Skip to content
DraconiticResearch
Search Sources API
181,686 studies31 sourcesUpdated 6 min ago
Peer-reviewedCC BYAntioxidants (Basel, Switzerland)

Exogenous ATP Attenuates Biochemical and Histological Markers of Osimertinib-Associated Myocardial Injury in Rats

  • Engin Hendem1
  • Esra Tuba Sezgin2
  • Bahadir Suleyman3
  • Renad Mammadov3
  • Sevinc Haciyeva4
  • Mustafa Ozkaraca5
  • Taha Abdulkadir Coban6
  • Halis Suleyman3
6 affiliations
  1. 1Department of Medical Oncology, Mengucek Gazi Education and Research Hospital, Erzincan Binali Yıldırım University, Erzincan 24100, Turkey;
  2. 2Anesthesia Program, Vocational School of Health Services, Erzincan Binali Yıldırım University, Erzincan 24036, Turkey;
  3. 3Department of Medical Pharmacology, Faculty of Medicine, Erzincan Binali Yıldırım University, Erzincan 24100, Turkey; (B.S.); (R.M.)
  4. 4Department of Pathological Physiology, Azerbaijan Medical University, Baku AZ1000, Azerbaijan;
  5. 5Department of Pathology, Faculty of Veterinary Medicine, Sivas Cumhuriyet University, Sivas 58140, Turkey;
  6. 6Department of Medical Biochemistry, Faculty of Medicine, Erzincan Binali Yıldırım University, Erzincan 24100, Turkey;
Read full textPDFDOICite

Abstract

(1) Background: Osimertinib is an effective third-generation EGFR tyrosine kinase inhibitor, but its clinical use may be limited by cardiotoxicity. This study investigated the relationship between reduced measured cardiac ATP levels and osimertinib-associated cardiac injury and examined whether exogenous ATP administration attenuates the associated biochemical and histopathological alterations. (2) Methods: Twenty-four male Wistar rats were randomly allocated to healthy control (HG), osimertinib (OSM), ATP 5 mg/kg + osimertinib (AOSM-5), and ATP 10 mg/kg + osimertinib (AOSM-10) groups (n = 6). ATP was administered intraperitoneally once daily, followed 1 h later by osimertinib (50 mg/kg, oral gavage) for three weeks. Cardiac tissue ATP, MDA, and tGSH levels, SOD and CAT activities, and plasma TPI levels were measured, together with histopathological and immunohistochemical evaluation of COX-1, COX-2, and 8-OHdG. (3) Results: Osimertinib significantly decreased ATP and tGSH levels and SOD and CAT activities, and increased MDA and TPI levels (p < 0.001), accompanied by increased COX-2 and 8-OHdG, reduced COX-1, hemorrhage, and mononuclear cell infiltration. Exogenous ATP attenuated these alterations, with generally greater effects observed at 10 mg/kg. (4) Conclusions: These findings indicate that ATP co-administration attenuated biochemical, histopathological, and immunohistochemical alterations associated with osimertinib-induced myocardial injury in rats, with these effects being associated, at least in part, with reduced oxidative stress. However, the functional cardiac effects, underlying mechanisms, and potential influence of ATP administration on the antitumor efficacy of osimertinib require further investigation.

