Vascular Remodelling in Idiopathic Nephrotic Syndrome with Administration of Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers
- 1Syiah Kuala University Faculty of Medicine: Universitas Syiah Kuala Fakultas Kedokteran
Abstract
Pediatric nephrotic syndrome (NS) significantly increases cardiovascular risk, primarily through activation of the renin-angiotensin-aldosterone system (RAAS) and chronic inflammation. This study aimed to evaluate the relationship between serum aldosterone and interleukin 6 (IL-6) levels with carotid intima-media thickness (CIMT) in children with steroid-sensitive (SSNS) and steroid-resistant NS (SRNS), before and after treatment with angiotensin-converting enzyme inhibitors (ACEI) and angiotensin receptor blockers (ARB). This prospective, single-arm pretest-posttest study included 32 children aged 2-18 years with idiopathic NS at Dr. Zainoel Abidin Hospital, Banda Aceh, Indonesia. Participants received lisinopril and valsartan for 12 weeks. Serum aldosterone was quantified by liquid chromatography-tandem mass spectrometry, IL-6 by electrochemiluminescence immunoassay, and CIMT by high-resolution B-mode Doppler ultrasound. Data were analyzed using SPSS version 26.0, including Shapiro-Wilk normality testing, correlation analyses, and multivariate linear regression, with statistical significance set at p<0.05. CIMT decreased significantly after treatment (0.13{+/-}0.04 cm to 0.06{+/-}0.01 cm; p<0.001). Serum aldosterone and IL-6 did not change significantly. Multivariate regression identified steroid resistance as associated with CIMT change, while aldosterone and IL-6 showed no significant independent effects.
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BibTeX
@misc{dimiati2026vascular,
title = {{Vascular Remodelling in Idiopathic Nephrotic Syndrome with Administration of Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers}},
author = {H. Dimiati and S. Haris and K. Hasballah and S. Pardede},
howpublished = {medRxiv},
year = {2026},
month = oct,
doi = {10.64898/2026.10.09.26365110},
url = {https://www.medrxiv.org/content/10.64898/2026.10.09.26365110v1},
note = {CC BY},
}
RIS
TY - UNPB
TI - Vascular Remodelling in Idiopathic Nephrotic Syndrome with Administration of Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers
AU - H. Dimiati
AU - S. Haris
AU - K. Hasballah
AU - S. Pardede
PY - 2026
DA - 2026/10/09
PB - medRxiv
DO - 10.64898/2026.10.09.26365110
UR - https://www.medrxiv.org/content/10.64898/2026.10.09.26365110v1
AB - Pediatric nephrotic syndrome (NS) significantly increases cardiovascular risk, primarily through activation of the renin-angiotensin-aldosterone system (RAAS) and chronic inflammation. This study aimed to evaluate the relationship between serum aldosterone and interleukin 6 (IL-6) levels with carotid intima-media thickness (CIMT) in children with steroid-sensitive (SSNS) and steroid-resistant NS (SRNS), before and after treatment with angiotensin-converting enzyme inhibitors (ACEI) and angiotensin receptor blockers (ARB). This prospective, single-arm pretest-posttest study included 32 children aged 2-18 years with idiopathic NS at Dr. Zainoel Abidin Hospital, Banda Aceh, Indonesia. Participants received lisinopril and valsartan for 12 weeks. Serum aldosterone was quantified by liquid chromatography-tandem mass spectrometry, IL-6 by electrochemiluminescence immunoassay, and CIMT by high-resolution B-mode Doppler ultrasound. Data were analyzed using SPSS version 26.0, including Shapiro-Wilk normality testing, correlation analyses, and multivariate linear regression, with statistical significance set at p<0.05. CIMT decreased significantly after treatment (0.13{+/-}0.04 cm to 0.06{+/-}0.01 cm; p<0.001). Serum aldosterone and IL-6 did not change significantly. Multivariate regression identified steroid resistance as associated with CIMT change, while aldosterone and IL-6 showed no significant independent effects.
ER -