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PreprintCC BY-NC-NDChemRxiv

Atom-precise nanocluster architectures programmed by biomolecular assembly

  • Nandini Kundu1,2
  • Eshana Bethur1,2
  • Anna Gonzàlez-Rosell1,2
  • Anthea Segger1,2
  • Kylie Lytle1,2
  • Rweetuparna Guha1,2
  • Stacy M. Copp1,2,3,4,5
5 affiliations
  1. 1Department of Materials Science and Engineering
  2. 2University of California
  3. 3Department of Chemistry
  4. 4Department of Physics and Astronomy
  5. 5Department of Chemical and Biomolecular Engineering
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Abstract

Ligand-protected metal nanoclusters hold promise as atomically precise building blocks for nanoscale materials. However, it remains challenging to achieve ligand chemistries that control higher-order organization while still retaining the nanocluster’s atom-precise properties. Here, we present two biomolecular approaches for higher-order organization of silver nanoclusters stabilized by DNA (DNA-Ag N ). First, using strategies from DNA nanotechnology, we develop complementary DNA-Ag N that oligomerize upon toehold-mediated strand displacement reactions. Second, we exploit biotin-streptavidin interactions to oligomerize biotinylated DNA-Ag N . Higherorder assembly is confirmed by native polyacrylamide gel electrophoresis and cryo-electron microscopy. Optical spectroscopy shows that the nanoclusters retain their optical properties upon assembly, supporting the integrity of their atomically precise structures during biomolecular organization. These results demonstrate the utility of programmable biomolecular interactions for the higher-order assembly of atom-precise inorganic nanoclusters.

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Cite

BibTeXRIS
BibTeX
@misc{kundu2026atomprecise,
  title = {{Atom-precise nanocluster architectures programmed by biomolecular assembly}},
  author = {Nandini Kundu and Eshana Bethur and Anna Gonzàlez-Rosell and Anthea Segger and Kylie Lytle and Rweetuparna Guha and Stacy M. Copp},
  howpublished = {ChemRxiv},
  year = {2026},
  month = oct,
  doi = {10.26434/chemrxiv.15010775/v1},
  url = {https://chemrxiv.org/doi/full/10.26434/chemrxiv.15010775/v1},
  note = {CC BY-NC-ND},
}
RIS
TY  - UNPB
TI  - Atom-precise nanocluster architectures programmed by biomolecular assembly
AU  - Nandini Kundu
AU  - Eshana Bethur
AU  - Anna Gonzàlez-Rosell
AU  - Anthea Segger
AU  - Kylie Lytle
AU  - Rweetuparna Guha
AU  - Stacy M. Copp
PY  - 2026
DA  - 2026/10/21
PB  - ChemRxiv
DO  - 10.26434/chemrxiv.15010775/v1
UR  - https://chemrxiv.org/doi/full/10.26434/chemrxiv.15010775/v1
AB  - Ligand-protected metal nanoclusters hold promise as atomically precise building blocks for nanoscale materials. However, it remains challenging to achieve ligand chemistries that control higher-order organization while still retaining the nanocluster’s atom-precise properties. Here, we present two biomolecular approaches for higher-order organization of silver nanoclusters stabilized by DNA (DNA-Ag N ). First, using strategies from DNA nanotechnology, we develop complementary DNA-Ag N that oligomerize upon toehold-mediated strand displacement reactions. Second, we exploit biotin-streptavidin interactions to oligomerize biotinylated DNA-Ag N . Higherorder assembly is confirmed by native polyacrylamide gel electrophoresis and cryo-electron microscopy. Optical spectroscopy shows that the nanoclusters retain their optical properties upon assembly, supporting the integrity of their atomically precise structures during biomolecular organization. These results demonstrate the utility of programmable biomolecular interactions for the higher-order assembly of atom-precise inorganic nanoclusters.
ER  -