Peer-reviewedCC BY 4.0Chemistry - A European Journal
Ru‐Catalyzed Asymmetric Transfer Hydrogenation of α‐iminophosphonates: A Novel Synthetic Approach for Valuable Chiral α‐Aminophosphonates
Abstract
A novel Ru‐catalyzed asymmetric transfer hydrogenation (ATH) strategy has been developed for the efficient synthesis of valuable chiral α ‐aminophosphonates from readily available α ‐iminophosphonates. This method enables the conversion of both acyclic and cyclic substrates in high yields (up to 97%) and excellent enantioselectivities (up to >99:1), providing a practical entry to phosphorus‐containing chiral amines. Notably, this is the first reported application of ATH to α ‐iminophosphonates, offering a robust and operationally convenient alternative to conventional asymmetric hydrogenation (AH) approaches.
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BibTeX
@article{plouard2026rucatalyzed,
title = {{Ru‐Catalyzed Asymmetric Transfer Hydrogenation of α‐iminophosphonates: A Novel Synthetic Approach for Valuable Chiral α‐Aminophosphonates}},
author = {Pierre Plouard and Laura Borrel and Pierre-Olivier Butin and Paul Muller and Rémi Cherpitel and Séverine Loiseau and Ludovic Clarion and David Virieux and Tahar Ayad},
journal = {Chemistry - A European Journal},
year = {2026},
month = sep,
doi = {10.1002/chem.202502405},
url = {https://hal.science/hal-05736156v1},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Ru‐Catalyzed Asymmetric Transfer Hydrogenation of α‐iminophosphonates: A Novel Synthetic Approach for Valuable Chiral α‐Aminophosphonates
AU - Pierre Plouard
AU - Laura Borrel
AU - Pierre-Olivier Butin
AU - Paul Muller
AU - Rémi Cherpitel
AU - Séverine Loiseau
AU - Ludovic Clarion
AU - David Virieux
AU - Tahar Ayad
PY - 2026
DA - 2026/09/02
JO - Chemistry - A European Journal
DO - 10.1002/chem.202502405
UR - https://hal.science/hal-05736156v1
AB - A novel Ru‐catalyzed asymmetric transfer hydrogenation (ATH) strategy has been developed for the efficient synthesis of valuable chiral α ‐aminophosphonates from readily available α ‐iminophosphonates. This method enables the conversion of both acyclic and cyclic substrates in high yields (up to 97%) and excellent enantioselectivities (up to >99:1), providing a practical entry to phosphorus‐containing chiral amines. Notably, this is the first reported application of ATH to α ‐iminophosphonates, offering a robust and operationally convenient alternative to conventional asymmetric hydrogenation (AH) approaches.
SN - 0947-6539
SN - 1521-3765
ER -