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Peer-reviewedCC BY-NC-ND 4.0Experimental hematology

Mast cell-derived histamine negatively regulates hematopoiesis

  • Bailey R. Klein1
  • Julianne N.P. Smith1
  • Ramachandra Katabathula1
  • Ritisha Rashmil1
  • Sofia X. Wilhelm1
  • Rahul Chaudhary1
  • Karina Inacio Ladislau De Carvalho1
  • Zhenxiang Gao1
  • Brittany A. Cordova1
  • Eric E. Irons2
  • Benjamin Kovacic3
  • Shikha Parsai3
7 more authors
  • Vladimir Makarov3
  • Frederick Petroze1
  • Riya Tiwari1
  • Stanton L. Gerson1,2
  • Rong Xu1
  • Sanford D. Markowitz1,2
  • Amar B. Desai1
  1. 1Department of Medicine, Case Comprehensive Cancer Center Case Western Reserve University, Cleveland, OH
  2. 2University Hospitals Seidman Cancer Center, Cleveland, OH
  3. 3Cleveland Clinic Research, Cancer Sciences, Cleveland, OH
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Abstract

Mast cell-derived histamine restrains hematopoietic stem cell activity by shaping the bone marrow niche. Blocking histamine signaling with the United States Food and Drug Administration (FDA)-approved antihistamine cetirizine expands the stem and progenitor pool and accelerates hematopoietic recovery after transplant, pointing to a repurposable strategy for boosting blood regeneration in patients.

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Cite

BibTeXRIS
BibTeX
@article{klein2026mast,
  title = {{Mast cell-derived histamine negatively regulates hematopoiesis}},
  author = {Bailey R. Klein and Julianne N.P. Smith and Ramachandra Katabathula and Ritisha Rashmil and Sofia X. Wilhelm and Rahul Chaudhary and Karina Inacio Ladislau De Carvalho and Zhenxiang Gao and Brittany A. Cordova and Eric E. Irons and Benjamin Kovacic and Shikha Parsai and Vladimir Makarov and Frederick Petroze and Riya Tiwari and Stanton L. Gerson and Rong Xu and Sanford D. Markowitz and Amar B. Desai},
  journal = {Experimental hematology},
  year = {2026},
  month = sep,
  doi = {10.1016/j.exphem.2026.105893},
  url = {https://doi.org/10.1016/j.exphem.2026.105893},
  note = {CC BY-NC-ND 4.0},
}
RIS
TY  - JOUR
TI  - Mast cell-derived histamine negatively regulates hematopoiesis
AU  - Bailey R. Klein
AU  - Julianne N.P. Smith
AU  - Ramachandra Katabathula
AU  - Ritisha Rashmil
AU  - Sofia X. Wilhelm
AU  - Rahul Chaudhary
AU  - Karina Inacio Ladislau De Carvalho
AU  - Zhenxiang Gao
AU  - Brittany A. Cordova
AU  - Eric E. Irons
AU  - Benjamin Kovacic
AU  - Shikha Parsai
AU  - Vladimir Makarov
AU  - Frederick Petroze
AU  - Riya Tiwari
AU  - Stanton L. Gerson
AU  - Rong Xu
AU  - Sanford D. Markowitz
AU  - Amar B. Desai
PY  - 2026
DA  - 2026/09/03
JO  - Experimental hematology
DO  - 10.1016/j.exphem.2026.105893
UR  - https://doi.org/10.1016/j.exphem.2026.105893
AB  - Mast cell-derived histamine restrains hematopoietic stem cell activity by shaping the bone marrow niche. Blocking histamine signaling with the United States Food and Drug Administration (FDA)-approved antihistamine cetirizine expands the stem and progenitor pool and accelerates hematopoietic recovery after transplant, pointing to a repurposable strategy for boosting blood regeneration in patients.
SN  - 0301-472X
SN  - 1873-2399
ER  -