yoshio Sakiyama
PY - 2026
DA - 2026/10/15
JO - Internal Medicine
DO - 10.2169/internalmedicine.6976-25
UR - https://www.jstage.jst.go.jp/article/internalmedicine/65/20/65_6976-25/_article
AB - We describe the case of a 51-year-old man who experienced an embolic ischemic stroke during long-term maintenance of intravenous immunoglobulin (IVIG) therapy for chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). At 43 years of age, he was diagnosed with CIDP and had tolerated IVIG well. Immediately after completing the 112th infusion, he exhibited acute right-hand clumsiness. Brain magnetic resonance imaging revealed an acute embolic infarction, and neither risk factors for ischemic stroke nor alternative embolic sources were identified. Although IVIG is generally considered safe, this case highlights that embolic stroke may occur even in relatively younger, low-risk patients during uneventful maintenance IVIG therapy, warranting continued vigilance.
SN - 1349-7235
SN - 0918-2918
ER -