Lymphatic Mapping to the Inguinal Region in Patients with Lower Extremity Melanoma Undergoing Radical Inguinal Lymph Node Dissection: A Retrospective Cohort Study.
4 affiliations
- 1Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Bone and Soft Tissue Tumor, Peking University Cancer Hospital & Institute, 100142 Beijing, China.
- 2Department of Bone and Soft Tissue Oncology, Peking University Cancer Hospital, Inner Mongolia Campus, 010010 Hohhot, China.
- 3Affiliated Cancer Hospital of Inner Mongolia Medical University, 010010 Hohhot, China.
- 4Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Anesthesiology, Peking University Cancer Hospital & Institute, 100142 Beijing, China.
Abstract
Background/objectives
The anatomical distribution of inguinal lymph node (ILN) metastases may inform research on the extent of therapeutic dissection for lower-limb melanoma.Methods
Fifty-eight patients undergoing radical inguinal lymph node dissection (rILND) were retrospectively evaluated using five anatomical zones. Zone-specific node counts were reaggregated, and exploratory binary logistic regression assessed multiple-zone involvement.Results
The cohort included 48 clinically node-positive and 10 sentinel lymph node biopsy (SLNB)-positive patients. Among 816 mapped ILNs, 149 were positive. Zone I contained 102/149 positive nodes (68.5%); within-zone positivity was 102/303 (33.7%) in zone I, 27/243 (11.1%) in zone II, 13/190 (6.8%) in zone III, 3/39 (7.7%) in zone IV, and 4/41 (9.8%) in zone V. Five patients had no positive mapped ILNs. Zone I contained the only positive node in 19/20 patients (95.0%) and was the sole involved zone in 32/33 patients with single-zone involvement (97.0%). Twenty patients had multiple-zone involvement. In a two-variable complete-case model (50 patients; 18 events), ≥3 positive ILNs remained associated with multiple-zone involvement (adjusted odds ratio, 34.80; 95% confidence interval, 5.88-206.08), whereas extranodal extension did not.Conclusions
This small, selected cohort provides preliminary pathological evidence of preferential inferior-zone involvement. It does not establish sequential spread or the oncological safety of reduced rILND. External and prospective validation are required.
Related
- Single-port robotic inguinal lymph node dissection: Optimizing perioperative outcomes with a novel regionalized surgical approach.
- Clinical outcomes of concurrent repair of occult contralateral inguinal hernias during TAPP: a retrospective cohort study
- Lower-extremity Deep Vein Thrombosis after Plastic Surgery: Clinical Characteristics and Outcomes in a Retrospective Case Series
- Adjunctive iliac vein stenting for May-Thurner-associated lower-extremity phlebolymphedema: a dual-center retrospective cohort study
- Long-term outcomes and prognostic factors in patients aged 70 years or older with early esophageal squamous cell carcinoma undergoing endoscopic submucosal dissection
BibTeX
@article{tan2026lymphatic,
title = {{Lymphatic Mapping to the Inguinal Region in Patients with Lower Extremity Melanoma Undergoing Radical Inguinal Lymph Node Dissection: A Retrospective Cohort Study.}},
author = {Zhichao Tan and Yue Sun and Yunxiao Zhang and Zhengfu Fan and Chujie Bai and Shu Li and Tian Gao and Lu Zhang and Ruifeng Xue and Xinyu Wang and Mengmeng Liu and Hairui Wang and Jiayong Liu},
journal = {Cancers},
year = {2026},
month = oct,
doi = {10.3390/cancers18193184},
url = {https://europepmc.org/article/MED/42882878},
note = {CC BY},
}
RIS
TY - JOUR
TI - Lymphatic Mapping to the Inguinal Region in Patients with Lower Extremity Melanoma Undergoing Radical Inguinal Lymph Node Dissection: A Retrospective Cohort Study.
AU - Zhichao Tan
AU - Yue Sun
AU - Yunxiao Zhang
AU - Zhengfu Fan
AU - Chujie Bai
AU - Shu Li
AU - Tian Gao
AU - Lu Zhang
AU - Ruifeng Xue
AU - Xinyu Wang
AU - Mengmeng Liu
AU - Hairui Wang
AU - Jiayong Liu
PY - 2026
DA - 2026/10/02
JO - Cancers
DO - 10.3390/cancers18193184
UR - https://europepmc.org/article/MED/42882878
AB - Background/objectives The anatomical distribution of inguinal lymph node (ILN) metastases may inform research on the extent of therapeutic dissection for lower-limb melanoma.Methods Fifty-eight patients undergoing radical inguinal lymph node dissection (rILND) were retrospectively evaluated using five anatomical zones. Zone-specific node counts were reaggregated, and exploratory binary logistic regression assessed multiple-zone involvement.Results The cohort included 48 clinically node-positive and 10 sentinel lymph node biopsy (SLNB)-positive patients. Among 816 mapped ILNs, 149 were positive. Zone I contained 102/149 positive nodes (68.5%); within-zone positivity was 102/303 (33.7%) in zone I, 27/243 (11.1%) in zone II, 13/190 (6.8%) in zone III, 3/39 (7.7%) in zone IV, and 4/41 (9.8%) in zone V. Five patients had no positive mapped ILNs. Zone I contained the only positive node in 19/20 patients (95.0%) and was the sole involved zone in 32/33 patients with single-zone involvement (97.0%). Twenty patients had multiple-zone involvement. In a two-variable complete-case model (50 patients; 18 events), ≥3 positive ILNs remained associated with multiple-zone involvement (adjusted odds ratio, 34.80; 95% confidence interval, 5.88-206.08), whereas extranodal extension did not.Conclusions This small, selected cohort provides preliminary pathological evidence of preferential inferior-zone involvement. It does not establish sequential spread or the oncological safety of reduced rILND. External and prospective validation are required.
SN - 2072-6694
ER -