Peer-reviewedCC BY 4.0Chemistry (Weinheim an Der Bergstrasse, Germany)
Rhodium‐Catalyzed Synthesis of Enantioenriched α‐Substituted Primary Amines Through Asymmetric Transfer Hydrogenation
- 1Institute of Chemistry for Life and Health Sciences CNRS, CSB2D Team Paris France
- 2Faculty of Pharmaceutical Sciences Shenzhen University of Advanced Technology Shenzhen Guangdong China
Abstract
The preparation of a series of enantioenriched α‐substituted primary amines using rhodium‐catalyzed asymmetric transfer hydrogenation of ortho‐hydroxyaryl N─H imines is reported. The reaction proceeds under mild conditions using a low catalyst loading and ammonium formate as the hydrogen source, delivering the reduced compounds in high yields (up to 99%) and enantioselectivities (up to 99% ee).
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BibTeX
@article{liu2026rhodiumcatalyzed,
title = {{Rhodium‐Catalyzed Synthesis of Enantioenriched α‐Substituted Primary Amines Through Asymmetric Transfer Hydrogenation}},
author = {Chonghuo Liu and Guillaume Lefèvre and Qin Yin and Phannarath Phansavath and Virginie Ratovelomanana‐Vidal},
journal = {Chemistry (Weinheim an Der Bergstrasse, Germany)},
year = {2026},
month = jul,
doi = {10.1002/chem.71466},
url = {https://doi.org/10.1002/chem.71466},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Rhodium‐Catalyzed Synthesis of Enantioenriched α‐Substituted Primary Amines Through Asymmetric Transfer Hydrogenation
AU - Chonghuo Liu
AU - Guillaume Lefèvre
AU - Qin Yin
AU - Phannarath Phansavath
AU - Virginie Ratovelomanana‐Vidal
PY - 2026
DA - 2026/07/24
JO - Chemistry (Weinheim an Der Bergstrasse, Germany)
DO - 10.1002/chem.71466
UR - https://doi.org/10.1002/chem.71466
AB - The preparation of a series of enantioenriched α‐substituted primary amines using rhodium‐catalyzed asymmetric transfer hydrogenation of ortho‐hydroxyaryl N─H imines is reported. The reaction proceeds under mild conditions using a low catalyst loading and ammonium formate as the hydrogen source, delivering the reduced compounds in high yields (up to 99%) and enantioselectivities (up to 99% ee).
SN - 0947-6539
SN - 1521-3765
ER -