Autonomic nervous system dysfunction in critically ill cancer patients: Hemodynamic consequences and multimodal assessment strategies☆
- 1Department of Critical Care Medicine, Peking Union Medical College Hospital, CAMS, Beijing, 100730, China.
Abstract
In critically ill cancer patients, autonomic nervous system (ANS) dysfunction may contribute to hemodynamic instability and organ dysfunction and may be exacerbated by malignancy-related injury and anticancer treatment. This narrative review summarizes conventional methods for assessing ANS function, including heart rate variability (HRV), blood pressure variability (BPV), baroreflex sensitivity (BRS), and cardiovascular autonomic reflex testing, together with emerging approaches such as high-resolution multimodal monitoring (MMM) and artificial intelligence (AI). Host-organ unregulated response (HOUR) framework is used to integrate interactions among autonomic, neuroendocrine, inflammatory, immune, coagulation, metabolic, bioenergetic, and microcirculatory dysregulation. Collectively, these approaches may facilitate real-time assessment of autonomic function and tissue perfusion, thereby supporting risk stratification and individualized management in critically ill cancer patients.
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BibTeX
@article{gong2026autonomic,
title = {{Autonomic nervous system dysfunction in critically ill cancer patients: Hemodynamic consequences and multimodal assessment strategies☆}},
author = {Shiyi Gong and Yun Chu and Xiaoting Wang},
journal = {Cancer pathogenesis and therapy},
year = {2026},
month = oct,
doi = {10.1016/j.cpt.2026.08.001},
url = {https://europepmc.org/article/PMC/PMC13717020},
note = {CC BY},
}
RIS
TY - JOUR
TI - Autonomic nervous system dysfunction in critically ill cancer patients: Hemodynamic consequences and multimodal assessment strategies☆
AU - Shiyi Gong
AU - Yun Chu
AU - Xiaoting Wang
PY - 2026
DA - 2026/10/21
JO - Cancer pathogenesis and therapy
DO - 10.1016/j.cpt.2026.08.001
UR - https://europepmc.org/article/PMC/PMC13717020
AB - In critically ill cancer patients, autonomic nervous system (ANS) dysfunction may contribute to hemodynamic instability and organ dysfunction and may be exacerbated by malignancy-related injury and anticancer treatment. This narrative review summarizes conventional methods for assessing ANS function, including heart rate variability (HRV), blood pressure variability (BPV), baroreflex sensitivity (BRS), and cardiovascular autonomic reflex testing, together with emerging approaches such as high-resolution multimodal monitoring (MMM) and artificial intelligence (AI). Host-organ unregulated response (HOUR) framework is used to integrate interactions among autonomic, neuroendocrine, inflammatory, immune, coagulation, metabolic, bioenergetic, and microcirculatory dysregulation. Collectively, these approaches may facilitate real-time assessment of autonomic function and tissue perfusion, thereby supporting risk stratification and individualized management in critically ill cancer patients.
SN - 2097-2563
SN - 2949-7132
ER -