Sex-related differences in antimicrobial dosing for sepsis: Bridging the equity gap

Abstract

Sepsis, defined as life-threatening organ dysfunction caused by a dysregulated host response to infection, remains a major challenge in critical care and a leading cause of mortality worldwide. Early, appropriate antibiotic administration is among the most effective strategies to improve outcomes, making optimization of antimicrobial therapy a priority. Optimal antibiotic therapy is the careful selection of the agent and dosing regimen that optimizes outcomes while minimizing adverse effects and antimicrobial resistance. Yet, paradoxically, dosing regimens in sepsis often rely on standardized protocols that overlook fundamental biological variables such as sex and gender, as well as intersecting factors like socioeconomic status, ethnicity, and access to care. This omission compromises efficacy and perpetuates clinical inequalities [...].

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BibTeX RIS

BibTeX

@article{barrasa2026sexrelated,
  title = {{Sex-related differences in antimicrobial dosing for sepsis: Bridging the equity gap}},
  author = {Helena Barrasa and Goiatz Balziskueta and Jordi Rello},
  journal = {Journal of Intensive Medicine},
  year = {2026},
  month = oct,
  doi = {10.1016/j.jointm.2025.08.004},
  url = {https://hal.science/hal-05806389v1},
  note = {CC BY-NC-ND 4.0},
}

RIS

TY  - JOUR
TI  - Sex-related differences in antimicrobial dosing for sepsis: Bridging the equity gap
AU  - Helena Barrasa
AU  - Goiatz Balziskueta
AU  - Jordi Rello
PY  - 2026
DA  - 2026/10/19
JO  - Journal of Intensive Medicine
DO  - 10.1016/j.jointm.2025.08.004
UR  - https://hal.science/hal-05806389v1
AB  - Sepsis, defined as life-threatening organ dysfunction caused by a dysregulated host response to infection, remains a major challenge in critical care and a leading cause of mortality worldwide. Early, appropriate antibiotic administration is among the most effective strategies to improve outcomes, making optimization of antimicrobial therapy a priority. Optimal antibiotic therapy is the careful selection of the agent and dosing regimen that optimizes outcomes while minimizing adverse effects and antimicrobial resistance. Yet, paradoxically, dosing regimens in sepsis often rely on standardized protocols that overlook fundamental biological variables such as sex and gender, as well as intersecting factors like socioeconomic status, ethnicity, and access to care. This omission compromises efficacy and perpetuates clinical inequalities [...].
SN  - 2667-100X
ER  -

Abstract

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