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Peer-reviewedCC BY-NCClinical case reports

Diffuse Large B-Cell Lymphoma Presenting as a Rapidly Enlarging Forehead Mass Initially Suggestive of a Subgaleal Hematoma: A Case Report.

  • Akitomo Yonenaga1,2
  • Nobuo Isono1
  • Ami Higashiyama1
  • Masao Tsukada3
  • Keijiro Hori2
  1. 1Department of Plastic and Reconstructive Surgery Tokyo Metropolitan Tama Medical Center Tokyo Japan.
  2. 2Department of Plastic and Reconstructive Surgery Tokyo Women's Medical University Adachi Medical Center Tokyo Japan.
  3. 3Department of Hematology Tokyo Metropolitan Tama Medical Center Tokyo Japan.
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Abstract

While diffuse large B-cell lymphoma (DLBCL) occurring in the subcutaneous soft tissue is extremely rare, we present herein a case of DLBCL occurring in the forehead. A 70-year-old woman presented to the plastic and reconstructive department with a painless forehead mass. Although magnetic resonance imaging (MRI) initially suggested a subgaleal hematoma, subsequent computed tomography (CT) revealed bone destruction. Due to the progressive enlargement, a biopsy was performed, confirming a pathological diagnosis of DLBCL. A genetic analysis of tissue samples revealed MYC and BCL6 rearrangements consistent with double-hit lymphoma (DHL). The patient was treated with the help of R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) followed by DA-R-EPOCH (dose-adjusted rituximab, etoposide, prednisone, vincristine, cyclophosphamide, and doxorubicin). Although the frontal skull mass completely resolved, residual disease persisted in the femur, ultimately leading to the patient's death. This case highlights the importance of including lymphoma in the differential diagnosis of rapidly enlarging soft tissue masses as well as the utility of early biopsy in ensuring timely intervention.

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Cite

BibTeXRIS
BibTeX
@article{yonenaga2026diffuse,
  title = {{Diffuse Large B-Cell Lymphoma Presenting as a Rapidly Enlarging Forehead Mass Initially Suggestive of a Subgaleal Hematoma: A Case Report.}},
  author = {Akitomo Yonenaga and Nobuo Isono and Ami Higashiyama and Masao Tsukada and Keijiro Hori},
  journal = {Clinical case reports},
  year = {2026},
  month = nov,
  doi = {10.1002/ccr3.73850},
  url = {https://europepmc.org/article/MED/42997330},
  note = {CC BY-NC},
}
RIS
TY  - JOUR
TI  - Diffuse Large B-Cell Lymphoma Presenting as a Rapidly Enlarging Forehead Mass Initially Suggestive of a Subgaleal Hematoma: A Case Report.
AU  - Akitomo Yonenaga
AU  - Nobuo Isono
AU  - Ami Higashiyama
AU  - Masao Tsukada
AU  - Keijiro Hori
PY  - 2026
DA  - 2026/11/06
JO  - Clinical case reports
DO  - 10.1002/ccr3.73850
UR  - https://europepmc.org/article/MED/42997330
AB  - While diffuse large B-cell lymphoma (DLBCL) occurring in the subcutaneous soft tissue is extremely rare, we present herein a case of DLBCL occurring in the forehead. A 70-year-old woman presented to the plastic and reconstructive department with a painless forehead mass. Although magnetic resonance imaging (MRI) initially suggested a subgaleal hematoma, subsequent computed tomography (CT) revealed bone destruction. Due to the progressive enlargement, a biopsy was performed, confirming a pathological diagnosis of DLBCL. A genetic analysis of tissue samples revealed MYC and BCL6 rearrangements consistent with double-hit lymphoma (DHL). The patient was treated with the help of R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) followed by DA-R-EPOCH (dose-adjusted rituximab, etoposide, prednisone, vincristine, cyclophosphamide, and doxorubicin). Although the frontal skull mass completely resolved, residual disease persisted in the femur, ultimately leading to the patient's death. This case highlights the importance of including lymphoma in the differential diagnosis of rapidly enlarging soft tissue masses as well as the utility of early biopsy in ensuring timely intervention.
SN  - 2050-0904
ER  -