Effects of manganese dioxide on macrophages under different exposure schemes
Abstract
Manganese dioxide is a material that is more and more used in its particular form, for many industrial applications such as chemical catalysis or for batteries. Thus, workers can be exposed to this particulate chemical. It is known that overexposure to manganese leads to a brain disease called manganism. However, manganese is also known to impact the pulmonary function, which is important as pulmonary exposure is of prime importance for workers. We thus investigated the effects of manganese dioxide on macrophages, i.e. the scavenger cells that take particulates in charge in our bodies. To this purpose, we used a combination of proteomic and targeted approaches, in order to obtain a wide view of the cellular responses to manganese dioxide. We also used a repeated exposure mode, in order to better mimic occupational exposure. Our results point out the fact that manganese oxide nanoparticles are toxic for macrophages and induce mitochondrial dysfunction, oxidative stress and a pro-inflammatory response.
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BibTeX
@article{vitipon2026effects,
title = {{Effects of manganese dioxide on macrophages under different exposure schemes}},
author = {Marianne Vitipon and Esther Akingbagbohun and Véronique Collin-Faure and Fabienne Devime and Hélène Diemer and Daphna Fenel and Christine Carapito and Stéphane Ravanel and Thierry Rabilloud},
journal = {Journal of Hazardous Materials Advances},
year = {2026},
month = sep,
doi = {10.1016/j.hazadv.2026.101337},
url = {https://hal.science/hal-05751761v1},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Effects of manganese dioxide on macrophages under different exposure schemes
AU - Marianne Vitipon
AU - Esther Akingbagbohun
AU - Véronique Collin-Faure
AU - Fabienne Devime
AU - Hélène Diemer
AU - Daphna Fenel
AU - Christine Carapito
AU - Stéphane Ravanel
AU - Thierry Rabilloud
PY - 2026
DA - 2026/09/16
JO - Journal of Hazardous Materials Advances
DO - 10.1016/j.hazadv.2026.101337
UR - https://hal.science/hal-05751761v1
AB - Manganese dioxide is a material that is more and more used in its particular form, for many industrial applications such as chemical catalysis or for batteries. Thus, workers can be exposed to this particulate chemical. It is known that overexposure to manganese leads to a brain disease called manganism. However, manganese is also known to impact the pulmonary function, which is important as pulmonary exposure is of prime importance for workers. We thus investigated the effects of manganese dioxide on macrophages, i.e. the scavenger cells that take particulates in charge in our bodies. To this purpose, we used a combination of proteomic and targeted approaches, in order to obtain a wide view of the cellular responses to manganese dioxide. We also used a repeated exposure mode, in order to better mimic occupational exposure. Our results point out the fact that manganese oxide nanoparticles are toxic for macrophages and induce mitochondrial dysfunction, oxidative stress and a pro-inflammatory response.
SN - 2772-4166
ER -