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Peer-reviewedCC BYAdvanced Materials

Recent Advances in Ferrite‐Based Materials for Biomedical Applications: A Comprehensive Review

  • Pramod D. Mhase1
  • Varsha C. Pujari2
  • Akash V. Fulari2
  • Sunil M. Patange1
  • Sean Li3,4
  • Danyang Wang3,4
  • Sagar E. Shirsath3
4 affiliations
  1. 1Materials Science Research Laboratory Shri Krishna Mahavidyalaya Dharashiv Maharashtra India
  2. 2Symbosis Centre for Nanoscience and Nanotechnology Symbiosis International (Deemed University) Pune India
  3. 3School of Materials Science and Engineering University of New South Wales Sydney New South Wales Australia
  4. 4UNSW Materials and Manufacturing Futures Institute University of New South Wales Sydney New South Wales Australia
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Abstract

Ferrite-based nanomaterials have evolved from simple magnetic contrast agents into sophisticated, multifunctional platforms capable of actively regulating biological microenvironments. This comprehensive review critically examines the recent advances in the rational design of spinel and hexagonal ferrites, elucidating the fundamental structure-property-bioactivity relationships that govern their biomedical performance. We explore how atomic-level engineering, specifically cation distribution, defect modulation, and morphological anisotropy, can be manipulated to tailor magnetic susceptibility, catalytic activity (nanozymes), and specific absorption rates (SAR) for hyperthermia. Beyond traditional applications in MRI and drug delivery, we highlight emerging frontiers including viscosity-independent magnetic hyperthermia, ROS-mediated antimicrobial therapy, and magnetic tissue engineering (Mag-TE). Crucially, this review addresses the widening translational gap between high-performance laboratory prototypes and clinical reality. We critically analyze the barriers impeding commercialization, such as the discrepancy between colloidal and intracellular heating efficiency, the complexity of protein corona formation, and the challenges of scalable, GMP-compliant synthesis. Finally, we propose a future roadmap integrating AI-driven material discovery and green chemistry to develop next-generation magnetotheranostic systems, positioning ferrite nanoplatforms as central components in the future of precision medicine.

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Cite

BibTeXRIS
BibTeX
@article{mhase2026recent,
  title = {{Recent Advances in Ferrite‐Based Materials for Biomedical Applications: A Comprehensive Review}},
  author = {Pramod D. Mhase and Varsha C. Pujari and Akash V. Fulari and Sunil M. Patange and Sean Li and Danyang Wang and Sagar E. Shirsath},
  journal = {Advanced Materials},
  year = {2026},
  month = jul,
  doi = {10.1002/adma.74149},
  url = {https://doi.org/10.1002/adma.74149},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Recent Advances in Ferrite‐Based Materials for Biomedical Applications: A Comprehensive Review
AU  - Pramod D. Mhase
AU  - Varsha C. Pujari
AU  - Akash V. Fulari
AU  - Sunil M. Patange
AU  - Sean Li
AU  - Danyang Wang
AU  - Sagar E. Shirsath
PY  - 2026
DA  - 2026/07/21
JO  - Advanced Materials
DO  - 10.1002/adma.74149
UR  - https://doi.org/10.1002/adma.74149
AB  - Ferrite-based nanomaterials have evolved from simple magnetic contrast agents into sophisticated, multifunctional platforms capable of actively regulating biological microenvironments. This comprehensive review critically examines the recent advances in the rational design of spinel and hexagonal ferrites, elucidating the fundamental structure-property-bioactivity relationships that govern their biomedical performance. We explore how atomic-level engineering, specifically cation distribution, defect modulation, and morphological anisotropy, can be manipulated to tailor magnetic susceptibility, catalytic activity (nanozymes), and specific absorption rates (SAR) for hyperthermia. Beyond traditional applications in MRI and drug delivery, we highlight emerging frontiers including viscosity-independent magnetic hyperthermia, ROS-mediated antimicrobial therapy, and magnetic tissue engineering (Mag-TE). Crucially, this review addresses the widening translational gap between high-performance laboratory prototypes and clinical reality. We critically analyze the barriers impeding commercialization, such as the discrepancy between colloidal and intracellular heating efficiency, the complexity of protein corona formation, and the challenges of scalable, GMP-compliant synthesis. Finally, we propose a future roadmap integrating AI-driven material discovery and green chemistry to develop next-generation magnetotheranostic systems, positioning ferrite nanoplatforms as central components in the future of precision medicine.
SN  - 0935-9648
SN  - 1521-4095
ER  -