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Peer-reviewedCC BY-NC-NDJournal of family medicine and primary care

Intracranial hemorrhage in a patient with Guillain–Barré syndrome following intravenous immunoglobulin therapy: A rare complication

  • Preeti Singh Dhoat1
  • Amandeep Kaur1
  • Rohit Raina1
  • Navdeep Kaur2
  • Sonali Mina1
  1. 1Department of General Medicine, AIIMS, Bathinda, Punjab, India
  2. 2Department of Radiology, AIIMS, Bathinda, Punjab, India
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Abstract

Guillain–Barré syndrome (GBS) is an acute immune-mediated polyradiculoneuropathy characterized by progressive weakness, areflexia, and variable autonomic dysfunction. Intracranial hemorrhage (ICH) is an extremely uncommon neurological complication associated with GBS and has been rarely described in the literature. We report a case of a 53-year-old female who presented with rapidly progressive quadriparesis and respiratory failure. Clinical findings and nerve conduction studies were suggestive of pure motor axonal GBS. The patient was treated with intravenous immunoglobulin (IVIG) at a dose of 0.4 g/kg/day for five days. During treatment, she developed sudden deterioration in sensorium, and computed tomography of the brain revealed pontine hemorrhage with perilesional edema. Platelet count and coagulation parameters remained within normal limits. Despite intensive supportive management, the patient developed cardiac arrest and could not be revived. Intracranial hemorrhage is a rare but potentially fatal complication in patients with GBS. Sudden neurological deterioration during the course of disease or IVIG therapy should prompt immediate neuroimaging evaluation.

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Cite

BibTeXRIS
BibTeX
@article{dhoat2026intracranial,
  title = {{Intracranial hemorrhage in a patient with Guillain–Barré syndrome following intravenous immunoglobulin therapy: A rare complication}},
  author = {Preeti Singh Dhoat and Amandeep Kaur and Rohit Raina and Navdeep Kaur and Sonali Mina},
  journal = {Journal of family medicine and primary care},
  year = {2026},
  month = jul,
  doi = {10.4103/jfmpc.jfmpc_441_25},
  url = {https://europepmc.org/article/PMC/PMC13722235},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Intracranial hemorrhage in a patient with Guillain–Barré syndrome following intravenous immunoglobulin therapy: A rare complication
AU  - Preeti Singh Dhoat
AU  - Amandeep Kaur
AU  - Rohit Raina
AU  - Navdeep Kaur
AU  - Sonali Mina
PY  - 2026
DA  - 2026/07/01
JO  - Journal of family medicine and primary care
DO  - 10.4103/jfmpc.jfmpc_441_25
UR  - https://europepmc.org/article/PMC/PMC13722235
AB  - Guillain–Barré syndrome (GBS) is an acute immune-mediated polyradiculoneuropathy characterized by progressive weakness, areflexia, and variable autonomic dysfunction. Intracranial hemorrhage (ICH) is an extremely uncommon neurological complication associated with GBS and has been rarely described in the literature. We report a case of a 53-year-old female who presented with rapidly progressive quadriparesis and respiratory failure. Clinical findings and nerve conduction studies were suggestive of pure motor axonal GBS. The patient was treated with intravenous immunoglobulin (IVIG) at a dose of 0.4 g/kg/day for five days. During treatment, she developed sudden deterioration in sensorium, and computed tomography of the brain revealed pontine hemorrhage with perilesional edema. Platelet count and coagulation parameters remained within normal limits. Despite intensive supportive management, the patient developed cardiac arrest and could not be revived. Intracranial hemorrhage is a rare but potentially fatal complication in patients with GBS. Sudden neurological deterioration during the course of disease or IVIG therapy should prompt immediate neuroimaging evaluation.
SN  - 2249-4863
SN  - 2278-7135
ER  -