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Peer-reviewedCC BY 4.0Molecules

Mass Spectrometry Analysis of Low-Molecular-Weight Sulfur-Containing Metabolites from an Infusion of Scorodophloeus zenkeri Stem Barks

  • Ericka Lorleil Mayindza Ekaghba1,2
  • Simon Ollivier3
  • Hélène Lavanant3
  • Olivier Perruchon2
  • Isabelle Schmitz3
  • Carlos Afonso3
  • Line Edwige Mengome1
  • Corinne Loutelier-Bourhis3
  • Patrice Lerouge2
  1. 1Institut de Pharmacopée et Médecines Traditionnelles (IPHAMETRA), Centre National de la Recherche Scientifique et Technique (CENAREST), Libreville BP 12 141, Gabon
  2. 2Université de Rouen Normandie (UNIROUEN), Normandie Univ, GlycoMEV UR 4358, SFR Normandie Végétal FED 4277, Innovation Chimie Carnot, 76000 Rouen, France
  3. 3Université de Rouen Normandie, INSA Rouen Normandie, Université de Caen Normandie, ENSICAEN, CNRS, Institut CARMeN UMR 6064, 76000 Rouen, France
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Abstract

Scorodophloeus zenkeri is a tree endemic to Central Africa that gives off a garlic-like odour. Therefore, its bark, seeds and wood are commonly used as a condiment in traditional foods in Cameroon and Gabon. Moreover, the infusion of the stem bark of S. zenkeri is used in traditional medicine in Gabon as a laxative. In the present study, we report on the phytochemical analysis by both ultra-high-performance liquid chromatography-tandem mass spectrometry and Fourier-transform ion cyclotron resonance mass spectrometry of the infusion of S. zenkeri bark. We focused our investigation in negative ion mode on sulfinic, sulfonic, sulfinosulfanyl, thiosulfuric acid derivatives and organosulfur metabolites containing up to four sulfur atoms. Rules for the MS/MS fragmentation of these unusual molecules are proposed.

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Cite

BibTeXRIS
BibTeX
@article{ekaghba2026mass,
  title = {{Mass Spectrometry Analysis of Low-Molecular-Weight Sulfur-Containing Metabolites from an Infusion of Scorodophloeus zenkeri Stem Barks}},
  author = {Ericka Lorleil Mayindza Ekaghba and Simon Ollivier and Hélène Lavanant and Olivier Perruchon and Isabelle Schmitz and Carlos Afonso and Line Edwige Mengome and Corinne Loutelier-Bourhis and Patrice Lerouge},
  journal = {Molecules},
  year = {2026},
  month = nov,
  doi = {10.3390/molecules31214027},
  url = {https://www.mdpi.com/1420-3049/31/21/4027},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Mass Spectrometry Analysis of Low-Molecular-Weight Sulfur-Containing Metabolites from an Infusion of Scorodophloeus zenkeri Stem Barks
AU  - Ericka Lorleil Mayindza Ekaghba
AU  - Simon Ollivier
AU  - Hélène Lavanant
AU  - Olivier Perruchon
AU  - Isabelle Schmitz
AU  - Carlos Afonso
AU  - Line Edwige Mengome
AU  - Corinne Loutelier-Bourhis
AU  - Patrice Lerouge
PY  - 2026
DA  - 2026/11/09
JO  - Molecules
DO  - 10.3390/molecules31214027
UR  - https://www.mdpi.com/1420-3049/31/21/4027
AB  - Scorodophloeus zenkeri is a tree endemic to Central Africa that gives off a garlic-like odour. Therefore, its bark, seeds and wood are commonly used as a condiment in traditional foods in Cameroon and Gabon. Moreover, the infusion of the stem bark of S. zenkeri is used in traditional medicine in Gabon as a laxative. In the present study, we report on the phytochemical analysis by both ultra-high-performance liquid chromatography-tandem mass spectrometry and Fourier-transform ion cyclotron resonance mass spectrometry of the infusion of S. zenkeri bark. We focused our investigation in negative ion mode on sulfinic, sulfonic, sulfinosulfanyl, thiosulfuric acid derivatives and organosulfur metabolites containing up to four sulfur atoms. Rules for the MS/MS fragmentation of these unusual molecules are proposed.
SN  - 1420-3049
ER  -