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Peer-reviewedCC BY-NC-NDCirculation Journal

Determinants of Disproportionality in Functional Mitral Regurgitation ― Importance of Mitral Valve Morphology ―

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Abstract

BACKGROUND: Disproportionate (d-) functional mitral regurgitation (FMR) is characterized by greater mitral regurgitation (MR) severity than expected from left ventricular (LV) dilatation. Morphological determinants of this imbalance remain unclear. METHODS AND RESULTS: /mL. CONCLUSIONS: Additional morphological factors were associated with greater MR severity beyond LV size and with residual MR after TEER, supporting a phenotype-based interpretation of FMR disproportionality.

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BibTeX
@article{arao2026determinants,
  title = {{Determinants of Disproportionality in Functional Mitral Regurgitation ― Importance of Mitral Valve Morphology ―}},
  author = {Yoshihito Arao and Nobuyuki Kagiyama and Yuki Izumi and Satonori Maekawara and Tomohiro Kaneko and Mai Terada and Mike Saji and Nobuo Iguchi and Ryosuke Higuchi and Itaru Takamisawa and Mamoru Nanasato and Toyoaki Murohara and Mitsuaki Isobe},
  journal = {Circulation Journal},
  year = {2026},
  month = sep,
  doi = {10.1253/circj.cj-26-0057},
  url = {https://www.jstage.jst.go.jp/article/circj/advpub/0/advpub_CJ-26-0057/_article},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Determinants of Disproportionality in Functional Mitral Regurgitation ― Importance of Mitral Valve Morphology ―
AU  - Yoshihito Arao
AU  - Nobuyuki Kagiyama
AU  - Yuki Izumi
AU  - Satonori Maekawara
AU  - Tomohiro Kaneko
AU  - Mai Terada
AU  - Mike Saji
AU  - Nobuo Iguchi
AU  - Ryosuke Higuchi
AU  - Itaru Takamisawa
AU  - Mamoru Nanasato
AU  - Toyoaki Murohara
AU  - Mitsuaki Isobe
PY  - 2026
DA  - 2026/09/16
JO  - Circulation Journal
DO  - 10.1253/circj.cj-26-0057
UR  - https://www.jstage.jst.go.jp/article/circj/advpub/0/advpub_CJ-26-0057/_article
AB  - BACKGROUND: Disproportionate (d-) functional mitral regurgitation (FMR) is characterized by greater mitral regurgitation (MR) severity than expected from left ventricular (LV) dilatation. Morphological determinants of this imbalance remain unclear. METHODS AND RESULTS: /mL. CONCLUSIONS: Additional morphological factors were associated with greater MR severity beyond LV size and with residual MR after TEER, supporting a phenotype-based interpretation of FMR disproportionality.
SN  - 1347-4820
SN  - 1346-9843
ER  -