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Peer-reviewedCC BYHereditas

LINC00907 suppresses malignant progression in hepatocellular carcinoma by inhibiting miR-24-3p.

  • Jihua Cao1
  • Weiyong Yang2
  • Xiao Yang3
  • Huayun Zhu4
4 affiliations
  1. 1Department of Hepatobiliary Surgery, The First College of Clinical Medical Science, China Three Gorges University, Yichang Central Peoples Hospital, Yichang, 443000, China.
  2. 2Oncology Department, Xinchang Hospital of Chinese Medicine, Shaoxing, 312500, China.
  3. 3Digestive Oncology Department, Changzhou Third Peoples Hospital, Changzhou, 213000, China.
  4. 4Departments of Medical Oncology, Jiangsu Cancer Hospital & Institute Affiliated to Nanjing Medical University, No.42, Baiziting Road, Nanjing, 210009, China. [email protected].
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Abstract

Objective

This study aimed to clarify the role of LINC00907 in hepatocellular carcinoma (HCC) and its underlying molecular mechanisms.Methods

The research population comprised 117 participants diagnosed with HCC. The expressions of LINC00907 and miR-24-3p in both tissue specimens and cell lines, along with those of EMT markers and the MMP-2 and MMP-9, were measured using RT-qPCR. Cellular proliferation was measured with the CCK-8 assay, while apoptotic rates were determined by flow cytometry. The direct interactions between LINC00907, miR-24-3p, and PDGFRL were validated by dual luciferase reporter and RNA pull-down assays. HCC cells were transfected with constructs specifically modulating LINC00907 and miR-24-3p to investigate the impact of their expression on malignant phenotypic behaviors.Results

LINC00907 expression was significantly downregulated in HCC, whereas miR-24-3p expression was upregulated. Low LINC00907 expression was linked to significantly worse overall survival, as determined by Kaplan-Meier analysis. The upregulation of LINC00907 led to the suppression of cell proliferation and EMT, while inducing apoptosis and reducing the levels of MMP-2 and MMP-9. LINC00907 was shown to directly target and negatively regulate miR-24-3p. Furthermore, rescue experiments demonstrated that upregulation of miR-24-3p counteracted the tumor-suppressive effects mediated by LINC00907 overexpression in HCC cells.Conclusion

LINC00907 exerts tumor-suppressive effects by targeting and negatively regulating miR-24-3p, thereby influencing proliferation, apoptosis, and EMT in HCC cells.

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Cite

BibTeXRIS
BibTeX
@article{cao2026linc00907,
  title = {{LINC00907 suppresses malignant progression in hepatocellular carcinoma by inhibiting miR-24-3p.}},
  author = {Jihua Cao and Weiyong Yang and Xiao Yang and Huayun Zhu},
  journal = {Hereditas},
  year = {2026},
  month = jul,
  doi = {10.1186/s41065-026-00714-6},
  url = {https://europepmc.org/article/MED/42907945},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - LINC00907 suppresses malignant progression in hepatocellular carcinoma by inhibiting miR-24-3p.
AU  - Jihua Cao
AU  - Weiyong Yang
AU  - Xiao Yang
AU  - Huayun Zhu
PY  - 2026
DA  - 2026/07/01
JO  - Hereditas
DO  - 10.1186/s41065-026-00714-6
UR  - https://europepmc.org/article/MED/42907945
AB  - Objective  This study aimed to clarify the role of LINC00907 in hepatocellular carcinoma (HCC) and its underlying molecular mechanisms.Methods  The research population comprised 117 participants diagnosed with HCC. The expressions of LINC00907 and miR-24-3p in both tissue specimens and cell lines, along with those of EMT markers and the MMP-2 and MMP-9, were measured using RT-qPCR. Cellular proliferation was measured with the CCK-8 assay, while apoptotic rates were determined by flow cytometry. The direct interactions between LINC00907, miR-24-3p, and PDGFRL were validated by dual luciferase reporter and RNA pull-down assays. HCC cells were transfected with constructs specifically modulating LINC00907 and miR-24-3p to investigate the impact of their expression on malignant phenotypic behaviors.Results  LINC00907 expression was significantly downregulated in HCC, whereas miR-24-3p expression was upregulated. Low LINC00907 expression was linked to significantly worse overall survival, as determined by Kaplan-Meier analysis. The upregulation of LINC00907 led to the suppression of cell proliferation and EMT, while inducing apoptosis and reducing the levels of MMP-2 and MMP-9. LINC00907 was shown to directly target and negatively regulate miR-24-3p. Furthermore, rescue experiments demonstrated that upregulation of miR-24-3p counteracted the tumor-suppressive effects mediated by LINC00907 overexpression in HCC cells.Conclusion  LINC00907 exerts tumor-suppressive effects by targeting and negatively regulating miR-24-3p, thereby influencing proliferation, apoptosis, and EMT in HCC cells.
SN  - 0018-0661
SN  - 1601-5223
ER  -