Long-term outcomes and prognostic factors in patients aged 70 years or older with early esophageal squamous cell carcinoma undergoing endoscopic submucosal dissection
5 affiliations
- 1Department of Traditional Chinese Medicine, Fourth Hospital of Hebei Medical University, Shijiazhuang, 050011 Hebei China
- 2Outpatient Department, Bachelor of Medicine, Fourth Hospital of Hebei Medical University, Shijiazhuang, 050011 Hebei China
- 3Department of Digestive Endoscope, Fourth Hospital of Hebei Medical University, M.D, Shijiazhuang, 050011 Hebei China
- 4Department of Thoracic Surgery, Fourth Hospital of Hebei Medical University, Shijiazhuang, 050011 Hebei China
- 5Department of Infectious Diseases, Fourth Hospital of Hebei Medical University, M.D, Shijiazhuang, 050011 Hebei China
Abstract
Objectives: Given the aging population, we aimed to evaluate the long-term outcomes and prognostic factors of overall survival (OS) in elderly patients who underwent endoscopic submucosal dissection (ESD) for early esophageal squamous cell carcinoma (ESCC).
Methods: Between January 2000 and June 2022, we analyzed 103 patients aged 70 years or older who underwent ESD for ESCC. The long-term outcomes and prognoses were evaluated, and independent risk factors for OS were identified.
Results: The median age of the patients was 76.9 years (range 70–85 years). The 1-year, 3-year and 5-year OS rates in the curative resection group were 100%, 95.4% and 91.1%, respectively, while those in the noncurative resection group were 98.9%, 87.5% and 73.8%, respectively. The difference was statistically significant (P = 0.029). The 1-year, 3-year and 5-year disease-specific survival (DSS) rates in the curative resection group were 100%, 100% and 96.4%, respectively, while the DSS rates in the noncurative resection group were 100%, 100% and 78.4%, respectively, with no statistical significance (P = 0.090). Univariate analysis revealed that smoking, heavy alcohol consumption, cardiovascular disease, cerebrovascular disease, a history of cancer in other organs, a GNRI < 97.7, an NLR > 2.3, an ASA-PS, a CCI ≥ 3, the presence of LVI, and noncurative ESD were significantly associated with OS. Multivariate analysis revealed that a CCI ≥ 3 (P = 0.001) and a GNRI < 97.7 (P < 0.001) were independent risk factors for OS.
Conclusions: The results revealed that a GNRI < 97.7 and a CCI ≥ 3 were significantly associated with poor prognosis in elderly patients undergoing ESD for early ESCC.
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BibTeX
@article{li2026longterm,
title = {{Long-term outcomes and prognostic factors in patients aged 70 years or older with early esophageal squamous cell carcinoma undergoing endoscopic submucosal dissection}},
author = {Jian-bo Li and Wei Wei and Shuo Guo and Bao-Qing Li and Yong Feng},
journal = {Langenbeck's Archives of Surgery},
year = {2026},
month = sep,
doi = {10.1007/s00423-026-04272-3},
url = {https://doi.org/10.1007/s00423-026-04272-3},
note = {CC BY-NC-ND 4.0},
}
RIS
TY - JOUR
TI - Long-term outcomes and prognostic factors in patients aged 70 years or older with early esophageal squamous cell carcinoma undergoing endoscopic submucosal dissection
AU - Jian-bo Li
AU - Wei Wei
AU - Shuo Guo
AU - Bao-Qing Li
AU - Yong Feng
PY - 2026
DA - 2026/09/17
JO - Langenbeck's Archives of Surgery
DO - 10.1007/s00423-026-04272-3
UR - https://doi.org/10.1007/s00423-026-04272-3
AB - Objectives: Given the aging population, we aimed to evaluate the long-term outcomes and prognostic factors of overall survival (OS) in elderly patients who underwent endoscopic submucosal dissection (ESD) for early esophageal squamous cell carcinoma (ESCC). Methods: Between January 2000 and June 2022, we analyzed 103 patients aged 70 years or older who underwent ESD for ESCC. The long-term outcomes and prognoses were evaluated, and independent risk factors for OS were identified. Results: The median age of the patients was 76.9 years (range 70–85 years). The 1-year, 3-year and 5-year OS rates in the curative resection group were 100%, 95.4% and 91.1%, respectively, while those in the noncurative resection group were 98.9%, 87.5% and 73.8%, respectively. The difference was statistically significant (P = 0.029). The 1-year, 3-year and 5-year disease-specific survival (DSS) rates in the curative resection group were 100%, 100% and 96.4%, respectively, while the DSS rates in the noncurative resection group were 100%, 100% and 78.4%, respectively, with no statistical significance (P = 0.090). Univariate analysis revealed that smoking, heavy alcohol consumption, cardiovascular disease, cerebrovascular disease, a history of cancer in other organs, a GNRI < 97.7, an NLR > 2.3, an ASA-PS, a CCI ≥ 3, the presence of LVI, and noncurative ESD were significantly associated with OS. Multivariate analysis revealed that a CCI ≥ 3 (P = 0.001) and a GNRI < 97.7 (P < 0.001) were independent risk factors for OS. Conclusions: The results revealed that a GNRI < 97.7 and a CCI ≥ 3 were significantly associated with poor prognosis in elderly patients undergoing ESD for early ESCC.
SN - 1435-2443
SN - 1435-2451
ER -