Skip to content
DraconiticResearch
Search Sources API
197,768 studies31 sourcesUpdated 56 min ago
Peer-reviewedCC BY 4.0Frontiers in Endocrinology

Interconnected metabolic and reproductive signaling axis in type 2 diabetes mellitus and polyendocrine metabolic ovarian syndrome

  • Khurshid Ahmad Padder1,2
  • Mohd Ashraf Ganie1
  • Nusrat Jahan1,3
  • Mohmad Aadil Yousuf1
  • Tajali Sehar1,2
  • Mudasir Ahmad Bhat2
  • Showkat Hussain4
  • Saba Muzaffar2
  • Sadiq Majeed2
  • Refaz Ahmad Dar2
  • Touseef Sheikh5
5 affiliations
  1. 1Department of Endocrinology, Sher-i- Kashmir Institute of Medical Sciences
  2. 2Department of Biotechnology, Government Degree College (GDC) (Women)
  3. 3Department of Life Sciences, Jaipur National University, Jaipur
  4. 4Department of Allied and HealthCare, Guru Kashi University, Talwandi Sabo
  5. 5Department of Clinical Biochemistry, Government Degree College (GDC) (Women)
Open at sourcePDFDOICite

Abstract

Polyendocrine metabolic ovarian syndrome (PMOS) and type 2 diabetes milletus (T2DM) are interlinked endocrine and metabolic disorders characterized by insulin resistance (IR), hyperinsulinemia and chronic low-grade inflammation. Both these abnormal physiological and metabolic conditions share overlapping cellular and molecular pathways involving insulin signaling, PI3K/Akt dysregulation, oxidative stress (OS) and inflammatory cascades. In PMOS, these disturbances further intersect with reproductive axis dysfunction including hyperandrogenism and follicular arrest. This manuscript reviews the shared metabolic and reproductive signaling pathways in PMOS and T2DM, highlighting insulin signaling defects, AMPK–mTOR imbalance, WNT/β-catenin dysregulation and inflammatory mediators. Understanding these common pathways may facilitate development of unified and more specific therapeutic strategies targeting both metabolic and reproductive dysfunction among these disorders.

Related

  1. Aerobic and Aerobic-Oriented Exercise for Anthropometric, Androgen-Related, and Reproductive Endocrine Outcomes in Polyendocrine Metabolic Ovarian Syndrome (Polycystic Ovary Syndrome): A Systematic Review and Meta-Analysis
    Lanxin Qiu, Yunzhi Emma Huang, Mingnan Zhuang +2
    MetabolitesPeer-reviewedCC BY 4.0Full textObstetrics, gynaecology & paediatricsCrossrefEurope PMC
  2. Microbial Dysbiosis, Infection, and Immunometabolic Signaling in Polyendocrine Metabolic Ovarian Syndrome (Formerly PCOS).
    Allyson Nevins, Nicholas Stansbury, Randal D Robinson +1
    Pathogens (Basel, Switzerland)Peer-reviewedCC BYFull textObstetrics, gynaecology & paediatricsEurope PMC
  3. Real‐World Metabolic Improvements in Women With and Without Polyendocrine Metabolic Syndrome via a Multidisciplinary Telehealth Care Platform
    Heather G. Huddleston, Rachel Blank, Nandita Sommers +4
    Endocrinology, diabetes & metabolismPeer-reviewedCC BYFull textEndocrinology & metabolismEurope PMC
  4. Polyendocrine metabolic ovarian syndrome in adolescents.
    Allison Furness, Sarah McQuillan
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadiennePeer-reviewedCC BY-NC-NDFull textObstetrics, gynaecology & paediatricsEurope PMC
  5. Polyendocrine metabolic ovarian syndrome: a new name to support better treatment.
    Ginevra Mills
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadiennePeer-reviewedCC BY-NC-NDFull textObstetrics, gynaecology & paediatricsEurope PMC

Cite

BibTeXRIS
BibTeX
@article{padder2026interconnected,
  title = {{Interconnected metabolic and reproductive signaling axis in type 2 diabetes mellitus and polyendocrine metabolic ovarian syndrome}},
  author = {Khurshid Ahmad Padder and Mohd Ashraf Ganie and Nusrat Jahan and Mohmad Aadil Yousuf and Tajali Sehar and Mudasir Ahmad Bhat and Showkat Hussain and Saba Muzaffar and Sadiq Majeed and Refaz Ahmad Dar and Touseef Sheikh},
  journal = {Frontiers in Endocrinology},
  year = {2026},
  month = oct,
  doi = {10.3389/fendo.2026.1996827},
  url = {https://www.frontiersin.org/articles/10.3389/fendo.2026.1996827/full},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Interconnected metabolic and reproductive signaling axis in type 2 diabetes mellitus and polyendocrine metabolic ovarian syndrome
AU  - Khurshid Ahmad Padder
AU  - Mohd Ashraf Ganie
AU  - Nusrat Jahan
AU  - Mohmad Aadil Yousuf
AU  - Tajali Sehar
AU  - Mudasir Ahmad Bhat
AU  - Showkat Hussain
AU  - Saba Muzaffar
AU  - Sadiq Majeed
AU  - Refaz Ahmad Dar
AU  - Touseef Sheikh
PY  - 2026
DA  - 2026/10/20
JO  - Frontiers in Endocrinology
DO  - 10.3389/fendo.2026.1996827
UR  - https://www.frontiersin.org/articles/10.3389/fendo.2026.1996827/full
AB  - Polyendocrine metabolic ovarian syndrome (PMOS) and type 2 diabetes milletus (T2DM) are interlinked endocrine and metabolic disorders characterized by insulin resistance (IR), hyperinsulinemia and chronic low-grade inflammation. Both these abnormal physiological and metabolic conditions share overlapping cellular and molecular pathways involving insulin signaling, PI3K/Akt dysregulation, oxidative stress (OS) and inflammatory cascades. In PMOS, these disturbances further intersect with reproductive axis dysfunction including hyperandrogenism and follicular arrest. This manuscript reviews the shared metabolic and reproductive signaling pathways in PMOS and T2DM, highlighting insulin signaling defects, AMPK–mTOR imbalance, WNT/β-catenin dysregulation and inflammatory mediators. Understanding these common pathways may facilitate development of unified and more specific therapeutic strategies targeting both metabolic and reproductive dysfunction among these disorders.
SN  - 1664-2392
ER  -