Evaluation of efficacy and safety of use of Codubix and Codubix S cranial implants
6 affiliations
- 1Department of Neurosurgery and Neuro Oncology, Medical University of Lodz N.Barlicki Univeristy Hospital No 1
- 2Medical University of Lublin - Independent Public Clinical Hospital No. 4 in Lublin
- 3The Nicolaus Copernicus University in Torun
- 4Independent engineering consultant
- 5Faculty of Textiles and Design, Institute of Architecture of Textiles, Lodz University of Technology
- 6Tricomed S.A.
Abstract
The Codubix implant—a polypropylene-polyester (PP/PEK) braid is characterized by high biological compatibility, mechanical strength, resistance to bending forces and infections. This material, with cranioplastic properties similar to the parameters of natural bone, ensures high safety of use, and due to its porosity promotes rapid tissue overgrowth. The aim of the retrospective analysis was to assess the efficacy and safety of using cranial vault prostheses made of this material. The study included 121 patients (93 men, 28 women) from four clinical centers. The participants were divided into two groups based on the type of implanted prosthesis and the implant fixation system. Intraoperative data and information collected during two follow-up visits and the final interview with the patients were analyzed. Both standard prostheses (45) and customized variants (76) were used for implantation. Bone sutures and titanium clamps were used for fixation. Both methods ensured a stable fixation of the prosthesis. In the studied patient population, prostheses were an effective and safe method of filling bone defects of the skull cap providing high comfort (79.3%) and good cosmetic effect (62.0%). The size of the defect did not affect the recovery time, patient comfort or occurrence of postoperative complications. The average surgery time for implanting the individually adapted prostheses was approximately 70 min, while for the standard prostheses the average time was approximately 104 min. The CranioFix titanium clamps were used more often than other fixation methods. The study also examined the relationship between the fixation system and the surgical time. The surgeries with clamps lasted an average of 31 min longer than the ones with bone sutures. The time of the procedure depends on many factors, including the complexity of the surgery or the medical case.
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BibTeX
@article{kasprzak2026evaluation,
title = {{Evaluation of efficacy and safety of use of Codubix and Codubix S cranial implants}},
author = {Piotr Kasprzak and Dariusz J. Jaskólski and Radosław Rola and Klaudia Kuś-Budzyńska and Paula Złakowska and Dariusz Szczepanek and Mateusz Szostak and Grzegorz Tomaszewski and Magdalena Tokarska and Kaja Jezierska and Witold Sujka},
journal = {Scientific Reports},
year = {2026},
month = jul,
doi = {10.1038/s41598-026-64592-8},
url = {https://doi.org/10.1038/s41598-026-64592-8},
note = {CC BY},
}
RIS
TY - JOUR
TI - Evaluation of efficacy and safety of use of Codubix and Codubix S cranial implants
AU - Piotr Kasprzak
AU - Dariusz J. Jaskólski
AU - Radosław Rola
AU - Klaudia Kuś-Budzyńska
AU - Paula Złakowska
AU - Dariusz Szczepanek
AU - Mateusz Szostak
AU - Grzegorz Tomaszewski
AU - Magdalena Tokarska
AU - Kaja Jezierska
AU - Witold Sujka
PY - 2026
DA - 2026/07/01
JO - Scientific Reports
DO - 10.1038/s41598-026-64592-8
UR - https://doi.org/10.1038/s41598-026-64592-8
AB - The Codubix implant—a polypropylene-polyester (PP/PEK) braid is characterized by high biological compatibility, mechanical strength, resistance to bending forces and infections. This material, with cranioplastic properties similar to the parameters of natural bone, ensures high safety of use, and due to its porosity promotes rapid tissue overgrowth. The aim of the retrospective analysis was to assess the efficacy and safety of using cranial vault prostheses made of this material. The study included 121 patients (93 men, 28 women) from four clinical centers. The participants were divided into two groups based on the type of implanted prosthesis and the implant fixation system. Intraoperative data and information collected during two follow-up visits and the final interview with the patients were analyzed. Both standard prostheses (45) and customized variants (76) were used for implantation. Bone sutures and titanium clamps were used for fixation. Both methods ensured a stable fixation of the prosthesis. In the studied patient population, prostheses were an effective and safe method of filling bone defects of the skull cap providing high comfort (79.3%) and good cosmetic effect (62.0%). The size of the defect did not affect the recovery time, patient comfort or occurrence of postoperative complications. The average surgery time for implanting the individually adapted prostheses was approximately 70 min, while for the standard prostheses the average time was approximately 104 min. The CranioFix titanium clamps were used more often than other fixation methods. The study also examined the relationship between the fixation system and the surgical time. The surgeries with clamps lasted an average of 31 min longer than the ones with bone sutures. The time of the procedure depends on many factors, including the complexity of the surgery or the medical case.
SN - 2045-2322
ER -