Metabolomics-Guided Bioactivity Evaluation of Disease-Resistant Hybrid Grape Canes for Cosmetic Valorization
- 1Université de Tours , , 31 av . , ,
- 2Cracow University of Technology , , 24 Warszawska Street , ,
- 3Université d’Orléans-CNRS , , UMR 7311 BP 6759, CEDEX 2 , ,
Abstract
Grape canes constitute a valuable source of diverse polyphenols with recognized cosmetic properties, whose composition varies according to genotype and environmental conditions. Because grapevine resistance to pathogens is partly mediated by the biosynthesis of polyphenolic phytoalexins, disease-resistant Euro-American interspecific hybrids constitute particularly promising candidates for the sustainable sourcing of high-value natural cosmetic ingredients. Semitargeted UPLC-DAD-MS/MS analysis enabled the identification and quantification of 66 metabolites in grape cane extracts obtained from 24 interspecific hybrids and three Vitis vinifera cultivars as reference, cultivated over two consecutive years. Metabolomics coupled with unsupervised multivariate analysis was employed to characterize polyphenolic variability across the hybrid collection, revealing greater phytochemical diversity in Euro-American hybrids compared to European varieties. Antioxidant capacity was assessed using Oxygen Radical Antioxidant Capacity, ABTS, DPPH, ferric-reducing antioxidant power, CUPRAC, and metal chelation assays, alongside antityrosinase activity evaluation to determine skin-brightening potential. Pairwise correlation analyses between individual polyphenols and bioactivities were conducted to identify the compounds most strongly associated with antioxidant and antityrosinase effects in these complex botanical matrices. Overall, integrated metabolomic and bioactivity profiling highlights the strong potential of disease-resistant hybrid grape cane resources for cosmetic valorization.
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BibTeX
@article{ferrier2026metabolomicsguided,
title = {{Metabolomics-Guided Bioactivity Evaluation of Disease-Resistant Hybrid Grape Canes for Cosmetic Valorization}},
author = {Manon Ferrier and Cécile Abdallah and Magdalena Anna Malinowska and Laurine Garros and Marianne Unlubayir and Marin-Pierre Gémin and Nathalie Giglioli-Guivarc’h and Christophe Hano and Arnaud Lanoue},
journal = {ACS Omega},
year = {2026},
month = oct,
doi = {10.1021/acsomega.6c01924},
url = {https://pubs.acs.org/acsodf/article/11/42/64452/5451551/Metabolomics-Guided-Bioactivity-Evaluation-of},
note = {CC BY-NC-ND 4.0},
}
RIS
TY - JOUR
TI - Metabolomics-Guided Bioactivity Evaluation of Disease-Resistant Hybrid Grape Canes for Cosmetic Valorization
AU - Manon Ferrier
AU - Cécile Abdallah
AU - Magdalena Anna Malinowska
AU - Laurine Garros
AU - Marianne Unlubayir
AU - Marin-Pierre Gémin
AU - Nathalie Giglioli-Guivarc’h
AU - Christophe Hano
AU - Arnaud Lanoue
PY - 2026
DA - 2026/10/14
JO - ACS Omega
DO - 10.1021/acsomega.6c01924
UR - https://pubs.acs.org/acsodf/article/11/42/64452/5451551/Metabolomics-Guided-Bioactivity-Evaluation-of
AB - Grape canes constitute a valuable source of diverse polyphenols with recognized cosmetic properties, whose composition varies according to genotype and environmental conditions. Because grapevine resistance to pathogens is partly mediated by the biosynthesis of polyphenolic phytoalexins, disease-resistant Euro-American interspecific hybrids constitute particularly promising candidates for the sustainable sourcing of high-value natural cosmetic ingredients. Semitargeted UPLC-DAD-MS/MS analysis enabled the identification and quantification of 66 metabolites in grape cane extracts obtained from 24 interspecific hybrids and three Vitis vinifera cultivars as reference, cultivated over two consecutive years. Metabolomics coupled with unsupervised multivariate analysis was employed to characterize polyphenolic variability across the hybrid collection, revealing greater phytochemical diversity in Euro-American hybrids compared to European varieties. Antioxidant capacity was assessed using Oxygen Radical Antioxidant Capacity, ABTS, DPPH, ferric-reducing antioxidant power, CUPRAC, and metal chelation assays, alongside antityrosinase activity evaluation to determine skin-brightening potential. Pairwise correlation analyses between individual polyphenols and bioactivities were conducted to identify the compounds most strongly associated with antioxidant and antityrosinase effects in these complex botanical matrices. Overall, integrated metabolomic and bioactivity profiling highlights the strong potential of disease-resistant hybrid grape cane resources for cosmetic valorization.
SN - 2470-1343
ER -