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Peer-reviewedCC BYBioactive Materials

Recent advances in functionalized electrospun nanofibers for biomedical and therapeutic applications: A comprehensive review

  • Kalim Deshmukh1
  • Mayank Pandey2
  • Hichem Moulahoum3
  • Faezeh Ghorbanizamani3
  • Tomáš Kovářík4
  • Agata Przekora-Kuśmierz5
  • Hemalata Jena6
  • Miral Vora7
  • Gautam Patel8
  • Priyabrat Pradhan9
9 affiliations
  1. 1New Technologies Research Centre, University of West Bohemia in Pilsen, 30100, Pilsen, Czech Republic; Corresponding author.
  2. 2Department of Physical Sciences, Kristu Jayanti (Deemed to be University), Bangalore, 560077, Karnataka, India; Corresponding author.
  3. 3Department of Biochemistry, Faculty of Science, Ege University, Izmir, 35100, Türkiye
  4. 4New Technologies Research Centre, University of West Bohemia in Pilsen, 30100, Pilsen, Czech Republic; Department of Material Science and Metallurgy, Faculty of Mechanical Engineering, University of West Bohemia in Pilsen, 30100, Pilsen, Czech Republic
  5. 5Institute of Pharmaceutical Sciences, Faculty of Medicine, KUL-The John Paul II Catholic University of Lublin, 20708, Poland
  6. 6School of Mechanical Engineering, Kalinga Institute of Industrial Technology (KIIT) Deemed to be University, Patia, Bhubaneswar, Odisha, 751024, India
  7. 7Department of Chemistry, Krishna School of Science, Drs. Kiran and Pallavi Patel Global University (KPGU), Varnama, Vadodara, Gujarat, 391243, India
  8. 8Department of Chemical Sciences, Parul Institute of Applied Sciences, Faculty of Applied Sciences, Parul University, Waghodia, Vadodara, Gujarat, 391760, India
  9. 9Department of Mechanical Engineering, Synergy Institute of Engineering and Technology, Dhenkanal, Odisha, 759001, India
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Abstract

Electrospun nanofibers (ESNFs) have become a major focus of modern research given their adaptable architecture, extensive interface, and distinctive physicochemical characteristics, making them appropriate for varied applications such as catalysis and environmental cleanup, drug delivery (DD), tissue engineering (TE), sensing, actuation, and various energy-related technologies. As a result, electrospinning (ES) has emerged as a versatile manufacturing technique, driving intensive efforts to engineer nanofibrous structures specifically for biomedical purposes. Functionalization of ESNFs can be achieved by embedding functional agents or altering surface chemistry to introduce specific functionalities. This review discusses the fabrication methods, optimization techniques, and broad biomedical applications of modified ESNFs, emphasizing their key properties, including biocompatibility, degradability, and safety profile. The article outlines various strategies for creating and modifying ESNFs, followed by a comprehensive analysis of their applications in tissue regeneration, DD, wound repair, antimicrobial therapy, cancer diagnostics and treatment, and biosensing. By critically evaluating recent advances, highlighting future directions, and addressing ongoing challenges about ES, this review underscores the transformative potential of functionalized ESNFs as efficient and adaptable biomaterials for biomedical technologies.

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Cite

BibTeXRIS
BibTeX
@article{deshmukh2026recent,
  title = {{Recent advances in functionalized electrospun nanofibers for biomedical and therapeutic applications: A comprehensive review}},
  author = {Kalim Deshmukh and Mayank Pandey and Hichem Moulahoum and Faezeh Ghorbanizamani and Tomáš Kovářík and Agata Przekora-Kuśmierz and Hemalata Jena and Miral Vora and Gautam Patel and Priyabrat Pradhan},
  journal = {Bioactive Materials},
  year = {2026},
  month = oct,
  doi = {10.1016/j.bioactmat.2026.10.009},
  url = {https://doi.org/10.1016/j.bioactmat.2026.10.009},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Recent advances in functionalized electrospun nanofibers for biomedical and therapeutic applications: A comprehensive review
AU  - Kalim Deshmukh
AU  - Mayank Pandey
AU  - Hichem Moulahoum
AU  - Faezeh Ghorbanizamani
AU  - Tomáš Kovářík
AU  - Agata Przekora-Kuśmierz
AU  - Hemalata Jena
AU  - Miral Vora
AU  - Gautam Patel
AU  - Priyabrat Pradhan
PY  - 2026
DA  - 2026/10/22
JO  - Bioactive Materials
DO  - 10.1016/j.bioactmat.2026.10.009
UR  - https://doi.org/10.1016/j.bioactmat.2026.10.009
AB  - Electrospun nanofibers (ESNFs) have become a major focus of modern research given their adaptable architecture, extensive interface, and distinctive physicochemical characteristics, making them appropriate for varied applications such as catalysis and environmental cleanup, drug delivery (DD), tissue engineering (TE), sensing, actuation, and various energy-related technologies. As a result, electrospinning (ES) has emerged as a versatile manufacturing technique, driving intensive efforts to engineer nanofibrous structures specifically for biomedical purposes. Functionalization of ESNFs can be achieved by embedding functional agents or altering surface chemistry to introduce specific functionalities. This review discusses the fabrication methods, optimization techniques, and broad biomedical applications of modified ESNFs, emphasizing their key properties, including biocompatibility, degradability, and safety profile. The article outlines various strategies for creating and modifying ESNFs, followed by a comprehensive analysis of their applications in tissue regeneration, DD, wound repair, antimicrobial therapy, cancer diagnostics and treatment, and biosensing. By critically evaluating recent advances, highlighting future directions, and addressing ongoing challenges about ES, this review underscores the transformative potential of functionalized ESNFs as efficient and adaptable biomaterials for biomedical technologies.
SN  - 2452-199X
ER  -