Mature dendritic cells suppress tenocyte and fibroblast function via type I interferon signaling
- 1Center for Pathophysiology, Infectiology and Immunology, Institute of Immunology, Medical University of Vienna
- 2Department of Dermatology, Medical University of Vienna
- 3Department of Medicine, Surgery and Dentistry, University of Salerno
Abstract
Dendritic cells (DCs) play a critical role in modulating immune responses and tissue homeostasis. While immature DCs have been shown to enhance cell proliferation, the function of mature DCs (mDCs) in connective tissue biology remains less well understood. Here, we report that mDCs exert a potent inhibitory effect on tenocytes (TCs) and fibroblasts (FBs), suppressing both cell proliferation and type I collagen production. Using in vitro co-culture and supernatant transfer experiments, we demonstrate that this suppression is primarily mediated by soluble factors. Further mechanistic analysis revealed that type I interferons (IFN-α, IFN-β, IFN-ω), produced by mDCs upon LPS-induced maturation, are key mediators of these effects. Neutralization of the type I IFN signaling pathway restored both proliferation and collagen synthesis in TCs and FBs, confirming the central role of IFN signaling. Our findings suggest that mDCs may contribute to impaired tissue regeneration in inflammatory tendon pathologies.
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BibTeX
@article{pinnaro2026mature,
title = {{Mature dendritic cells suppress tenocyte and fibroblast function via type I interferon signaling}},
author = {Veronica Pinnarò and Sonia V. Rodriguez Monje and Sarojinidevi Künig and Nico Lamot and Adelheid Elbe-Bürger and Maria Camilla Ciardulli and Giovanna Della Porta and Johannes Stöckl},
journal = {Frontiers in Immunology},
year = {2026},
month = oct,
doi = {10.3389/fimmu.2026.1933065},
url = {https://www.frontiersin.org/articles/10.3389/fimmu.2026.1933065/full},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Mature dendritic cells suppress tenocyte and fibroblast function via type I interferon signaling
AU - Veronica Pinnarò
AU - Sonia V. Rodriguez Monje
AU - Sarojinidevi Künig
AU - Nico Lamot
AU - Adelheid Elbe-Bürger
AU - Maria Camilla Ciardulli
AU - Giovanna Della Porta
AU - Johannes Stöckl
PY - 2026
DA - 2026/10/14
JO - Frontiers in Immunology
DO - 10.3389/fimmu.2026.1933065
UR - https://www.frontiersin.org/articles/10.3389/fimmu.2026.1933065/full
AB - Dendritic cells (DCs) play a critical role in modulating immune responses and tissue homeostasis. While immature DCs have been shown to enhance cell proliferation, the function of mature DCs (mDCs) in connective tissue biology remains less well understood. Here, we report that mDCs exert a potent inhibitory effect on tenocytes (TCs) and fibroblasts (FBs), suppressing both cell proliferation and type I collagen production. Using in vitro co-culture and supernatant transfer experiments, we demonstrate that this suppression is primarily mediated by soluble factors. Further mechanistic analysis revealed that type I interferons (IFN-α, IFN-β, IFN-ω), produced by mDCs upon LPS-induced maturation, are key mediators of these effects. Neutralization of the type I IFN signaling pathway restored both proliferation and collagen synthesis in TCs and FBs, confirming the central role of IFN signaling. Our findings suggest that mDCs may contribute to impaired tissue regeneration in inflammatory tendon pathologies.
SN - 1664-3224
ER -