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Peer-reviewedCC BY-NCDermatology practical & conceptual

Interplay of Biological Treatment and Psychological Features in Patients with Psoriasis: A Real-Life Prospective Study.

  • Gaia Moretta1
  • Tonia Samela2
  • Alessia Provini3
  • Gianluca Pagnanelli1
  • Dario Graceffa4
  • Diego Orsini4
  • Viviana Lora4
  • Antonio Giovanni Richetta5
  • Annunziata Dattola5
  • Simone Amato5
  • Nicoletta Bernardini6
  • Paola Tribuzi7
12 more authors
  • Arianna Zangrilli8
  • Martina Vultaggio8
  • Luca Bianchi8
  • Giacomo Caldarola9
  • Eleonora De Luca9
  • Clara De Simone9
  • Domenico Giordano10
  • Cinzia Masini11
  • Mauro Bavetta11
  • Stefania Lechiancole12
  • Vincenzo Panasiti13
  • Damiano Abeni2
13 affiliations
  1. 1Clinical Dermatology Department, IDI-IRCCS, Rome, Italy.
  2. 2Clinical Epidemiology, Clinical Psychology Unit, IDI-IRCCS, Rome, Italy.
  3. 3Asl Roma 2, Ospedale Sandro Pertini, Rome, Italy.
  4. 4San Gallicano Dermatological Institute, IRCCS, Rome, Italy.
  5. 5Dermatology Unit, Department of Clinical Internal, Anesthesiological and Cardiovascular Science, University of La Sapienza, Rome, Italy.
  6. 6Dermatology Unit, Department of Medical-Surgical Sciences and Bio-Technologies, Sapienza University of Rome, Fiorini Hospital, Polo Pontino, Terracina, Italy.
  7. 7Dermatology Department, Ospedale di Belcolle, Viterbo, Italy.
  8. 8Dermatology Unit, System Medicine Department, University of Tor Vergata, Rome, Italy.
  9. 9Institute of Dermatology, Università Cattolica del Sacro Cuore, Rome, Italy; Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
  10. 10Dermatology Unit, Sant'Andrea Hospital University of Rome, Rome, Italy.
  11. 11Dermatology Department, Ospedale San Sebastiano, Frascati, Roma, Italy.
  12. 12Clinical Dermatology Department, IDI-IRCCS, Capranica, Italy.
  13. 13Department of Plastic, Reconstructive and Cosmetic Surgery, Dermatology Unit, Campus Bio-Medico, Rome, Italy.
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Abstract

Introduction

Emotional dysregulation (ED), common among patients with psoriasis, leads to psychopathology and impairs treatment adherence.Objective

This study examined the changes in prevalence of ED in patients and its effects on illness perception, mental health, and quality of life (QoL) during one year of treatment with risankizumab.Method

ED, illness perception, general health, and QoL were measured at baseline, and at four, 16, and 52 weeks posttreatment in 58 patients with psoriasis.Results

Higher ED was associated with greater psychological distress and poorer QoL. Patients with higher levels of ED reported greater psychological distress, worse QoL, and higher symptom-related distress throughout treatment as compared to those with lower ones. Although both groups improved in terms of illness perception and clinical severity outcomes, patients with high ED consistently experienced worse subjective outcomes.Conclusion

ED is frequent in psoriasis patients and negatively affects mental health and QoL, despite clinical improvements in skin symptoms. Targeted psychological interventions may be necessary for patients who exhibit higher levels of emotional dysregulation to ensure comprehensive care and better long-term outcomes.

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Cite

BibTeXRIS
BibTeX
@article{moretta2026interplay,
  title = {{Interplay of Biological Treatment and Psychological Features in Patients with Psoriasis: A Real-Life Prospective Study.}},
  author = {Gaia Moretta and Tonia Samela and Alessia Provini and Gianluca Pagnanelli and Dario Graceffa and Diego Orsini and Viviana Lora and Antonio Giovanni Richetta and Annunziata Dattola and Simone Amato and Nicoletta Bernardini and Paola Tribuzi and Arianna Zangrilli and Martina Vultaggio and Luca Bianchi and Giacomo Caldarola and Eleonora De Luca and Clara De Simone and Domenico Giordano and Cinzia Masini and Mauro Bavetta and Stefania Lechiancole and Vincenzo Panasiti and Damiano Abeni},
  journal = {Dermatology practical \& conceptual},
  year = {2026},
  month = jul,
  doi = {10.5826/dpc.1603a6163},
  url = {https://europepmc.org/article/MED/42858446},
  note = {CC BY-NC},
}
RIS
TY  - JOUR
TI  - Interplay of Biological Treatment and Psychological Features in Patients with Psoriasis: A Real-Life Prospective Study.
AU  - Gaia Moretta
AU  - Tonia Samela
AU  - Alessia Provini
AU  - Gianluca Pagnanelli
AU  - Dario Graceffa
AU  - Diego Orsini
AU  - Viviana Lora
AU  - Antonio Giovanni Richetta
AU  - Annunziata Dattola
AU  - Simone Amato
AU  - Nicoletta Bernardini
AU  - Paola Tribuzi
AU  - Arianna Zangrilli
AU  - Martina Vultaggio
AU  - Luca Bianchi
AU  - Giacomo Caldarola
AU  - Eleonora De Luca
AU  - Clara De Simone
AU  - Domenico Giordano
AU  - Cinzia Masini
AU  - Mauro Bavetta
AU  - Stefania Lechiancole
AU  - Vincenzo Panasiti
AU  - Damiano Abeni
PY  - 2026
DA  - 2026/07/31
JO  - Dermatology practical & conceptual
DO  - 10.5826/dpc.1603a6163
UR  - https://europepmc.org/article/MED/42858446
AB  - Introduction  Emotional dysregulation (ED), common among patients with psoriasis, leads to psychopathology and impairs treatment adherence.Objective  This study examined the changes in prevalence of ED in patients and its effects on illness perception, mental health, and quality of life (QoL) during one year of treatment with risankizumab.Method  ED, illness perception, general health, and QoL were measured at baseline, and at four, 16, and 52 weeks posttreatment in 58 patients with psoriasis.Results  Higher ED was associated with greater psychological distress and poorer QoL. Patients with higher levels of ED reported greater psychological distress, worse QoL, and higher symptom-related distress throughout treatment as compared to those with lower ones. Although both groups improved in terms of illness perception and clinical severity outcomes, patients with high ED consistently experienced worse subjective outcomes.Conclusion  ED is frequent in psoriasis patients and negatively affects mental health and QoL, despite clinical improvements in skin symptoms. Targeted psychological interventions may be necessary for patients who exhibit higher levels of emotional dysregulation to ensure comprehensive care and better long-term outcomes.
SN  - 2160-9381
ER  -