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Peer-reviewedCC BY 4.0Oncology Research

Biochanin A Induces Cuproptosis and Inhibits Lung Metastasis in triple-negative Breast Cancer

  • Limei Zhang1,2
  • Yue Duan1
  • Shuang Pu1
  • Pingting Chen1,3
  • Xiaofang Xie4
  • Yiming Liu5
  • Zhaokai Zhou6
  • Hailin Tang7
  • Lei Yu2
  • Danping Chen3
  • Fu Peng1,8
8 affiliations
  1. 1West China School of Pharmacy, Sichuan University, Chengdu, China
  2. 2Department of Oncology, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, China
  3. 3The First Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, China
  4. 4State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, China
  5. 5Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
  6. 6Department of Urology, The Second Xiangya Hospital of Central South University, Changsha, China
  7. 7State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-Sen University Cancer Center, Guangzhou, China
  8. 8Department of Pharmacology, Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, Sichuan University, Chengdu, China
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Abstract

Background: Triple-negative breast cancer (TNBC) constitutes an invasive breast tumor subtype, marked by scarce available therapies and unfavorable patient prognosis. Natural products have attracted increasing attention as potential anticancer agents due to their multitarget activities and relatively low toxicity. This study aimed to investigate the antitumor effects of Biochanin A (BCA) in TNBC and to explore its underlying molecular mechanisms. Methods: The effects of BCA on TNBC cell proliferation, migration, and invasion were evaluated in vitro. Transcriptomic profiling, network pharmacology analysis, and mechanistic experiments were conducted to investigate the potential involvement of cuproptosis. The antimetastatic effects of BCA were further assessed in vivo using a mouse model. Results: BCA significantly inhibited the proliferative, migratory, and invasive capacities of TNBC cells. Integrative bioinformatics analyses identified cuproptosis as a potential mechanism underlying its antitumor activity. Mechanistic investigations suggested that BCA induces cuproptosis, accompanied by dysregulation of copper homeostasis, increased oxidative stress, mitochondrial dysfunction, and altered expression of cuproptosis-related proteins. Bioinformatics analysis further suggested that LIPT1 may be involved in this process. In vivo experiments demonstrated that BCA markedly suppressed lung metastasis in TNBC mouse models. Conclusions: BCA exhibits potent antitumor and antimetastatic activities against TNBC, potentially through the induction of cuproptosis, with LIPT1 possibly involved in this process. These findings provide experimental evidence supporting further investigation of BCA as a promising therapeutic candidate for TNBC.

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Cite

BibTeXRIS
BibTeX
@article{zhang2026biochanin,
  title = {{Biochanin A Induces Cuproptosis and Inhibits Lung Metastasis in triple-negative Breast Cancer}},
  author = {Limei Zhang and Yue Duan and Shuang Pu and Pingting Chen and Xiaofang Xie and Yiming Liu and Zhaokai Zhou and Hailin Tang and Lei Yu and Danping Chen and Fu Peng},
  journal = {Oncology Research},
  year = {2026},
  month = oct,
  doi = {10.32604/or.2026.084760},
  url = {https://doi.org/10.32604/or.2026.084760},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Biochanin A Induces Cuproptosis and Inhibits Lung Metastasis in triple-negative Breast Cancer
AU  - Limei Zhang
AU  - Yue Duan
AU  - Shuang Pu
AU  - Pingting Chen
AU  - Xiaofang Xie
AU  - Yiming Liu
AU  - Zhaokai Zhou
AU  - Hailin Tang
AU  - Lei Yu
AU  - Danping Chen
AU  - Fu Peng
PY  - 2026
DA  - 2026/10/28
JO  - Oncology Research
DO  - 10.32604/or.2026.084760
UR  - https://doi.org/10.32604/or.2026.084760
AB  - Background: Triple-negative breast cancer (TNBC) constitutes an invasive breast tumor subtype, marked by scarce available therapies and unfavorable patient prognosis. Natural products have attracted increasing attention as potential anticancer agents due to their multitarget activities and relatively low toxicity. This study aimed to investigate the antitumor effects of Biochanin A (BCA) in TNBC and to explore its underlying molecular mechanisms. Methods: The effects of BCA on TNBC cell proliferation, migration, and invasion were evaluated in vitro. Transcriptomic profiling, network pharmacology analysis, and mechanistic experiments were conducted to investigate the potential involvement of cuproptosis. The antimetastatic effects of BCA were further assessed in vivo using a mouse model. Results: BCA significantly inhibited the proliferative, migratory, and invasive capacities of TNBC cells. Integrative bioinformatics analyses identified cuproptosis as a potential mechanism underlying its antitumor activity. Mechanistic investigations suggested that BCA induces cuproptosis, accompanied by dysregulation of copper homeostasis, increased oxidative stress, mitochondrial dysfunction, and altered expression of cuproptosis-related proteins. Bioinformatics analysis further suggested that LIPT1 may be involved in this process. In vivo experiments demonstrated that BCA markedly suppressed lung metastasis in TNBC mouse models. Conclusions: BCA exhibits potent antitumor and antimetastatic activities against TNBC, potentially through the induction of cuproptosis, with LIPT1 possibly involved in this process. These findings provide experimental evidence supporting further investigation of BCA as a promising therapeutic candidate for TNBC.
SN  - 0965-0407
SN  - 1555-3906
ER  -