Peer-reviewedCC BY-NC-NDChemistry & biodiversity
Triterpenes with α-Glucosidase Inhibitory Activity from Euphorbia antiquorum.
- 1School of Chemistry and Chemical Engineering, University of Jinan, Jinan, China.
- 2School of Biological Science and Technology, University of Jinan, Jinan, China.
Abstract
Four previously undescribed Euphane triterpenes, comprising three dynamic epimerization pairs (1-3) and a tetranor derivative (5), as well as eight known analogues (4 and 6-12), have been separated from the tubers of Euphorbia antiquorum. Their structures were characterized by spectroscopic methods, including HR-ESIMS, NMR and ECD. All of them were evaluated for their inhibitory activity against the diabetic target α-glucosidase. Compound 5 exhibited the most potent activity with an IC₅₀ value of 13.6 µM. The binding mode of 5 to α-glucosidase was further investigated, which identified it as a mixed-type inhibitor.
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BibTeX
@article{ma2026triterpenes,
title = {{Triterpenes with α-Glucosidase Inhibitory Activity from Euphorbia antiquorum.}},
author = {Ren-Fen Ma and Chen-Yu Wang and Kai-Yue Liu and Hua Zhang},
journal = {Chemistry \& biodiversity},
year = {2026},
month = oct,
doi = {10.1002/cbdv.71823},
url = {https://europepmc.org/article/MED/42902916},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Triterpenes with α-Glucosidase Inhibitory Activity from Euphorbia antiquorum.
AU - Ren-Fen Ma
AU - Chen-Yu Wang
AU - Kai-Yue Liu
AU - Hua Zhang
PY - 2026
DA - 2026/10/01
JO - Chemistry & biodiversity
DO - 10.1002/cbdv.71823
UR - https://europepmc.org/article/MED/42902916
AB - Four previously undescribed Euphane triterpenes, comprising three dynamic epimerization pairs (1-3) and a tetranor derivative (5), as well as eight known analogues (4 and 6-12), have been separated from the tubers of Euphorbia antiquorum. Their structures were characterized by spectroscopic methods, including HR-ESIMS, NMR and ECD. All of them were evaluated for their inhibitory activity against the diabetic target α-glucosidase. Compound 5 exhibited the most potent activity with an IC₅₀ value of 13.6 µM. The binding mode of 5 to α-glucosidase was further investigated, which identified it as a mixed-type inhibitor.
SN - 1612-1872
SN - 1612-1880
ER -