Related

  1. Dietary Macronutrient Composition Is Associated with Distinct Hepatic Phenotypes During Post-Weaning Growth: An Integrated Biochemical, Histological, Immunohistochemical and Ultrastructural Study
    Emrah Zayman, Elif Kayhan, Mehmet Erman Erdemli +3
    MetabolitesPeer-reviewedCC BY 4.0Full textEpidemiology & public healthCrossrefEurope PMC
  2. Tartrazine-Induced Toxicity Is Attenuated by Naringenin in Wistar Rats: A Biochemical, Histological, and Behavioral Study
    Eduardo Rivadeneyra-Domínguez, Juan Francisco Rodríguez-Landa, David J. Salazar-Camacho +5
    NutrientsPeer-reviewedCC BYFull textNutritionEurope PMC
  3. Protective effects of vanillic acid against isoprenaline-induced heart failure in Wistar rats: A biochemical and histological investigation
    Mojtaba Khaksarian, Naser Pajouhi, Afshin Nazari +2
    ARYA AtherosclerosisPeer-reviewedCC BY-NC 4.0Full textCardiovascular medicinePMC
  4. Neuroprotection after transient middle cerebral artery occlusion in male rats using kojic acid nanostructured lipid carriers: A behavioral, biochemical, and histological study on hippocampal CA1 region
    Mobina Gheibi, Erfan Ghadirzadeh, Javid Tebyani +9
    Animal Models and Experimental MedicinePeer-reviewedCC BY-NC 4.0Full textNeurologyPMC
  5. α-Lipoic Acid and Deferoxamine Restore Redox–Metallomic Homeostasis in Dapsone Toxicity: Integrated Biochemical, Histological, and Molecular Modeling Evidence
    Rana Karen Mesquita da Silva, Amanda Caroline dos Santos Monteiro, Sara Kerolim Figueiredo Freitas +13
    ACS OmegaPeer-reviewedCC BY 4.0Full textPharmacology & toxicologyCrossrefEurope PMC

Cite

BibTeXRIS
BibTeX
@article{hendem2026exogenous,
  title = {{Exogenous ATP Attenuates Biochemical and Histological Markers of Osimertinib-Associated Myocardial Injury in Rats}},
  author = {Engin Hendem and Esra Tuba Sezgin and Bahadir Suleyman and Renad Mammadov and Sevinc Haciyeva and Mustafa Ozkaraca and Taha Abdulkadir Coban and Halis Suleyman},
  journal = {Antioxidants (Basel, Switzerland)},
  year = {2026},
  month = sep,
  doi = {10.3390/antiox15101227},
  url = {https://europepmc.org/article/PMC/PMC13700597},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Exogenous ATP Attenuates Biochemical and Histological Markers of Osimertinib-Associated Myocardial Injury in Rats
AU  - Engin Hendem
AU  - Esra Tuba Sezgin
AU  - Bahadir Suleyman
AU  - Renad Mammadov
AU  - Sevinc Haciyeva
AU  - Mustafa Ozkaraca
AU  - Taha Abdulkadir Coban
AU  - Halis Suleyman
PY  - 2026
DA  - 2026/09/01
JO  - Antioxidants (Basel, Switzerland)
DO  - 10.3390/antiox15101227
UR  - https://europepmc.org/article/PMC/PMC13700597
AB  - (1) Background: Osimertinib is an effective third-generation EGFR tyrosine kinase inhibitor, but its clinical use may be limited by cardiotoxicity. This study investigated the relationship between reduced measured cardiac ATP levels and osimertinib-associated cardiac injury and examined whether exogenous ATP administration attenuates the associated biochemical and histopathological alterations. (2) Methods: Twenty-four male Wistar rats were randomly allocated to healthy control (HG), osimertinib (OSM), ATP 5 mg/kg + osimertinib (AOSM-5), and ATP 10 mg/kg + osimertinib (AOSM-10) groups (n = 6). ATP was administered intraperitoneally once daily, followed 1 h later by osimertinib (50 mg/kg, oral gavage) for three weeks. Cardiac tissue ATP, MDA, and tGSH levels, SOD and CAT activities, and plasma TPI levels were measured, together with histopathological and immunohistochemical evaluation of COX-1, COX-2, and 8-OHdG. (3) Results: Osimertinib significantly decreased ATP and tGSH levels and SOD and CAT activities, and increased MDA and TPI levels (p < 0.001), accompanied by increased COX-2 and 8-OHdG, reduced COX-1, hemorrhage, and mononuclear cell infiltration. Exogenous ATP attenuated these alterations, with generally greater effects observed at 10 mg/kg. (4) Conclusions: These findings indicate that ATP co-administration attenuated biochemical, histopathological, and immunohistochemical alterations associated with osimertinib-induced myocardial injury in rats, with these effects being associated, at least in part, with reduced oxidative stress. However, the functional cardiac effects, underlying mechanisms, and potential influence of ATP administration on the antitumor efficacy of osimertinib require further investigation.
SN  - 2076-3921
ER  -