Rapidly Enlarging Giant Intramuscular Myxoma of the Distal Gluteus Maximus during Late Pregnancy.
- 1Department of Orthopaedics and Traumatology, Ufuk University Medical Faculty, Ankara, Turkey.
Abstract
Intramuscular myxoma is a rare benign mesenchymal tumor of skeletal muscle that usually presents as a slowly enlarging, painless mass. We report a giant intramuscular myxoma of the distal gluteus maximus in a 34-year-old woman. The lesion became clinically apparent during the third trimester of her first pregnancy and enlarged rapidly over approximately 6 months. Three months after cesarean delivery, she presented with severe sitting intolerance, difficulty breastfeeding while seated, and burning pain radiating along the sciatic nerve distribution. Magnetic resonance imaging demonstrated an approximately 154 × 155 × 156 mm well-circumscribed intramuscular mass adjacent to the ischium and compressing the sciatic nerve, without osseous destruction; however, its rapid growth and imaging features raised concern for a malignant myxoid soft-tissue neoplasm. A preoperative core needle biopsy showed fibrous and myxoid tissue, with no atypia or malignant cells identified in the sampled material. Complete en bloc excision was performed. Histopathologic and immunohistochemical evaluation confirmed intramuscular myxoma, and the closest surgical margin was 1 cm. The postoperative course was uneventful; symptoms resolved, she was able to continue breastfeeding, and no clinically evident local recurrence was observed during 24 months of clinical follow-up. This case highlights that a histologically benign intramuscular myxoma may exhibit rapid growth during late pregnancy, reach giant size, and mimic a malignant process, thereby creating substantial preoperative diagnostic uncertainty.
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BibTeX
@article{guneri2026rapidly,
title = {{Rapidly Enlarging Giant Intramuscular Myxoma of the Distal Gluteus Maximus during Late Pregnancy.}},
author = {Cem Güneri and Yasin Köker and İsmet Teoman Benli},
journal = {Journal of orthopaedic case reports},
year = {2026},
month = nov,
doi = {10.13107/jocr.2026.v16.i11.8420},
url = {https://europepmc.org/article/MED/42997035},
note = {CC BY-NC},
}
RIS
TY - JOUR
TI - Rapidly Enlarging Giant Intramuscular Myxoma of the Distal Gluteus Maximus during Late Pregnancy.
AU - Cem Güneri
AU - Yasin Köker
AU - İsmet Teoman Benli
PY - 2026
DA - 2026/11/01
JO - Journal of orthopaedic case reports
DO - 10.13107/jocr.2026.v16.i11.8420
UR - https://europepmc.org/article/MED/42997035
AB - Intramuscular myxoma is a rare benign mesenchymal tumor of skeletal muscle that usually presents as a slowly enlarging, painless mass. We report a giant intramuscular myxoma of the distal gluteus maximus in a 34-year-old woman. The lesion became clinically apparent during the third trimester of her first pregnancy and enlarged rapidly over approximately 6 months. Three months after cesarean delivery, she presented with severe sitting intolerance, difficulty breastfeeding while seated, and burning pain radiating along the sciatic nerve distribution. Magnetic resonance imaging demonstrated an approximately 154 × 155 × 156 mm well-circumscribed intramuscular mass adjacent to the ischium and compressing the sciatic nerve, without osseous destruction; however, its rapid growth and imaging features raised concern for a malignant myxoid soft-tissue neoplasm. A preoperative core needle biopsy showed fibrous and myxoid tissue, with no atypia or malignant cells identified in the sampled material. Complete en bloc excision was performed. Histopathologic and immunohistochemical evaluation confirmed intramuscular myxoma, and the closest surgical margin was 1 cm. The postoperative course was uneventful; symptoms resolved, she was able to continue breastfeeding, and no clinically evident local recurrence was observed during 24 months of clinical follow-up. This case highlights that a histologically benign intramuscular myxoma may exhibit rapid growth during late pregnancy, reach giant size, and mimic a malignant process, thereby creating substantial preoperative diagnostic uncertainty.
SN - 2250-0685
SN - 2321-3817
ER -